Results 21 to 30 of about 19,826 (185)

mGluR5 Mediates Dihydrotestosterone-Induced Nucleus Accumbens Structural Plasticity, but Not Conditioned Reward

Frontiers in Neuroscience, 2018
Gonadal hormones play a vital role in driving motivated behavior. They not only modulate responses to naturally rewarding stimuli, but also influence responses to drugs of abuse. A commonality between gonadal hormones and drugs of abuse is that they both
Kellie S. Gross, Kellie S. Gross, Kelsey M. Moore, Kelsey M. Moore, Robert L. Meisel, Robert L. Meisel, Paul G. Mermelstein, Paul G. Mermelstein   +7 more
doaj   +1 more source

AMH Regulation by Steroids in the Mammalian Testis: Underlying Mechanisms and Clinical Implications

Frontiers in Endocrinology, 2022
Anti-Müllerian hormone (AMH) is a distinctive biomarker of the immature Sertoli cell. AMH expression, triggered by specific transcription factors upon fetal Sertoli cells differentiation independently of gonadotropins or sex steroids, drives Müllerian ...
Nadia Y. Edelsztein, Clara Valeri, María M. Lovaisa, Helena F. Schteingart, Rodolfo A. Rey, Rodolfo A. Rey   +5 more
doaj   +1 more source

Sex hormones in female residents of Yamal-Nenets autonomous district depending on the fertility status

Сибирский научный медицинский журнал, 2020
Severe climatic conditions adversely affect the human reproductive function; there is evidence of earlier aging of the endocrine system in residents of the northern territories.
A. E. Elfimova
doaj   +1 more source

Preoperative Hormonal Stimulation In Hypospadias: A Systematic Review

The Annals of African Surgery, 2023
Background: Preoperative hormonal stimulation with testosterone or estrogen is an emerging treatment modality for hypospadias, which can potentially improve surgical outcomes and reduce the risk of complications.
Indrayudha Pramono, Safendra Siregar, Jupiter Sibarani   +2 more
doaj   +1 more source

Sex Steroids and Osteoarthritis: A Mendelian Randomization Study

Frontiers in Endocrinology, 2021
ObjectiveSex steroids are thought to contribute to the pathogenesis of osteoarthritis (OA). This study investigated the causal role of sex steroids in site- and sex-specific OA and risk of joint replacement surgery using the Mendelian randomization (MR ...
Yi-Shang Yan, Zihao Qu, Zihao Qu, Dan-Qing Yu, Dan-Qing Yu, Wei Wang, Wei Wang, Shigui Yan, Shigui Yan, He-Feng Huang   +9 more
doaj   +1 more source

A Convenient Plant-Based Detection System to Monitor Androgenic Compound in the Environment

Plants, 2019
Environmental androgen analogues act as endocrine disruptors, which inhibit the normal function of androgen in animals. In the present work, through the expression of a chimeric gene specified for the production of the anthocyanin in response to androgen
Dong-Gwan Kim, Ramin Bahmani, Jae-Heung Ko, Seongbin Hwang   +3 more
doaj   +1 more source

Transcriptome Analysis Reveals an Inhibitory Effect of Dihydrotestosterone-Treated 2D- and 3D-Cultured Dermal Papilla Cells on Hair Follicle Growth

Frontiers in Cell and Developmental Biology, 2021
Dermal papillae are a target of androgen action in patients with androgenic alopecia, where androgen acts on the epidermis of hair follicles in a paracrine manner.
Yufan Zhang, Junfei Huang, Danlan Fu, Zhen Liu, Hailin Wang, Jin Wang, Qian Qu, Kaitao Li, Zhexiang Fan, Zhiqi Hu, Yong Miao   +10 more
doaj   +1 more source

Steroid Recognition in Adhesion GPCRs: A Structural and Pharmacological Perspective. [PDF]

Pharmacol Res Perspect
ABSTRACT Emerging evidence suggests steroids may act as generalizable ligands for adhesion GPCRs, a receptor class with considerable pharmacological potential. While most studies have focused on the ADGR‘G' subfamily, recent cryo‐EM structures of the androgens 5α‐dihydrotestosterone (5α‐DHT) and methenolone bound to ADGRD1 revealed a putative steroid ...
Fleming B, Guseinov AA, Tikhonova IG, Milligan G, Perry-Hauser NA.   +4 more
europepmc   +2 more sources

An Updated Etiology of Hair Loss and the New Cosmeceutical Paradigm in Therapy: Clearing ‘the Big Eight Strikes’

Cosmetics, 2023
In this current review, research spanning the last decade (such as transcriptomic studies, phenotypic observations, and confirmed comorbidities) has been synthesized into an updated etiology of hair loss and applied to the new cosmeceutical paradigm of ...
Nicholas Sadgrove, Sanjay Batra, David Barreto, Jeffrey Rapaport   +3 more
doaj   +1 more source

Macrophage Membrane‐Cloaked, ROS‐Triggered Quercetin Nanocarriers Target Ovarian Lesions to Treat Polycystic Ovary Syndrome

Advanced Healthcare Materials, EarlyView.
The synthesis process of MM@PCD@QNPs and its potential mechanism for treating PCOS. (A) Assembly steps of MM@PCD@QNPs. (B) Synthesis and decomposition of MM@PCD@QNPs. (C) Potential therapeutic mechanisms of MM@PCD@QNPs for PCOS. PCD, PABP conjugated with DEX polymer; QUR, quercetin; CDI, N, N′‐carbonyldiimidazole; DEX, dextran; PABP, 4‐(hydroxymethyl ...
Wenzhu Li, Yu Guan, Nan Song, Feng Zhang, Zhimin Deng, Tailang Yin, Yanbing Yang, João Conde, Wenyi Jin, Zhinang Yin   +9 more
wiley   +1 more source