Results 211 to 220 of about 9,923 (262)

3, 4-Dihydroxyphenylalanine and Related Compounds

1966
This review covers essentially derivatives of β-phenyl-α-alanine which contain two phenolic hydroxyl groups, and some of their analogs and derivatives. They comprise β-(3, 4-dihydroxyphenyl)-α-alanine (dopa) and the few known ethers and ring substituted derivatives of this amino acid, as well as derivatives of dopa substituted in the alanine group ...
A R, Patel, A, Burger
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Enzymatic decarboxylation of isomers and derivatives of dihydroxyphenylalanine

Archives of Biochemistry and Biophysics, 1952
Abstract 1. 1. The substrate specificities of tyrosine decarboxylase of Streptococcus faecalis R and of dihydroxyphenylalanine (DOPA) decarboxylase of pig and guinea pig kidney have been studied. 2. 2. The quantitative data reveal that interaction between substituents on the benzene ring of the substrates, as well as the position of the ...
T, SOURKES, P, HENEAGE, Y, TRANO
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Metabolism of Dihydroxyphenylalanine in Human Subjects

Nature, 1967
THE metabolism of dihydroxyphenylalanine (DOPA; I, R = H) may be very complex. By analogy with other amino-acids, degradation may involve decarboxylation (route A) or transamination (route B), with methylation of the 3-hydroxy group possible at any stage. The principal metabolite in normal human urine appears to be homovanillic acid (HVA; III, R = CH3),
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The influence of imipramine on the central effects of dihydroxyphenylalanine

Neuropharmacology, 1970
Abstract A study was made in animals with chronically implanted electrodes, and in acute experiments, in order to analyze the influence of imipramine (IM) on the EEG effects of dihydroxyphenylalanine (DOPA). The following results have been obtained: 1. (1) IM potentiated the awakening effect of DOPA in reserpinized cats.
K, Kadzielawa, E, Widy
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Clinical experience with dihydroxyphenylalanine (DOPA) in depression

Journal of Psychiatric Research, 1963
THIS is a report of the rGsults of a clinical trial of dihydroxyphenylalanine (DOPA), a precursor of catechol amines, in the treatment of depression. This experiment was undertaken as an indirect test of the catechol amine theory of affective disorders, which proposes that depressed patients have an absolute or relative deficiency of central nervous ...
G L, KLERMAN, J J, SCHILDKRAUT, L L, HASENBUSH, M, GREENBLATT, D G, FRIEND   +4 more
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Electroencephalographic analysis of the central action of dihydroxyphenylalanine

Electroencephalography and Clinical Neurophysiology, 1970
Abstract 1. 1. The EEG effects of DOPA were analysed in cats, depending upon the level of brain-stem section. 2. 2. In contrast with cats with chronically implanted electrodes, gallamine-immobilized, and with encephale isole cats, in which DOPA is unable to induce profound changes in the EEG pattern and behaviour, this amino acid elicits an
K, Kadzielawa, E, Widy-Tyszkiewicz
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ChemInform Abstract: SYNTHESES OF α‐ETHYNYL‐3,4‐DIHYDROXYPHENYLALANINE AND α‐VINYL‐3,4‐DIHYDROXYPHENYLALANINE

Chemischer Informationsdienst, 1977
Abstract3,4‐Dihydroxy‐benzoesäureester (I) liefert mit Diphenyldichlormethan den cyclischen Ester (II), der nach Reduktion zum Carbinol (IIIa) ein Benzylchlorid (IIIb) gibt, das mit dem Acetylen‐imin (IV) zu einem Substitutionsprodukt (V) führt.
D. TAUB, A. A. PATCHETT
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Syntheses of α-ethynyl-3, 4-dihydroxyphenylalanine and α-vinyl-3, 4-dihydroxyphenylalanine

Tetrahedron Letters, 1977
3,4-Dihydroxy-benzoesaureester (I) liefert mit Diphenyldichlormethan den cyclischen Ester (II), der nach Reduktion zum Carbinol (IIIa) ein Benzylchlorid (IIIb) gibt, das mit dem Acetylen-imin (IV) zu einem Substitutionsprodukt (V) fuhrt.
D. Taub, A.A. Patchett
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The Cerebral Metabolism of L-Dihydroxyphenylalanine

Pharmacology, 2008
The regional cerebral distribution of carbon-14 activity was studied using auto-radiography following the intravenous administration of L-3,4-dihydroxyphenyl-(3-14C)-ala-nine (14C-L-dopa) to rats pretreated with carbidopa. 5 min after 14C-L-dopa administration, the regional cerebral distribution of carbon-14 varied with regional cerebral blood flow ...
M.K. Horne, C.H. Cheng, G.F. Wooten
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ENZYMATIC DECARBOXYLATION OF 2,6- AND 2,3-DIHYDROXYPHENYLALANINE

Canadian Journal of Biochemistry and Physiology, 1954
The action of dihydroxyphenylalanine (dopa) decarboxylase of guinea pig kidney and of tyrosine decarboxylase of Streptococcus faecalis R on 2,3- and 2,6-dopa has been studied. Compared with 3,4-dopa, these substrates are decarboxylated by the kidney enzyme at rates decreasing in the order: 2,3-, 3,4-, 2,6-dopa.
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