Results 91 to 100 of about 25,647 (343)

Evidence that tyrosine hydroxylase does not have enzymatic activity in neurons of the supraoptic nucleus

Frontiers in Endocrinology
IntroductionAlthough numerous neurons expressing tyrosine hydroxylase (TH), the first enzyme of catecholamine synthesis, were discovered in the supraoptic nucleus (SON) of hypothalamus in animals almost forty years ago, mainly under osmotic stress, the ...
Tatiana S. Pronina, Dmitry V. Troshev, Anna A. Kolacheva, Vsevolod V. Bogdanov, Michael V. Ugrumov   +4 more
doaj   +1 more source

Antiparkinsonian efficacy of guanosine in rodent models of movement disorder [PDF]

, 2017
Guanosine (GUO) is a guanine-based purine nucleoside with important trophic functions and promising neuroprotective properties. Although the neuroprotective effects of GUO have been corroborated in cellular models of Parkinson's disease (PD), its ...
Ciruela Alférez, Francisco, Fernández Dueñas, Víctor, López-Cano, Marc, Massari, Caio M., Núñez, Fabiana, Tasca, Carla I.   +5 more
core   +1 more source

Atomically precise metal cluster enzymes for pathological tissue regeneration

BMEMat, EarlyView.
Schematic illustration of atomically precise metal cluster enzymes (MCEs) for pathological tissue regeneration. Atomically precise MCEs can modulate biological processes, such as attenuation of inflammatory responses, eradication of bacterial pathogens, regulation of angiogenesis, and promotion of cell development.
Ziqiang Xiong, Zhifeng Shi, Mengqing Li, Jien Han, Haoyan Chen, Maofei Ran, Shaojian Zhong, Limin Ma, Chengyun Ning, Youzhun Fan, Zhenghua Tang, Peng Yu   +11 more
wiley   +1 more source

Determination of L-Dopa L-3, 4-dihydroxyphenylalanine Content of Some Faba Bean Vicia faba L. Genotypes

Journal of Agricultural Sciences, 2016
Faba bean, reflecting all properties of legume crops such as soil improvement and benefit of human health, also contains L-dopa which can be used to cure Parkinson’s disease, is a rare plant.
Nurdoğan Topal, Hatice Bozoğlu
doaj   +1 more source

A Stiff Injectable Biodegradable Elastomer [PDF]

, 2013
Injectable materials often have shortcomings in mechanical and drug-eluting properties that are attributable to their high water contents. A water-free, liquid four-armed PEG modified with dopamine end groups is described which changes from liquid to ...
Amsden, Amsden, Artzi, Barreto, Burke, Calvert, Chirila, Cho, Clarke, Clayton, Cory, Cory, Costa, Escobar-Chavez, Filpula, Gérentes, Halliwell, Hoare, Hoare, Hollister, Holten-Andersen, Homicz, Huang, Huang, Hudson, Ito, Jeon, Khetan, Kodera, Langer, Last, Lee, Lee, Levental, Lutolf, McDowell, Mizrahi, Paavola, Padera, Pierpont, Ramay, Ruel-Gariepy, Sanabria-DeLong, Seedher, Sever, Shultz, Wang, Younes, Yu, Zhang, Zhang, Zhang, Zhao   +52 more
core   +1 more source

A Mononuclear Scenario for the Copper‐Catalyzed Monooxygenation of Phenolic Substrates

Chemistry – A European Journal, EarlyView.
ABSTRACT Whereas a dinuclear pathway applies to the monooxygenation of phenols by the type 3 copper enzyme tyrosinase, a mononuclear pathway has been identified for the same reaction in corresponding small‐molecule systems. DFT calculations of five copper model complexes reveal that the latter mechanism is energetically feasible, identifying all ...
Alexander Koch, Antony Memboeuf, Felix Tuczek, Tobias A. Engesser   +3 more
wiley   +1 more source

Screen-Based Analysis of Magnetic Nanoparticle Libraries Formed Using Peptidic Iron Oxide Ligands [PDF]

, 2013
The identification of effective polypeptide ligands for magnetic iron oxide nanoparticles (IONPs) could considerably accelerate the high-throughput analysis of IONP-based reagents for imaging and cell labeling. We developed a procedure for screening IONP
Barch, Mariya, Bartelle, Benjamin B., Jasanoff, Alan Pradip, Okada, Satoshi   +3 more
core   +2 more sources

Endogenous 3,4-Dihydroxyphenylalanine and Dopaquinone Modifications on Protein Tyrosine

Molecular & Cellular Proteomics, 2010
Oxidative modifications of protein tyrosines have been implicated in multiple human diseases. Among these modifications, elevations in levels of 3,4-dihydroxyphenylalanine (DOPA), a major product of hydroxyl radical addition to tyrosine, has been ...
Xu Zhang, M. Monroe, Baowei Chen, M. H. Chin, Tyler H Heibeck, A. Schepmoes, Feng Yang, Brianne Petritis, D. Camp, J. Pounds, J. Jacobs, Desmond J. Smith, D. Bigelow, Richard D. Smith, W. Qian   +14 more
semanticscholar   +1 more source

In Vivo and In Vitro Evaluation of PTeCA (1H‐Pyrrole‐2,3,4,5‐Tetracarboxylic Acid) in Hair Matrix as a Marker for Oxidative Cosmetic Treatment

Drug Testing and Analysis, EarlyView.
A total of 3378 self‐reported treated and untreated hair samples were analyzed for PTCA and PTeCA by LC‐MS/MS. Moreover, their in vitro formation was assessed in 225 untreated hair by different cosmetic treatments with and without oxidative agents. Data suggest that PTeCA could be a reliable marker for oxidative cosmetic treatments in hair.
Sara Casati, Alessandro Ravelli, Roberta F. Bergamaschi, Agata Magliocco, Sofia Vanerio, Gabriella Roda, Paola Rota, Marica Orioli, Alessio Battistini   +8 more
wiley   +1 more source

Tetrahydrobiopterin Regulates L-tyrosine-induced Elevation of Cytosolic Calcium Concentration in Insulin-secreting Cells

Pteridines, 2006
We examined the role of endogenous tetrahydrobiopterin (BH4) on L-tyrosine-induced increase in cytosolic Ca: concentration ([Ca2+],) in the ß-cell line, HIT-T15.
Ishii Masakazu, Shimizu Shunichi, Watabe Tatsuya, Kiuchi Yuji   +3 more
doaj   +1 more source