Results 91 to 100 of about 20,405 (323)

Mechanistic studies of anti-hyperpigmentary compounds: elucidating their inhibitory and regulatory actions. [PDF]

, 2014
Searching for depigmenting agents from natural sources has become a new direction in the cosmetic industry as natural products are generally perceived as relatively safer.
Cheng, CH, Lam, RY, Lin, ZX, Sviderskaya, EV   +3 more
core   +2 more sources

AI Guided Protein Design for Next‐Generation Autogenic Engineered Living Materials

Advanced Intelligent Systems, EarlyView.
Autogenic engineered living materials (ELMs) integrate biology and materials science to create self‐regenerating and self‐healing materials. This perspective highlights emerging strategies in protein engineering and AI‐guided de novo design to expand the capabilities of autogenic ELMs.
Hoda M. Hammad, Anna M. Duraj‐Thatte
wiley   +1 more source

A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function. [PDF]

, 2019
The intra-renal dopamine (DA) system is highly expressed in the proximal tubule and contributes to Na+ and blood pressure homeostasis, as well as to the development of nephropathy.
Baker, Dewleen G, Biswas, Nilima, González-Sarmiento, Rogelio, Hightower, C Makena, Ichinose, Hiroshi, Kurosaki, Hiroki, León-Jiménez, David, Lipkowitz, Michael S, Mahata, Manjula, Miramontes-Gonzalez, Jose Pablo, Nievergelt, Caroline M, O'Connor, Daniel T, Schork, Andrew J, Vaingankar, Sucheta, Zhang, Kuixing, Ziegler, Michael G   +15 more
core   +2 more sources

Understanding Neurodegenerative Diseases From the −Omics Perspective: Lessons Learnt

Annals of Neurology, EarlyView.
As the population ages, certain neurodegenerative diseases (NDs) are becoming a major health issue. For this reason, this review will focus on the most common ND with onset after 65 years old; Alzheimer's disease, Parkinson's disease, Lewy body dementia, and frontotemporal dementia.
Laura Ibanez, Cyril Pottier, Aleksandra Beric, Daniel Western, Muhammad Ali, Carlos Cruchaga   +5 more
wiley   +1 more source

Zur Synthese von 6[18F]Fluor-L-DOPA durch nukleophile 18F-Fluorierung Carbonyl-aktivierter aromatischer Aminosäurederivate [PDF]

, 2001
6-[$^{18}$F]Fluoro-L-3,4-dihydroxyphenylalanine (6-[$^{18}$F]fluoro-L-DOPA), an analogue of L-DOPA, is an established radiotracer for diagnostic PET-studies of the integrity and function of the nigrostriatal dopaminergic system. The use of this important
Tierling, Thomas
core  

Identification and characterization of the PhhR regulon in Pseudomonas putida [PDF]

, 2010
Pseudomonas putida is a soil microorganism that utilizes aromatic amino acids present in root exudates as a nitrogen source. We have previously shown that the PhhR transcriptional regulator induces phhAB genes encoding a phenylalanine hydroxylase.
Duque, Estrella, Fernandez Escamilla, Ana, Herrera, Carmen, Ramos, Juan Luis, Rodríguez Herva, Jose Juan   +4 more
core   +2 more sources

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Synthesis of Novel Chiral L-Phenylalanine Grafted PEDOT Derivatives with Electrochemical Chiral Sensor for 3,4-Dihydroxyphenylalanine Discrimination

International Journal of Electrochemical Science, 2015
Two amino-functionalized chiral poly(3,4-ethylenedioxythiophene) (PEDOT) derivatives, poly(N-(tert-butoxycarbonyl)-L-phenylalayl (3,4-ethylenedioxythiophene-2'-yl)methylamide) (PEDOT-Boc-Phe) and poly(L-phenylalayl (3,4-ethylenedioxythiophene-2'-yl ...
Dufen Hu, Baoyang Lu, Kaixin Zhang, Xiaoxia Sun, Jingkun Xu, Xuemin Duan, Liqi Dong, Hui Sun, Xiaofei Zhu, Shijie Zhen   +9 more
doaj   +1 more source

Insights on cytotoxic cells of the colonial ascidian Botryllus schlosseri [PDF]

, 2015
Morula cells (MCs) represent the most abundant circulating hemocyte of the compound ascidian Botryllus schlosseri. They are cytotoxic cells involved in the rejection reaction between contacting, genetically incompatible colonies.
Ballarin, Loriano, Cima, Francesca, Franchi, Nicola   +2 more
core