Results 11 to 20 of about 101,529 (354)
Science Advances, 2021 l-DOPA–induced dyskinesia is caused by elevated l-DOPA levels and dysregulated l-DOPA metabolism throughout the brain. l-DOPA treatment for Parkinson’s disease frequently leads to dyskinesias, the pathophysiology of which is poorly understood.
Elva Fridjonsdottir +10 more
semanticscholar +2 more sources
L-Dopa and Schizophrenia [PDF]
Canadian Psychiatric Association Journal, 1976 Previous reports have emphasized the deterioration of schizophrenic patients when given L-Dopa. The authors described a patient with long-standing catatonic schizophrenia who was not helped by conventional therapies but initially responded dramatically to L-Dopa.
P E, Garfinkel, H C, Stancer
openaire +3 more sources
Inactivation of Tyrosinase by Dopa [PDF]
Journal of Investigative Dermatology, 1980 Tyrosinase in a melanosome is known to be inactivated during melanin formation in vivo, and a similar inactivation was observed in vitro when melanosomes isolated from Harding Passey mouse melanoma were incubated with dopa. Tyrosinase, whether particle bound or in soluble form, was inactivated during the dopa-tyrosinase reaction and the reduction rate ...
Tomita, Yasushi +3 more
openaire +3 more sources
l-Dopa and Brain Serotonin System Dysfunction
Toxics, 2015 l-dopa is used to treat the motor symptoms associated with Parkinson’s disease, a neurodegenerative movement disorder characterized by a loss of dopamine neurons.
Branden J. Stansley, B. Yamamoto
semanticscholar +2 more sources
Signal Transduction and Targeted Therapy, 2021 The phenylalanine–tyrosine–dopa–dopamine pathway provides dopamine to the brain. In this process, tyrosine hydroxylase (TH) is the rate-limiting enzyme that hydroxylates tyrosine and generates levodopa (l-dopa) with tetrahydrobiopterin (BH4) as a ...
Yan Wang +19 more
semanticscholar +1 more source
Angewandte Chemie, 2021 Levodopa (L-Dopa) is the ‘gold-standard’ medication for symptomatic therapy of Parkinson disease (PD). However, L-Dopa long-term use is associated with the development of motor and non-motor complications, primarily due to its fluctuating plasma levels ...
Jong-Min Moon +9 more
semanticscholar +1 more source
Advances in Materials, 2021 The underwater adhesive prowess of aquatic mussels has been largely attributed to the abundant post‐translationally modified amino acid l‐3,4‐dihydroxyphenylalanine (Dopa) in mussel foot proteins (MFPs) that make up their adhesive threads. More recently,
K. Deepankumar +7 more
semanticscholar +1 more source
Molecular design principles of Lysine-DOPA wet adhesion
Nature Communications, 2020 The mussel byssus has long been a source of inspiration for the adhesion community. Recently, adhesive synergy between flanking lysine (Lys, K) and 3,4-Dihydroxyphenylalanine (DOPA, Y) residues in the mussel foot proteins (Mfps) has been highlighted ...
Yiran Li +7 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Catechol chemistry has emerged as a cornerstone of bioinspired polymers and adhesives due to its versatility in creating diverse covalent and dynamic noncovalent interactions (including metal coordination).
Tobias Priemel +5 more
semanticscholar +1 more source
L-DOPA functions as a plant pheromone for belowground anti-herbivory communication [PDF]
, 2023 While mechanisms of plant–plant communication for alerting neighbouring plants of an imminent insect herbivore attack have been described aboveground via the production of volatile organic compounds (VOCs), we are yet to decipher the specific components ...
Pickett, J. A. +20 more
core +1 more source