Results 101 to 110 of about 3,824 (213)

2,5-Diketopiperazines as Potent, Selective, and Orally Bioavailable Oxytocin Antagonists. 2. Synthesis, Chirality, and Pharmacokinetics

, 2016
A short stereoselective synthesis of a series of chiral 7-aryl-2,5-diketopiperazines oxytocin antagonists is described. Varying the functionality and substitution pattern of substituents in the 7-aryl ring and varying the chirality of this exocyclic ring
Michael J Allen (2665225), Marion Perren (2535571), Paul G. Wyatt (473658), Steve L. Sollis (2119774), Fabrizio Nerozzi (2119777), Anne M. Exall (2119789), Alan D. Borthwick (2119795), David G. Livermore (2535556), Shalia S. Shabbir (2535559), Dave E. Davies (2119768), Patrick M. Woollard (2119804)   +10 more
core   +1 more source

Exploring the Diverse Landscape of Fungal Cytochrome P450‐Catalyzed Regio‐ and Stereoselective Dimerization of Diketopiperazines

Advanced Science
Dimeric indole‐containing diketopiperazines (di‐DKPs) are a diverse group of natural products produced through cytochrome P450‐catalyzed C–C or C–N coupling reactions.
Chuanteng Ma, Wenxue Wang, Kaijin Zhang, Falei Zhang, Yimin Chang, Chunxiao Sun, Qian Che, Tianjiao Zhu, Guojian Zhang, Dehai Li   +9 more
doaj   +1 more source

A NOVEL CLASS OF DIKETOPIPERAZINES

The Journal of Antibiotics, 1973
R L, DeVault, W, Rosenbrook
openaire   +3 more sources

Exploring bat-inspired cyclic tryptophan diketopiperazines as ABCB1 Inhibitors

Communications Chemistry
Chemotherapy-induced drug resistance remains a major cause of cancer recurrence and patient mortality. ATP binding cassette subfamily B member 1 (ABCB1) transporter overexpression in tumors contributes to resistance, yet current ABCB1 inhibitors have ...
Javier Yu Peng Koh, Yoko Itahana, Alexander Krah, Habib Mostafa, Mingmin Ong, Sahana Iwamura, Dona Mariya Vincent, Sabhashina Radha Krishnan, Weiying Ye, Pierre Wing Chi Yim, Tushar M. Khopade, Kunihiko Chen, Pui San Kong, Lin-Fa Wang, Roderick W. Bates, Yasuhisa Kimura, Rajesh Viswanathan, Peter J. Bond, Koji Itahana   +18 more
doaj   +1 more source

Substrate Length Controls Atropopeptide Complexity and Triggers Excision-Driven Scaffold Hop to Diketopiperazine Alkaloids. [PDF]

J Am Chem Soc
Tan B, Cui Z, Kakumu Y, Panczyk SJ, Ikeda M, Liu D, Pestalozzi CM, Vorholt JA, Walker AS, Hardes K, Grininger M, Helfrich EJN.   +11 more
europepmc   +1 more source

Insecticidal metabolites from Serratia marcescens associated with the fall armyworm (Spodoptera frugiperda): molecular identification, metabolomic profiling and molecular docking insights. [PDF]

Sci Rep
El-Lebody KA, El-Ansary RE, Nour SA, Salim RG, Elsebaie MM, El-Sayed GM.   +5 more
europepmc   +1 more source

Effects of Fermentation Period on Metabolite Production and Bioactivity in Two Sponge-Associated Bacteria. [PDF]

Scientifica (Cairo)
Al-Harbi M, Jamal MT, Satheesh S.
europepmc   +1 more source

A Three-Layer Transformation Strategy toward Functionalized Fused Hydantoins and Diketopiperazines. [PDF]

Org Lett
Giannakaki MA, Zingiridis M, Froudas KG, Neochoritis CG.   +3 more
europepmc   +1 more source

Systematic Assessment of the Impact of Targeted Selection Methods and Environment-Mimicking Culture Conditions on Fungal Natural Product Libraries. [PDF]

J Nat Prod
Ness M, Wendt KL, Peramuna T, Tillery DI, Murray JE, Cichewicz RH, McCall LI.   +6 more
europepmc   +1 more source

Antarctic Marine-Derived Fungi: Metabolomic Signatures and Antibiofilm-Driven Anti-Infective Potential Against Drug Resistant Pathogens. [PDF]

Mar Drugs
Uras İS, Candido PHS, Luís CM, Marques V, Rodrigues CMP, Sobral RG, Baurmeister A, Konuklugil B, Gaudêncio SP.   +8 more
europepmc   +1 more source