Results 81 to 90 of about 19,826 (185)

Phytochemical Profiling of the Halophyte Artemisia fukudo Makino and Its In Vitro Effects on Androgen‐Related Pathways Associated With Benign Prostatic Hyperplasia and Alopecia

ChemistryOpen, Volume 15, Issue 3, March 2026.
This study investigated the phytochemical constituents of the halophyte Artemisia fukudo, leading to the isolation and identification of eight compounds characterized by HPLC–DAD and ESI–MS. Importantly, we demonstrate for the first time that jaceidin inhibits 5α‐reductase type 2 and downregulates BPH‐associated proteins (AR, PSA, and PCNA) in prostate
Yun Na Kim, Jae Sun Lee, Min Gyu Park, Yu Jung Kim, Seon Min Lee, Kwang Hyun Hwang, Min Hye Yang, Bong‐Oh Kwon, Jung‐Rae Rho, Eun Ju Jeong   +9 more
wiley   +1 more source

Effect of a Combination of Dutasteride and Parenteral Testosterone Undecanoate on Testosterone Deficiency Symptoms and Prostate in Patients with Testosterone Efficiency and Benign Prostatic Hyperplasia

Journal of Men's Health, 2020
Background and objective The effect of a combination of testosterone and 5-Alpha reductase inhibitors (5-ARIs) on serum tes-tosterone levels, TD symptoms, and the prostate are not sufficiently established.
Min Gu Park, Seok Cho, Jae Yoon Kim, Jeong Kyun Yeo   +3 more
doaj  

A Hybrid Nanosystem for Prostate Cancer Therapy: Codelivery of Enzalutamide and Curcumin via Selenium‐Embedded Mesoporous Silica and Chitosan Nanoparticles

ChemistryOpen, Volume 15, Issue 3, March 2026.
Herein, solvent extraction was selected for cetyltrimethylammonium bromide removal and the development of optimized Se‐embedded mesoporous silica nanoparticles, which were loaded with enzalutamide. Additionally, to improve the anticancer activity of Se@MSNPs‐Enz and curcumin bioavailability, curcumin‐loaded chitosan nanoparticles were prepared. This pH‐
Zahra Tavakoli, Khosro Khajeh, Bijan Ranjbar   +2 more
wiley   +1 more source

The Oxytocin Receptor in Spermatozoa May Originate From Both Spermatogenesis and Epididymal Maturation, and Regulates Capacitation

Andrology, Volume 14, Issue 3, Page 747-765, March 2026.
Abstract Background The oxytocin receptor (OR) is a G‐protein‐coupled receptor recently identified in human spermatozoa, whose origin and role in sperm physiology remain unknown. Objectives In this study, using the pig as a model, we examine the presence of the OR in ejaculated spermatozoa through immunofluorescence and immunoblotting, and investigate ...
Jesús Martínez‐Hernández, Ferran Garriga, Adeel Ahmad, Lorena Padilla, Carolina Maside, Sergi Bonet, Isabel Barranco, Jordi Roca, Luis Miguel Pastor, Marc Yeste   +9 more
wiley   +1 more source

INSL3 Expression in Leydig Cells is a Biomarker for Immunocastration in Boars: Transcriptional Evidence

Andrology, Volume 14, Issue 3, Page 782-795, March 2026.
ABSTRACT Background Study aimed to obtain insights into physiological responses to immunocastration in pubertal boars by evaluating effects of alternative vaccination protocols and identifying a reliable immunocastration biomarker. Objectives It was hypothesized that the timing of gonadotropin‐releasing hormone (GnRH) suppression by immunocastration ...
Nina Batorek Lukač, Martin Škrlep, Klavdija Poklukar, Petra Ferjan, Volker Stefanski, Gregor Fazarinc, Milka Vrecl   +6 more
wiley   +1 more source

Sex Matters: Hormonal and Chromosomal Determinants of Autoimmunity and Anti‐Cancer Immunity Across the Lifespan

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Sex plays a key role in shaping both anti‐cancer immunity and autoimmunity. Biological factors underlying sexual dimorphism have now been identified in multiple aspects of anti‐cancer immunity and autoimmunity. These factors include sex differences in hormone levels, chromosome complement, and expression of the long non‐coding RNA XIST.
Christian G. Bustillos, Esther M. Peluso, Sophia L. Cha, Melissa G. Lechner, Maureen A. Su   +4 more
wiley   +1 more source

Sex Differences in Lung Immunity

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Biological sex has a significant impact on how the immune system develops and responds to foreign and self‐antigens. Sex differences exist in innate and adaptive immune cells, both at homeostasis and in the context of infection and inflammatory diseases such as asthma, cancer, and autoimmune disorders.
Franz Puttur, Clare M. Lloyd
wiley   +1 more source

The X Factor in Immunity: Sex Differences Shaped by the X Chromosome

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT There are sex differences with immune responses where females exhibit stronger immune responses compared to males. Both sex hormones and sex chromosome differences between males and females contribute to the observed sex differences with innate and adaptive immune cell composition and function.
Katherine B. Radovanovic, Megan Wynalda, Montserrat C. Anguera   +2 more
wiley   +1 more source

Finasteride withdrawal induces anxiety‐like behavior and novelty avoidance in adult male rats

Journal of Neuroendocrinology, Volume 38, Issue 3, March 2026.
Abstract Finasteride, an inhibitor of the enzyme 5alpha‐reductase, prescribed for benign prostatic hyperplasia and androgenetic alopecia, induces a wide variety of side effects during treatment and upon withdrawal, like sexual dysfunction and cognitive and psychological disorders, inducing the so‐called post‐finasteride syndrome (PFS).
Lucia Cioffi, Silvia Diviccaro, Gabriela Chrostek, Francesco Paolo Ulloa Severino, Silvia Giatti, Diego Scheggia, Roberto Cosimo Melcangi   +6 more
wiley   +1 more source

Profile of gonadotropin secretion in male and female rats determined in the tail‐tip blood by ultrasensitive ELISA

Journal of Neuroendocrinology, Volume 38, Issue 3, March 2026.
Abstract There is a need for accurate and less invasive methods of hormonal measurements. Here, we longitudinally determined luteinizing hormone (LH) and follicle‐stimulating hormone (FSH) secretion measured in the tail‐tip blood of male and female rats by ultrasensitive enzyme‐linked immunosorbent assay (ELISA).
Roberta Araujo‐Lopes, Andre F. Gomes, Matheus Viana, Mariana De S. Santos, Ana C. Campideli‐Santana, Soraia Macari, Adelina M. Reis, Raphael E. Szawka   +7 more
wiley   +1 more source