Results 21 to 30 of about 58,036 (310)
D-DOPA Is a Potent, Orally Bioavailable, Allosteric Inhibitor of Glutamate Carboxypeptidase II
Pharmaceutics, 2022 Glutamate carboxypeptidase-II (GCPII) is a zinc-dependent metalloenzyme implicated in numerous neurological disorders. The pharmacophoric requirements of active-site GCPII inhibitors makes them highly charged, manifesting poor pharmacokinetic (PK ...
Sadakatali S. Gori +10 more
doaj +1 more source
Simultaneous Determination of Levodopa and Carbidopa from Fava Bean, Green Peas and Green Beans by High Performance Liquid Gas Chromatography [PDF]
Journal of Clinical and Diagnostic Research, 2013 Introduction: According to many studies, sprouted fava beans are a rich source of levo-dihydroxy phenylalanine (L-dopa) the precursor of dopamine, and they are now being investigated for use in the management of Parkinson’s disease.
Mohseni Mehran S.M., Golshani B.
doaj +1 more source
Neurobiology of Disease, 2021 L-dopa is the most effective drug used to date for management of Parkinson's disease symptoms. Unfortunately, long-term administration of L-dopa often results in development of motor disorders, including dyskinesias.
Agustina Zorgniotti +3 more
doaj +1 more source
Materials & Design, 2020 Combining biodegradable materials with bioactive factors for skin wound healing has been receiving significant attention. This study was inspired by the adhesion mechanism of a marine organism, the mussel. 3,4-Dihydroxyphenylalanine (DOPA) was introduced
Jing Zhan +4 more
doaj +1 more source
, 2022 The pharmacological manipulation of neuroinflammation appears to be a promising strategy to alleviate l-DOPA-induced dyskinesia (LID) in Parkinson’s disease (PD).
Patrick Pierre Michel (2019922) +5 more
core +1 more source
The Digital Observatory for Protected Areas (DOPA) Explorer 1.0 [PDF]
, 2015 The Digital Observatory for Protected Areas (DOPA) has been developed to support the European Union’s efforts in strengthening our capacity to mobilize and use biodiversity data, information and forecasts so that they are readily accessible to ...
Martinez-Lopez, Javier +6 more
core +1 more source
An Overview of Methods for L-Dopa Extraction and Analytical Determination in Plant Matrices
Separations, 2022 L-dopa is a precursor of dopamine used as the most effective symptomatic drug treatment for Parkinson’s disease. Most of the L-dopa isolated is either synthesized chemically or from natural sources, but only some plants belonging to the Fabaceae family ...
Carmen Tesoro +5 more
doaj +1 more source
Secretion of Dopa in Phaeochromocytoma [PDF]
BMJ, 1972 In a series of 11 cases with phaeochromocytoma, two patients were found in whom the tumour secreted dopa in addition to dopamine, noradrenaline, and adrenaline. These two patients were normotensive in spite of high plasma and urinary levels of noradrenaline and adrenaline.
W J, Louis +3 more
openaire +2 more sources
Purification, Characterization and Biological Activity of Polysaccharides from Dendrobium officinale
Molecules, 2016 Polysaccharide (DOPA) from the stem of D. officinale, as well as two fractions (DOPA-1 and DOPA-2) of it, were isolated and purified by DEAE cellulose-52 and Sephacryl S-300 chromatography, and their structural characteristics and bioactivities were ...
Kaiwei Huang +6 more
doaj +1 more source
Low-dose levodopa protects nerve cells from oxidative stress and up-regulates expression of pCREB and CD39. [PDF]
PLoS ONE, 2014 OBJECTIVE: This study aimed to investigate the influence of low-dose levodopa (L-DOPA) on neuronal cell death under oxidative stress. METHODS: PC12 cells were treated with L-DOPA at different concentrations. We detected the L-DOPA induced reactive oxygen
Shi-Ying Zhong +5 more
doaj +1 more source