Results 31 to 40 of about 101,529 (354)

Enhanced expression of genes in the brains of larvae of Mamestra brassicae (Lepidoptera: Noctuidae) exposed to short daylength or fed Dopa

European Journal of Entomology, 2003
The cabbage armyworm, Mamestra brassicae, enters diapause in the early pupal stage. Pupal diapause is induced by rearing the larvae under short day lengths.
Masahide URYU, Yohsuke NINOMIYA, Takeshi YOKOI, Seiji TSUZUKI, Yoichi HAYAKAWA   +4 more
doaj   +1 more source

Suppressive Effect of Tetrahydrobiopterin on L-β-( 3,4-Dihydroxyphenyl) alanine-Induced Cytotoxicity in PC-12 Cells

Pteridines, 1997
We examined the inhibitory effect of tetrahydrobiopterin (BPH4) on L-β-(3,4-dihydroxyphenyl)alanine (DOPA)-induced cytotoxicity in PC-12 cells. First in vitro inhibitory efficacy of BPH4 on lipid peroxidation induced by Fe3+-DOPA complex was confirmed by
Kojima Shuji, Kugenuma Hiroshi, Oyobe Sayaka, lizuka Hiroyuki, Ikekita Masahiko   +4 more
doaj   +1 more source

Uso precoce e tardio de dopamina após isquemia miocárdica Early and late use of dopamine after myocardial ischemia

Brazilian Journal of Cardiovascular Surgery, 2004
OBJETIVO: Avaliar os efeitos na função ventricular esquerda do uso precoce e tardio de dopamina, em modelo experimental de coração isolado. MÉTODO: Foram utilizados 60 coelhos em modelo de coração isolado mantido por animal suporte.
Ademar R. Souza, Marcos A. M. Silva, Rubens R. Andrade, Reinaldo A. Oliveira, Antônio S. Martins   +4 more
doaj   +1 more source

Polymorphism of the Dopa-Decarboxylase Gene Modifies the Motor Response to Levodopa in Chinese Patients With Parkinson's Disease

Frontiers in Neurology, 2020
Levodopa (L-DOPA) is the most effective drug for Parkinson's disease (PD). However, the response to L-DOPA remains individually variable, which hampers the practical value of L-DOPA in the clinic. Genetic factors play a role in L-DOPA efficacy.
Lanting Li, Huixia Lin, Ping Hua, Lei Yan, Hui Dong, Tan Li, Weiguo Liu   +6 more
doaj   +1 more source

L-DOPA in Parkinson’s Disease: Looking at the “False” Neurotransmitters and Their Meaning

International Journal of Molecular Sciences, 2019
L-3,4-dihydroxyphenylalanine (L-DOPA) has been successfully used in the treatment of Parkinson’s disease (PD) for more than 50 years. It fulfilled the criteria to cross the blood–brain barrier and counteract the biochemical defect of dopamine (DA).
A. Chagraoui, Marie Boulain, Laurent Juvin, Y. Anouar, G. Barrière, P. De Deurwaerdère   +5 more
semanticscholar   +1 more source

Plasma 3-O-Methyldopa Concentration Monitoring for Treatment Optimization in Foslevodopa/Foscarbidopa Infusion: Implications for Corrected Levodopa Availability: A Case Report. [PDF]

Mov Disord Clin Pract
Movement Disorders Clinical Practice, EarlyView.
Okusa S, Okada K, Nihei Y, Sakai R, Akiyoshi T, Nukariya T, Nakahara J, Ohtani H, Seki M.   +8 more
europepmc   +2 more sources

L-DOPA functionalized, multi-branched gold nanoparticles as brain-targeted nano-vehicles.

Nanomedicine: Nanotechnology, Biology and Medicine, 2019
The blood-brain barrier (BBB) is a protective endothelial barrier lining the brain microvasculature which prevents brain delivery of therapies against brain diseases.
Daniel Gonzalez-Carter, Z. Ong, C. McGilvery, I. Dunlop, D. Dexter, A. Porter   +5 more
semanticscholar   +1 more source

Striatal astrocytes act as a reservoir for L-DOPA.

PLoS ONE, 2014
L-DOPA is therapeutically efficacious in patients with Parkinson's disease (PD), although dopamine (DA) neurons are severely degenerated. Since cortical astrocytes express neutral amino acid transporter (LAT) and DA transporter (DAT), the uptake and ...
Masato Asanuma, Ikuko Miyazaki, Shinki Murakami, Francisco J Diaz-Corrales, Norio Ogawa   +4 more
doaj   +1 more source

An Overview of Methods for L-Dopa Extraction and Analytical Determination in Plant Matrices

Separations, 2022
L-dopa is a precursor of dopamine used as the most effective symptomatic drug treatment for Parkinson’s disease. Most of the L-dopa isolated is either synthesized chemically or from natural sources, but only some plants belonging to the Fabaceae family ...
Carmen Tesoro, Filomena Lelario, Rosanna Ciriello, Giuliana Bianco, Angela Di Capua, Maria Assunta Acquavia   +5 more
doaj   +1 more source

Evolution of l‐DOPA 4,5‐dioxygenase activity allows for recurrent specialisation to betalain pigmentation in Caryophyllales

New Phytologist, 2019
Summary The evolution of l‐DOPA 4,5‐dioxygenase activity, encoded by the gene DODA, was a key step in the origin of betalain biosynthesis in Caryophyllales.
Hester Sheehan, Tao Feng, Nathanael Walker-Hale, Samuel Lopez-Nieves, Boas Pucker, Rui Guo, Won Yim, Roshani Badgami, Alfonso Timoneda, Lijun Zhao, Helene C Tiley, D. Copetti, M. Sanderson, J. Cushman, Michael J Moore, Stephen A. Smith, Samuel F. Brockington   +16 more
semanticscholar   +1 more source