Results 131 to 140 of about 24,273 (376)

Microbial colonization and function of biofilms developing on plastics and bioplastics in a pristine mountain stream ecosystem

open access: yesLimnology and Oceanography, EarlyView.
Abstract Streams naturally receive allochthonous particulate organic materials, but human activity may contribute additional plastic litter inputs, which can affect ecosystem functioning. Our objective was to assess the effect of plastic and bioplastic inputs on microbial biomass and function in a pristine mountain stream.
Mar Oliva‐Albert   +13 more
wiley   +1 more source

Chronic 3,4-dihydroxyphenylalanine treatment induces dyskinesia in aphakia mice, a novel genetic model of Parkinson’s disease

open access: yesNeurobiology of Disease, 2007
l-DOPA-induced dyskinesia (LID) is one of the main limitations of long term l-DOPA use in Parkinson’s disease (PD) patients. We show that chronic l-DOPA treatment induces novel dyskinetic behaviors in aphakia mouse with selective nigrostriatal deficit ...
Yunmin Ding   +5 more
doaj  

Prevalence and Clinical Characteristics of the LRRK2 p.L1795F Variant in Central Europeans with Early‐Onset and Familial Parkinson's Disease

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Leucine‐rich repeat kinase 2 (LRRK2) p.L1795F variant was proposed as a genetic risk factor for Parkinson's disease (PD). However, its prevalence, phenotype, and origin remain unknown. Objective The aim was to evaluate the frequency and phenotype of p.L1795F in early‐onset PD (EOPD) and familial PD compared to healthy controls (HC ...
Miriam Ostrozovicova   +35 more
wiley   +1 more source

Management of L-dopa overdose in the competitive inhibition state

open access: yesDrug, Healthcare and Patient Safety, 2014
Marty Hinz,1 Alvin Stein,2 Ted Cole3 1Clinical Research, NeuroResearch Clinics, Inc., Cape Coral, FL, USA; 2Stein Orthopedic Associates, Plantation, FL, USA; 3Cole Center for Healing, Cincinnati, OH, USA Abstract: The amino acid L-3,4 ...
Hinz M, Stein A, Cole T
doaj  

Multiple transitions to high l-DOPA 4,5-dioxygenase activity reveal molecular pathways to convergent betalain pigmentation in Caryophyllales. [PDF]

open access: yesNew Phytol
Summary Many specialized metabolic pathways have evolved convergently in plants, but distinguishing multiple origins from alternative evolutionary scenarios can be difficult. Here, we explore the evolution of l‐3,4‐dihydroxyphenylalanine (l‐DOPA) 4,5‐dioxygenase (DODA) enzymes to better resolve the convergent evolution of the betalain biosynthetic ...
Walker-Hale N   +2 more
europepmc   +2 more sources

Effects of L-3,4-dihydroxyphenylalanine (L-Dopa) Treatment in the Neuroendocrine Response to Stress [PDF]

open access: gold, 2021
Santiago Jordi Orrillo   +10 more
openalex   +1 more source

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