Results 21 to 30 of about 9,923 (262)

Genetic associations of single nucleotide polymorphisms in the l-DOPA receptor (GPR143) gene with severity of nicotine dependence in Japanese individuals, and attenuation of nicotine reinforcement in Gpr143 gene-deficient mice

Journal of Pharmacological Sciences, 2020
l-3,4-dihydroxyphenylalanine (l-DOPA) is a candidate neurotransmitter. l-DOPA is released by nicotine through nicotinic receptors. Recently, G-protein coupled receptor GPR143, was identified as a receptor for l-DOPA.
Daiki Masukawa, Daisuke Nishizawa, Kaori Kanai, Satoshi Kitamura, Yuka Kasahara, Tatsuo Hashimoto, Ryo Takahagi, Junko Hasegawa, Kyoko Nakayama, Naomi Sato, Fumihiko Tanioka, Haruhiko Sugimura, Kazutaka Ikeda, Yoshio Goshima   +13 more
doaj   +1 more source

Early diagnosis of focal congenital hyperinsulinism: A fluorine-18-labeled l-dihydroxyphenylalanine positron emission tomography/computed tomography study

World Journal of Nuclear Medicine, 2021
Congenital hyperinsulinism (CHI) is responsible for hyperinsulinemic hypoglycemia which needs aggressive treatment in order to prevent neurological damages.
Luca Burroni, Andrea Palucci, Giuseppina Biscontini, Valentino Cherubini   +3 more
doaj   +1 more source

Efficient production of salvianic acid A from l-dihydroxyphenylalanine through a tri-enzyme cascade

Bioresources and Bioprocessing, 2023
Salvianic acid A (SAA), used for treating cardiovascular and cerebrovascular diseases, possesses several pharmacological properties. However, the current methods for the enzymatic synthesis of SAA show low efficiency.
Jiahui Yang, Wanqing Wei, Changzheng Gao, Wei Song, Cong Gao, Xiulai Chen, Jia Liu, Liang Guo, Liming Liu, Jing Wu   +9 more
doaj   +1 more source

Effect of Selective Serotonin Reuptake Inhibitors via 5-HT1A Receptors on L-DOPA-Induced Rotational Behavior in a Hemiparkinsonian Rat Model

Journal of Pharmacological Sciences, 2012
l-Dihydroxyphenylalanine (l-DOPA) is considered the gold standard for the treatment of Parkinson’s disease (PD). However, long-term administration of l-DOPA can induce abnormal side effects.
Masatoshi Inden, Mari Abe, Hideaki Minamino, Kazuyuki Takata, Kanji Yoshimoto, Ikuo Tooyama, Yoshihisa Kitamura   +6 more
doaj   +1 more source

The Use of the Calcitonin Minimal Recognition Module for the Design of DOPA-Containing Fibrillar Assemblies

Nanomaterials, 2014
Amyloid deposits are insoluble fibrous protein aggregates, identified in numerous diseases, which self-assemble through molecular recognition. This process is facilitated by short amino acid sequences, identified as minimal modules.
Galit Fichman, Tom Guterman, Lihi Adler-Abramovich, Ehud Gazit   +3 more
doaj   +1 more source

Silk/Natural Rubber (NR) and 3,4-Dihydroxyphenylalanine (DOPA)-Modified Silk/NR Composites: Synthesis, Secondary Structure, and Mechanical Properties

Molecules, 2020
Silk composites with natural rubber (NR) were prepared by mixing degummed silk and NR latex solutions. A significant enhancement of the mechanical properties was confirmed for silk/NR composites compared to a NR-only product, indicating that silk can be ...
Hiromitsu Sogawa, Treratanakulwongs Korawit, Hiroyasu Masunaga, Keiji Numata   +3 more
doaj   +1 more source

Synthesis of the Isodityrosine Moiety of Seongsanamide A–D and Its Derivatives

Marine Drugs, 2023
The concise and highly convergent synthesis of the isodityrosine unit of seongsanamide A–D and its derivatives bearing a diaryl ether moiety is described.
Yang Xie, Zhou Xu, Pei Hu, Xiao-Ting Tian, Yi-Hong Lu, Hao-Dong Jiang, Cheng-Gang Huang, Zhi-Cai Shang   +7 more
doaj   +1 more source

l-3,4-Dihydroxyphenylalanine induces ptosis through a GPR143-independent mechanism in mice

Journal of Pharmacological Sciences, 2016
Through its conversion to dopamine by aromatic l-amino acid decarboxylase (AADC), l-3,4-dihydroxyphenylalanine (l-DOPA) replenishes depleted brain dopamine in Parkinson's disease patients. We recently identified GPR143 as a candidate receptor for l-DOPA.
Suguru Ueda, Daiki Masukawa, Motokazu Koga, Yoshio Goshima   +3 more
doaj   +1 more source

Rheology and Gelation of Hyaluronic Acid/Chitosan Coacervates

Biomolecules, 2022
Hyaluronic acid (HA) and chitosan (CHI) are biopolyelectrolytes which are interesting for both the medical and polymer physics communities due to their biocompatibility and semi-flexibility, respectively.
A. Basak Kayitmazer, Fatih Comert, Henning H. Winter, Phillip B. Messersmith   +3 more
doaj   +1 more source

Constructing Optical Biosensor Based on Multienzyme System Tyrosinase/Horseradish Peroxidase [PDF]

International Journal Bioautomation, 2015
By using sol-gel method, hybrid membranes were synthesized based on SiO2 and cellulose derivatives. Membranes showed good physical and mechanical properties as well as good biocompatibility.
Lyubov Yotova, Spaska Yaneva
doaj   +2 more sources