Results 71 to 80 of about 19,826 (185)

Mapping molluscan endocrinology: a systematic and critical appraisal

Biological Reviews, Volume 101, Issue 2, Page 970-1002, April 2026.
ABSTRACT Historically, a vertebrate‐centric paradigm has framed our interpretation of molluscan endocrinology, with considerable research focusing on vertebrate‐type steroid hormones (e.g. oestrogens, testosterone). However, contradictory evidence on the occurrence of vertebrate‐type steroid hormones in molluscan tissues, and a lack of the specific ...
Konstantinos Panagiotidis, Thomas H. Miller, Olwenn V. Martin, Alice Baynes   +3 more
wiley   +1 more source

Functional Segregation of Pancreatic Microcirculation Reveals Sex‐Dependent Microhemodynamic Signatures

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Pancreatic exocrine microcirculation exhibits sexual dimorphism arising from steroid–genetic interactions. Laser Doppler flowmetry combined with wavelet analysis identifies a male passive coupling phenotype aligned with systemic pressure and a female active vasomotion phenotype driven by ERβ‐mediated, NO‐dependent oscillations.
Yuan Li, Yingyu Wang, Bing Wang, Qin Ouyang, Weiqi Liu, Xiang Xu, Xu Zhang, Mingming Liu, Ruijuan Xiu   +8 more
wiley   +1 more source

ABILITY TO RESTORE REPRODUCTIVE SYSTEM IN PATHINTS WITH COMBINED FORM OF HYPERANDROGENISM

Акушерство, гинекология и репродукция, 2016
Combined form of hyperandrogenism is one of the leading pathogenic causes of menstrual and reproductive disfunctions. Anovulation state causes an increase in the level of the main androgens, and the luteal phase deficiency is a consequence of the ...
R. A. Saidova, O. A. Monastyrnaya, A. G. Davudova   +2 more
doaj   +1 more source

Pregnane X Receptor Regulates Human Endocrine System by Inducing Sex Hormone–Binding Globulin Expression

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 4, April 2026.
ABSTRACT Sex hormone–binding globulin (SHBG) is a sex hormone carrier. We aimed to characterize the role of pregnane X receptor (PXR), a major regulator of drug metabolism, in SHBG regulation. Serum SHBG was measured in four clinical trials (n = 61) and expression in in vitro experiments in human 3D hepatocyte spheroids and HepG2 cells.
Maria H. Ahonen, Anja Konzack, Tomas Smutny, Petr Pavek, Jukka Hakkola, Janne Hukkanen   +5 more
wiley   +1 more source

Combined therapy with dutasteride and tadalafil vs dutasteride or tadalafil monotherapy in benign prostatic hyperplasia: a randomised phase III trial

BJU International, Volume 137, Issue 4, Page 698-707, April 2026.
Objectives To evaluate the efficacy and safety of a fixed‐dose combination (FDC) of dutasteride and tadalafil vs monotherapy in patients with benign prostatic hyperplasia (BPH). Patients and Methods This phase III trial enrolled 667 patients. After screening and washout, eligible patients were stratified by the baseline International Prostate Symptom ...
Seung Wook Lee, Seung Hwan Lee, Jae Heon Kim, Joon Hwa Noh, Jun Ho Lee, U‐Syn Ha, Cheol Young Oh, Taek Won Kang, Gyeongseop Lee, Sangchul Lee, Deok Hyun Han, Jun Hyun Han, Sang Hoon Song, Hyun Jun Park, Byung Ha Chung, Gyeong Eun Min, In Gab Jeong, Kyung Hyun Moon, Won Tae Kim, Ji Youl Lee, Choung‐Soo Kim   +20 more
wiley   +1 more source

TO DETERMINE CUT OFF OF FERTILITY PROFILE OF PATIENTS WITH ANDROGEN INSENSITIVITY SYNDROME (AIS) AT DIFFERENT AGES IN PAKISTANI POPULATION

Pakistan Armed Forces Medical Journal, 2020
Objective: Current study was aimed to determine cut off value of fertility profile in patients with Androgen Insensitivity Syndrome (AIS) presented at different ages tertiary care hospital of Rawalpindi, Pakistan. Study Design: Cross sectional study.
Waqas Hanif, Naveed Asif, Muhammad Younas, Zujaja Hina Haroon, Qurat Ul Ain, Noreen .   +5 more
doaj  

Endogenous oestrogens as neuroprotective modulators in the human retina: Evidence from transcriptomic profiling and aromatase inhibition

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Single‐cell transcriptomics reveals that the human retina expresses a broad repertoire of steroid hormone biosynthesis and estrogen signalling genes. Functional validation in retinal explants shows that local estrogen synthesis is neuroprotective, preventing photoreceptor death and limiting microglial activation. Abstract Steroid hormones, particularly
Antolin Canto, Javier Valero‐Ochando, Rosa López‐Pedrajas, Teresa Olivar, Vicente Hernández‐Rabaza, Inmaculada Almansa, María Miranda   +6 more
wiley   +1 more source

Arachis hypogaea L. Root Extract Mitigates Testosterone Propionate‐Induced Benign Prostatic Hyperplasia in ICR Mice by Suppressing Inflammation, Androgen Receptors, and Dihydrotestosterone

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
In summary this study evaluated the protective effects of Arachis hypogaea L. root extract (AHRE) against testosterone propionate (TP)‐induced benign prostatic hyperplasia (BPH) in ICR mice. AHRE was prepared and administered in varying doses (100, 200, 300 mg/kg BW) alongside TP, with finasteride as a positive control.
Samee‐Ullah, Faryal Shaukat, Muhammad Umair Ijaz, Muhammad Bilal, Anees Ahmed Khalil, Tausif Ahmad, Yemin Guo, Xia Sun, Yuanda Song, Mohammed Mansour Quradha   +9 more
wiley   +1 more source

Effects of 17α‐Ethinylestradiol on Development and Gonadal Differentiation in the Estuarine Mummichog, Fundulus heteroclitus

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 2, Page 148-161, March 2026.
ABSTRACT In fish, sex determination and gonadal development are controlled by various genetic and environmental factors. In this study, experiments were conducted on the estuarine mummichog (Fundulus heteroclitus) to investigate gonadal differentiation following exposure to the synthetic estrogen, 17α‐ethinylestradiol (EE2).
Ibrahim Chehade, Carly Sing‐Judge, Emily Corrigan, Andrea Lister, Glen Van Der Kraak, Deborah MacLatchy   +5 more
wiley   +1 more source

Anti-Hair Loss Effects of the DP₂ Antagonist in Human Follicle Dermal Papilla Cells

Cosmetics
Prostaglandin D2 (PGD2) levels are high in the balding areas of human scalps, and PGD2 has been found to inhibit hair growth. It is known that the inhibition of the PGD2 receptor can promote hair growth by preventing hair follicles from entering the ...
Hye Won Lim, Hyunwoo Joo, Chae Young Jeon, Yurim Lee, Mujun Kim, Jung Un Shin, Jinsick Kim, SoonRe Kim, Sanghwa Lee, Dong Chul Lim, Hee Dong Park, Byung Cheol Park, Dong Wook Shin   +12 more
doaj   +1 more source