Results 161 to 170 of about 9,926 (263)

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Liquiritigenin-Rich Hydroalcoholic Extract of Brazilian Red Propolis Reduces Dyskinesia Induced by 3,4- Dihydroxyphenylalanine in Hemiparkinsonian Rats. [PDF]

Basic Clin Pharmacol Toxicol
da Silva Barroso S, Lopes LES, Dos Santos AMG, Neto RVB, Dos Santos Lima B, de Souza Araújo AA, Cardoso JC, Severino P, Souto EB, Gomes MZ.   +9 more
europepmc   +1 more source

Behavioral Phenotyping of the Pahenu2 Mouse Model for Phenylketonuria—A Scoping Review and Future Perspectives

Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
ABSTRACT Phenylketonuria (PKU) is a rare metabolic disorder resulting from a mutation in the gene encoding the enzyme phenylalanine hydroxylase (PAH), resulting in very high phenylalanine (Phe) levels in blood and brain. A PKU mutant mouse model was developed via N‐ethyl‐N‐nitrosourea (ENU) mutagenesis, mimicking the high brain Phe content seen in ...
Junfei Cao, Lennart Kruizinga, Iris B. Hovens, Els van der Goot, Robbert Havekes, Eddy A. van der Zee   +5 more
wiley   +1 more source

To test or not to test: what we have learnt from 50 years of dynamic testing in acromegaly. [PDF]

Pituitary
De Marinis L, Chiloiro S, Mancini A, Giambò P, Giampietro A, Bianchi A, Pontecorvi A, Giustina A.   +7 more
europepmc   +1 more source

No Significant Secondary Structural Change of α‐Synuclein Monomer by Site‐Specific DOPA or Phosphorylation Introduction in Its C‐Terminal Region

Journal of Peptide Science, Volume 32, Issue 9, September 2026.
Site‐specifically modified α‐synuclein containing DOPA or phosphorylation was prepared by ligation of a bacterially expressed N‐terminal polypeptide and a synthetic C‐terminal modified peptide. ABSTRACT α‐Synuclein (αSyn) is a major component of pathogenic Lewy bodies and Lewy neurites and is closely associated with Parkinson's disease.
Tatsuhito Matsuo, Isao Suetake, Mariko Kimura, Satoshi Hashimoto, Koichi Matsuo, Sakiko Matsumoto, Shinji Hirotsune, Hironobu Hojo   +7 more
wiley   +1 more source

Dopamine System Dysfunction in Alzheimer's Disease. [PDF]

Psychogeriatrics
Moreira IP, Vieira-Coelho MA, Guimarães J.   +2 more
europepmc   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Antioxidant, Anti-Melanogenic, and Anti-Aging Activities of the Aqueous-Ethanolic Dry Extract of <i>Rosa lucieae</i> with Phytochemical Profiling. [PDF]

Antioxidants (Basel)
Park YG, Kim JY, Ko SC, Kim KW, Yang D, Jo DM, Lee HG, Lee JM, Yim MJ, Kim CH, Lee DS, Kim HS, Oh GW.   +12 more
europepmc   +1 more source

Decoding chemical profiles in insect‐induced gall development: Insights from Phacopteron lentiginosum–Garuga pinnata interactions

Entomological Science, Volume 29, Issue 3, September 2026.
Analysis of volatile and non‐volatile metabolites across three developmental stages (3rd, 4th and 5th instar nymphal stages) of leaf galls induced by Phacopteron lentiginosum on Garuga pinnata revealed that the 3rd stage exhibited the highest chemical diversity and concentration followed by 4th and 5th stages.
V. K. Bobika, M. Nasser, K. S. Shameer
wiley   +1 more source

Multiple transitions to high l-DOPA 4,5-dioxygenase activity reveal molecular pathways to convergent betalain pigmentation in Caryophyllales. [PDF]

New Phytol
Walker-Hale N, Guerrero-Rubio MA, Brockington SF.   +2 more
europepmc   +1 more source