Results 211 to 220 of about 3,167 (267)

In vitro α-amylase and α-glucosidase inhibition study of dihydropyrimidinones synthesized via one-pot Biginelli reaction in the presence of a green catalyst.

Bioorganic chemistry (Print)
A green catalyst WELPSA-catalyzed three-component condensation (Biginelli) process involving an aldehyde, barbituric/thiobarbituric/1,3-dimethylbarbituric acid, and urea/thiourea/guanidine hydrochloride in a single pot in presence of a green solvent for ...
Vinuta Kamat, D. Barretto, B. Poojary, Amit Kumar, Veerabhadragouda B. Patil, S. Hamzad   +5 more
semanticscholar   +1 more source

Medicinal perspective of a promising scaffold – dihydropyrimidinones: A review

Journal of Heterocyclic Chemistry
Dihydropyrimidinones (DHMPs) are the most important pharmacophore in Medicinal Chemistry. The synthetic approach for deriving DHMPs involves the Biginelli reaction or a combination of it with other multi‐component reactions (MCRs).
Bhavesh H. Sarvaiya, Palak I. Vaja, Niraj A. Paghdar, Satish M. Ghelani   +3 more
semanticscholar   +1 more source

Synthesis of Dihydropyrimidinones and Dihydropyrimidin(thio)ones in Ionic Liquid: A Systematic Review on Biginelli Reaction

ChemistrySelect
The Biginelli reaction, first introduced in 1893, is a key one‐pot condensation reaction in organic chemistry that facilitates the synthesis of dihydropyrimidinones (DHPMs) and dihydropyrimidin(thio)ones (DHPMTs).
Smitkumar D. Vankar, Hardi M. Makwana, Mayank G. Sharma   +2 more
semanticscholar   +1 more source

Synthesis of dihydropyrimidinones via multicomponent reaction route over acid functionalized Metal-Organic framework catalysts.

Journal of Colloid and Interface Science, 2021
Multi component reactions over heterogeneous solid acid catalysts are extremely important owing to easy separation, amenable recycling, and prospective scaling up of the process.
B. Krishna, Soumitra Payra, S. Roy
semanticscholar   +1 more source

Synthesis and anticancer activity of new dihydropyrimidinone derivatives

European Journal of Medicinal Chemistry, 2018
A series of dihydropyrimidinone derivatives bearing various N-heterocyclic moieties was designed and synthesized. Twelve new compounds were screened for their cytotoxic activity using 60 cancer cell lines according to NCI (USA) protocol. Compound 19 showed a significant activity against NCI-H460, SK-MEL-5, and HL-60 (TB) cell lines with growth ...
Amany S. Mostafa, Khalid B. Selim
openaire   +2 more sources

A Review On The Synthetic Methodologies And Therapeutic Significance Of 3,4-Dihydropyrimidinones

Journal of Neonatal Surgery
3,4-Dihydropyrimidinones are the most important heterocyclic compounds that are significant in the synthesis of nucleic acids. Dihydropyrimidinones have been produced by multi-component processes like the Biginelli reaction and the ...
Saritha Boora, S. Lakshmi
semanticscholar   +1 more source

Asymmetric alkylations of n-acyl dihydropyrimidinones

Tetrahedron: Asymmetry, 1991
Abstract Enantiomerically pure dihydropyrimidin-4-one 1 has been employed as a chiral auxiliary for enantioselective alkylation reactions. Acylation of 1 , followed by enolate formation, alkylation and acyl cleavage, affords α-alkylated carboxylic acids in high chemical yield and enatiomeric purity.
George R. Negrete, Joseph P. Konopelski
openaire   +1 more source

DIHYDROPYRIMIDINONES: AN EXPLORATION OF THEIR SYNTHETIC STRATEGIES, SARs AND DIVERSE THERAPEUTIC POTENTIALS

Indian drugs
Dihydropyrimidinones (DHPMs) represent a vital class of heterocyclic compounds with diverse therapeutic applications. This review explores recent advances in synthetic strategies, including classical Biginelli reactions and modern green methodologies for
D. Nikam, Shraddha Vetale
semanticscholar   +1 more source

Efficient Synthesis of Dihydropyrimidinones Using Advanced Ni (II)‐Doped Zn‐BDC Microcrystals: A Breakthrough in Catalytic Performance, Reusability, and Structural Integrity

Applied organometallic chemistry
Nickel (II) ions (Ni (II)) doped into the zinc‐based metal–organic framework Zn‐BDC have shown exceptional catalytic activity as heterogeneous catalysts for the three‐component Biginelli condensation reaction, delivering yields ranging from 62% to 96 ...
D. Aziz, Othman Othman
semanticscholar   +1 more source

Novel Dihydropyrimidinones Synthesized through Modified Biginelli Reaction as Eg5 Kinesin Inhibitors with Potential Anti-cancer Effects: In vitro and In vivo Studies.

Anti-Cancer Agents in Medicinal Chemistry
BACKGROUND Monastrol is a known kinesin Eg5 inhibitor. It is a dihydropyrimidine with 4-(mhydroxyphenyl) substituent. In contrast to taxols and vinca alkaloids, which, through targeting microtubules, affect both normal and cancer cells, kinesin ...
M. Nejabat, Samin Ghorbani Moghadam, Vahid Eskandarpour, Masoud Nejabat, Mahda S. Nasrollahzadeh, F. Hadizadeh   +5 more
semanticscholar   +1 more source