Results 71 to 80 of about 11,997 (297)

Translational incorporation of L-3,4-dihydroxyphenylalanine into proteins [PDF]

, 2005
An Escherichia coli cell-free transcription/translation system was used to explore the high-level incorporation Of L-3,4-dihydroxyphenylalanine (DOPA) into proteins by replacing tyrosine with DOPA in the reaction mixtures.
Watt, S.J., Headlam, MJ, Roger T. Dean, Beck, Jennifer L., Kiyoshi Ozawa, Gottfried Otting, Headlam, Madeleine, Dean, RT, Beck, JL, Headlam, M.J., Otting, Gottfried, Dixon, N.E., Ozawa, K., Watt, Stephen J., Dean, Roger T., Huber, T, Huber, Thomas, Beck, Jennifer, Headlam, Madeleine J., Ozawa, Kiyoshi, Dean, Roger, Watt, SJ, Dixon, Nicholas, Mouradov, Dmitri, Madeleine J. Headlam, Stephen J. Watt, Ozawa, K, Otting, G, Mouradov, D, Mouradov, D., Jennifer L. Beck, Dixon, Nicholas E., Rodgers, KJ, Huber, T., Rodgers, Kenneth J., Thomas Huber, Kenneth J. Rodgers, Nicholas E. Dixon, Otting, G., Watt, Stephen J, Dixon, NE, Rodgers, Kenneth, Beck, J.L., Dmitri Mouradov   +43 more
core   +1 more source

Enhanced effect of the hallucinogen DOI in L-DOPA receptor Gpr143-deficient mice

Journal of Pharmacological Sciences
Hallucinogens, such as lysergic acid diethylamide, act primarily through the 5-hydroxytryptamine 2A (5-HT2A) receptor, but their regulatory mechanisms remain unclear.
Daiki Masukawa, Rei Tajika, Yoshimi Ichimaru, Masaaki Kurihara, Tsutomu Suzuki, Yoshio Goshima   +5 more
doaj   +1 more source

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

3,4-Dihydroxyphenylalanine Peptides as Nonperturbative Quantum Dot Sensors of Aminopeptidase [PDF]

, 2016
Fluorescence-based assays for hydrolases that cleave within the substrate (endopeptidases) are common, while developing substrates for proteases that selectively cleave from peptide termini (exopeptidases) is more challenging, since the termini are ...
Valle Palomo (356637), Michael H. Stewart (1317345), Kimihiro Susumu (1511707), Igor L. Medintz (1317330), Philip E. Dawson (1275774), Sebastián A. Díaz (1512589)   +5 more
core   +1 more source

A Disulfide‐Sticker Strategy for Marine Adhesive Coatings: From Deciphering Self‐Assembly Mechanism to Functional Application in Hair Regeneration

Advanced Science, EarlyView.
A disulfide‐sticker strategy, coupled with Ca2+ coordination, drives the hierarchical self‐assembly of a recombinant scallop adhesive protein into fishnet‐like nanostructures, affording a coating with versatile wet adhesion and intrinsic antioxidant activity. This biocompatible coating markedly promotes hair regeneration by activating follicular niches,
Lulu Wang, Juan Yang, Xin Jiang, Zhanghui Zheng, Hongyu Wei, Na Li, Xiangqiang Chu, Weizhi Liu   +7 more
wiley   +1 more source

Polydopamine Nanoparticle‐Mediated Precise Near‐Infrared Optical Stimulation for Cognitive Enhancement

Advanced Science, EarlyView.
Polydopamine nanoparticles enable a precise, non‐genetic, and transcranial neuromodulation strategy via near‐infrared photothermal stimulation. By activating TRPV1 channels, this approach specifically enhances hippocampal gamma oscillations, thereby rescuing spatial memory deficits in models of perioperative neurocognitive disorder.
Yan‐Bo Zhou, Qiong Xue, Su‐Xuan Hou, Ke‐Yao Zhang, Wei‐Tong Pan, Ting‐Ting Zeng, Yu‐Ge Wang, Daqing Ma, Chenguang Zhao, Pan‐Miao Liu, Jian‐Jun Yang   +10 more
wiley   +1 more source

Nucleophilic Synthesis of 6-l-[¹⁸F]FDOPA. Is Copper-Mediated Radiofluorination the Answer?

Molecules, 2020
Positron emission tomography employing 6-l-[18F]fluoro-3,4-dihydroxyphenylalanine (6-l-[18F]FDOPA) is currently a highly relevant clinical tool for detection of gliomas, neuroendocrine tumors and evaluation of Parkinson’s disease progression.
Raisa N. Krasikova
doaj   +1 more source

RETRACTION: Differential Involvement of Ras‐GRF1 and Ras‐GRF2 in L‐DOPA‐Induced Dyskinesia

Annals of Clinical and Translational Neurology, EarlyView.
RETRACTION: S. Bido, N. Solari, M. Indrigo, A. D’Antoni, R. Brambilla, M. Morari, and S. Fasano, “Differential Involvement of Ras‐GRF1 and Ras‐GRF2 in L‐DOPA‐Induced Dyskinesia,” Annals of Clinical and Translational Neurology 2, no. 6 (2015): 662–678, https://doi.org/10.1002/acn3.202. The above article, published online on 24 April 2015 in Wiley Online
wiley   +1 more source

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

Advanced Science, EarlyView.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li, Haimin Chen, Gangqi Fang, Dongxiang Wei, Hongyun Wu, Chen Chen, Song Hong, Chengshu Wang   +7 more
wiley   +1 more source

Structural investigation of 3,4-dihydroxyphenylalanine-terminated propanethiol assembled on gold [PDF]

, 2003
3,4-Dihydroxyphenylalanine-terminated propanethiol (DOPA-PT), an amino acid DOPA linked to 3-mercaptopropionic acid through an amide bond, is adsorbed and self-assembled to polycrystalline gold surfaces.
Petoral, Rodrigo Jr,, Uvdal, Kajsa,
core   +1 more source