Results 81 to 90 of about 25,647 (343)

Chronic 3,4-dihydroxyphenylalanine treatment induces dyskinesia in aphakia mice, a novel genetic model of Parkinson’s disease

Neurobiology of Disease, 2007
l-DOPA-induced dyskinesia (LID) is one of the main limitations of long term l-DOPA use in Parkinson’s disease (PD) patients. We show that chronic l-DOPA treatment induces novel dyskinetic behaviors in aphakia mouse with selective nigrostriatal deficit ...
Yunmin Ding, Jacqueline Restrepo, Lisa Won, Dong-Youn Hwang, Kwang-Soo Kim, Un Jung Kang   +5 more
doaj   +1 more source

En Route to a Chiral Melanin: The Dynamic “From-Imprinted-to-Template” Supramolecular Role of Porphyrin Hetero-Aggregates During the Oxidative Polymerization of L-DOPA

Frontiers in Chemistry, 2020
Chiral porphyrin hetero-aggregates, produced from meso-tetrakis(4-N-methylpyridyl) porphyrin H2T4 and copper(II) meso-tetrakis(4-sulfonatophenyl)porphyrin CuTPPS by an imprinting effect in the presence of L-3,4-dihydroxyphenylalanine (L-DOPA), are shown ...
Massimiliano Gaeta, Rosalba Randazzo, Valentina Villari, Norberto Micali, Alessandro Pezzella, Roberto Purrello, Marco d'Ischia, Alessandro D'Urso   +7 more
doaj   +1 more source

Mussel adhesive protein inspired coatings: a versatile method to fabricate silica films on various surfaces [PDF]

, 2012
A simple and versatile biomimetic strategy for the fabrication of silica films on a variety of substrates including gold, polystyrene and silicon wafers was developed using nanogram amounts per cm 2 of silicatein.
Akhilesh Rai, Bellomo, Belton, Belton, Belton, Belton, Bernecker, Bernmann, Betancor, Brott, Cai, Cai, Carole C. Perry, Carturan, Caruso, Cha, Cha, Coffman, Coradin, Croce, Dalsin, Giordano, Glawe, Grant, Hu, Hylton, Kambhampati, Kent, Kim, Kim, Kleijn, Knecht, Kroger, Kroger, Laugel, Lee, Lee, Lee, Luckarift, Lundgren, Macech, Menzel, Naik, Patwardhan, Patwardhan, Pogula, Rai, Rai, Ruach-Nir, Schmidt, Shimizu, Stein, Sun, Sun, Tahir, Tahir, Tahir, Thompson, Thompson, Tomczak, Underfriend, Waite, Waite, Waite, Waite, Xi, Xu, Yamamoto, Zhou   +68 more
core   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Pharmacology of Antiparkinsonian Agents [PDF]

, 1997
The following is a summary of a two hour class on the basic pharmacology of antiparkinsonian agents. It is presented to fourth-year pharmacy students in pharmacotherapeutics III, a course structured using team-taught modules.
Soltis, Robert P.
core   +1 more source

Patterns of Sedentary Time and Quality of Life in Women With Fibromyalgia: Cross-Sectional Study From the al-Ándalus Project [PDF]

, 2019
Background: Sedentary time (ST) has been associated with detrimental health outcomes in fibromyalgia. Previous evidence in the general population has shown that not only is the total amount of ST harmful but the pattern of accumulation of sedentary ...
Acosta Manzano, Pedro, Borges Cosic, Milkana María, Delgado Fernández, Manuel, Gavilán Carrera, Blanca, Segura Jiménez, Víctor, Álvarez Gallardo, Inmaculada Concepción   +5 more
core   +3 more sources

High-Frequency Stimulation of the Subthalamic Nucleus and l-3,4-Dihydroxyphenylalanine Inhibit In Vivo Serotonin Release in the Prefrontal Cortex and Hippocampus in a Rat Model of Parkinson's Disease

Journal of Neuroscience, 2010
High-frequency stimulation of the subthalamic nucleus (STN-HFS) and l-3,4-dihydroxyphenylalanine (l-DOPA) medication are the most used therapeutic approaches in Parkinson's disease (PD), but their beneficial motor effects are burdened by the emergence of
S. Navailles, A. Benazzouz, B. Bioulac, C. Gross, P. De Deurwaerdère   +4 more
semanticscholar   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Crystal nuclei templated nanostructured membranes prepared by solvent crystallization and polymer migration [PDF]

, 2016
Currently, production of porous polymeric membranes for filtration is predominated by the phase-separation process. However, this method has reached its technological limit, and there have been no significant breakthrough over the last decade.
Ji, J, Li, K, Wang, B
core   +1 more source

Systematic review and scoring‐based selection of pharmacokinetic models for precision dosing of vancomycin in neonates and children

British Journal of Clinical Pharmacology, EarlyView.
This systematic review identified 112 population pharmacokinetic models of vancomycin in neonates and children. To support rational model selection for model‐informed precision, we developed and applied expert‐driven, transparent criteria that integrate both methodological rigour and clinical relevance.
Zoë Vander Elst, Pieter‐Jan Spiessens, Dorian Vanneste, Nada Dia, Matthias Gijsen, Isabel Spriet, Karel Allegaert, Erwin Dreesen, Anne Smits   +8 more
wiley   +1 more source