Results 271 to 280 of about 25,647 (343)

Radical sequestration by protein-bound 3,4-dihydroxyphenylalanine

The International Journal of Biochemistry & Cell Biology, 2010
Protein-bound 3,4-dihydroxyphenylalanine (PB-DOPA), a redox-active product of protein oxidation, is capable of functioning as both a pro- and antioxidant. A number of in vitro and in vivo studies have demonstrated a toxic, non-toxic or even beneficial effect of free DOPA, however little investigation has examined the physiological activity of PB-DOPA ...
Nelson, Michelle, Foxwell, Alice R., Tyrer, Peter, Dean, Roger T.   +3 more
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Clinical experience with dihydroxyphenylalanine (DOPA) in depression

Journal of Psychiatric Research, 1963
THIS is a report of the rGsults of a clinical trial of dihydroxyphenylalanine (DOPA), a precursor of catechol amines, in the treatment of depression. This experiment was undertaken as an indirect test of the catechol amine theory of affective disorders, which proposes that depressed patients have an absolute or relative deficiency of central nervous ...
G L, KLERMAN, J J, SCHILDKRAUT, L L, HASENBUSH, M, GREENBLATT, D G, FRIEND   +4 more
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Molecular mechanics of dihydroxyphenylalanine at a silica interface

, 2012
L-3,4-dihydroxyphenylalanine (DOPA) is an amazing biological glue secreted by marine mussels. Through enhanced sampling molecular dynamics, here we demonstrate that proteins with DOPA residues have a strong affinity to a silica surface with an ...
Zhao Qin, M. Buehler
semanticscholar   +1 more source

ChemInform Abstract: SYNTHESES OF α‐ETHYNYL‐3,4‐DIHYDROXYPHENYLALANINE AND α‐VINYL‐3,4‐DIHYDROXYPHENYLALANINE

Chemischer Informationsdienst, 1977
Abstract3,4‐Dihydroxy‐benzoesäureester (I) liefert mit Diphenyldichlormethan den cyclischen Ester (II), der nach Reduktion zum Carbinol (IIIa) ein Benzylchlorid (IIIb) gibt, das mit dem Acetylen‐imin (IV) zu einem Substitutionsprodukt (V) führt.
D. TAUB, A. A. PATCHETT
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The metabolism of L-3,4-dihydroxyphenylalanine in man

Clinica Chimica Acta, 1970
Abstract This study describes the metabolic fate of orally ingested l -3,4-dihydroxy-phenylalanine in four human adults. The amounts of L-DOPA ingested ranged from 3 to 8 g per day. A variety of techniques were employed whereby the acid, amine, and neutral urinary metabolites were determined.
L P, O'Gorman, O, Borud, I A, Khan, L R, Gjessing   +3 more
openaire   +2 more sources

On the presence of dihydroxyphenylalanine decarboxylase in nerves

Experientia, 1964
Durchtrennung des Ruckenmarks fuhrt zu einer Verminderung der Aktivitat des Enzymsl-3,4-Dihydroxyphenylalanin-decarboxylase (DOPA-Decarboxylase) in den kaudalen Teilen um 75% (in-vivo-Werte) bis 95% (in-vitro-Werte). Die Decarboxylaseaktivitat in der Rattenmilz wird nach Exzision des Ganglion Coeliacum ebenfalls erheblich vermindert.
N E, Andén, T, Magnusson, E, Rosengren
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Liquid chromatographic resolution of racemic β-3,4-dihydroxyphenylalanine

Journal of Chromatography A, 1971
Abstract The d and l -isomer sof β-3,4-dihydroxyphenylalanine were effectively resolved by liquid chromatography. The separation was best accomplished using an asymmetric support prepared by bonding l -arginine through a cyanuric chloride linkage to Sephadex G-25.
R J, Baczuk, G K, Landram, R J, Dubois, H C, Dehm   +3 more
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Enzymatic decarboxylation of isomers and derivatives of dihydroxyphenylalanine

Archives of Biochemistry and Biophysics, 1952
Abstract 1. 1. The substrate specificities of tyrosine decarboxylase of Streptococcus faecalis R and of dihydroxyphenylalanine (DOPA) decarboxylase of pig and guinea pig kidney have been studied. 2. 2. The quantitative data reveal that interaction between substituents on the benzene ring of the substrates, as well as the position of the ...
T, SOURKES, P, HENEAGE, Y, TRANO
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Simultaneous Determination of 3,4‐Dihydroxyphenylalanine, 5‐Hydroxytryptophan, Dopamine, 4‐Hydroxy‐3‐Methoxyphenylalanine, Norepinephrine, 3,4‐Dihydroxyphenylacetic Acid, Homovanillic Acid, Serotonin, and 5‐Hydroxyindoleacetic Acid in Rat Cerebrospinal Fluid and Brain by High‐Performance Liquid Chro

Journal of Neurochemistry, 1982
: A method using reversed‐phase ion‐pair high‐performance liquid chromatography with electrochemical detection for the simultaneous determination of tryptophan (TRP), 3,4‐dihydroxyphenylalanine (DOPA), and their metabolites in whole brain, small‐brain ...
J. Wagner, P. Vitali, M. Palfreyman, M. Zraika, Stéphane Huot   +4 more
semanticscholar   +1 more source

Does 3,4-Dihydroxyphenylalanine Play a Part in Favism?

Nature, 1967
FAVISM is a haemolytic anaemia precipitated in some glucose-6-phosphate dehydrogenase (G-6-PD) deficient individuals by the ingestion of fava beans. Although the mechanism of haemolysis in G-6-PD deficient individuals has not been elucidated, it is generally thought that the destruction of reduced glutathione (GSH) is associated with the events which ...
N S, Kosower, E M, Kosower
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