Results 1 to 10 of about 112,750 (306)

Catecholamine Derivatives as Novel Crosslinkers for the Synthesis of Versatile Biopolymers

Journal of Functional Biomaterials, 2023
Catecholamine metabolites are not only involved in primary metabolism, but also in secondary metabolism, serving a diverse array of physiologically and biochemically important functions. Melanin, which originates from dopa and dopamine, found in the hair,
Manickam Sugumaran, Jason J. Evans
doaj   +1 more source

Curcumin-driven reprogramming of the gut microbiota and metabolome ameliorates motor deficits and neuroinflammation in a mouse model of Parkinson’s disease

Frontiers in Cellular and Infection Microbiology, 2022
BackgroundParkinson’s disease (PD) is a common neurodegenerative disorder, accompanied by motor deficits as well as gastrointestinal dysfunctions.
Can Cui, Yingying Han, Hongxia Li, Hongxiang Yu, Bei Zhang, Gang Li   +5 more
doaj   +1 more source

A promising material for bone repair: PMMA bone cement modified by dopamine-coated strontium-doped calcium polyphosphate particles [PDF]

Royal Society Open Science, 2019
Polymethyl methacrylate (PMMA) bone cement has been widely used in clinics as bone repair materials for its excellent mechanical properties and good injection properties. However, it also has defects such as poor biological performance, high temperature,
Xing Liu, Can Cheng, Xu Peng, Hong Xiao, Chengrui Guo, Xu Wang, Li Li, Xixun Yu   +7 more
doaj   +1 more source

Reactions of DOPA (3,4-dihydroxyphenylalanine) decarboxylase with DOPA [PDF]

Biochemical Journal, 1979
The study of DOPA (3,4-dihydroxyphenylalanine) decarboxylase by steady-state methods is difficult because multiple reactions occur. The reaction with DOPA was studied at enzyme concentrations between 20 and 50 micrometer by direct observation of the bound coenzyme by using stopped-flow and conventional spectrophotometry. Four processes were observed on
A. Minelli, A. T. Charteris, VOLTATTORNI, Carla, R. A. John   +3 more
openaire   +3 more sources

Pyrylium based derivatization imaging mass spectrometer revealed the localization of L-DOPA.

PLoS ONE, 2022
Simultaneous imaging of l-dihydroxyphenylalanine (l-DOPA), dopamine (DA) and norepinephrine (NE) in the catecholamine metabolic pathway is particularly useful because l-DOPA is a neurophysiologically important metabolic intermediate.
Shu Taira, Akari Ikeda, Yuki Sugiura, Hitomi Shikano, Shoko Kobayashi, Tsutomu Terauchi, Jun Yokoyama   +6 more
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D-DOPA Is a Potent, Orally Bioavailable, Allosteric Inhibitor of Glutamate Carboxypeptidase II

Pharmaceutics, 2022
Glutamate carboxypeptidase-II (GCPII) is a zinc-dependent metalloenzyme implicated in numerous neurological disorders. The pharmacophoric requirements of active-site GCPII inhibitors makes them highly charged, manifesting poor pharmacokinetic (PK ...
Sadakatali S. Gori, Ajit G. Thomas, Arindom Pal, Robyn Wiseman, Dana V. Ferraris, Run-duo Gao, Ying Wu, Jesse Alt, Takashi Tsukamoto, Barbara S. Slusher, Rana Rais   +10 more
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Simultaneous Determination of Levodopa and Carbidopa from Fava Bean, Green Peas and Green Beans by High Performance Liquid Gas Chromatography [PDF]

Journal of Clinical and Diagnostic Research, 2013
Introduction: According to many studies, sprouted fava beans are a rich source of levo-dihydroxy phenylalanine (L-dopa) the precursor of dopamine, and they are now being investigated for use in the management of Parkinson’s disease.
Mohseni Mehran S.M., Golshani B.
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Irreversible incorporation of L-dopa into the C-terminus of α-tubulin inhibits binding of molecular motor KIF5B to microtubules and alters mitochondrial traffic along the axon

Neurobiology of Disease, 2021
L-dopa is the most effective drug used to date for management of Parkinson's disease symptoms. Unfortunately, long-term administration of L-dopa often results in development of motor disorders, including dyskinesias.
Agustina Zorgniotti, Yanina Ditamo, Carlos A. Arce, C. Gaston Bisig   +3 more
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Surface modification of patterned electrospun nanofibrous films via the adhesion of DOPA-bFGF and DOPA-ponericin G1 for skin wound healing

Materials & Design, 2020
Combining biodegradable materials with bioactive factors for skin wound healing has been receiving significant attention. This study was inspired by the adhesion mechanism of a marine organism, the mussel. 3,4-Dihydroxyphenylalanine (DOPA) was introduced
Jing Zhan, Hong Xu, Yinghui Zhong, Qianqian Wu, Zhenning Liu   +4 more
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Effects of L-dopa and p-coumaric acid combination on oxidative stress, DNA damage, and mitochondrial apoptosis in neuroblastoma cells

Bangladesh Journal of Pharmacology, 2023
This study aimed to investigate the effects of levodopa (L-dopa), p-coumaric acid, and combinations in the neuroblastoma (N1E-115) cell. L-dopa and L-dopa plus p-coumaric acid group caused oxidative stress by increasing 12.5 and 3.7-fold in superoxide ...
Nebiye Pelin Turker, Elvan Bakar
doaj   +1 more source