Results 91 to 100 of about 3,824 (213)

Marine-Derived Rare Actinomycetes: Metabolites and Their Biosynthesis

Marine Drugs
Marine-derived rare actinomycetes are a chemically prolific yet underexploited source of structurally diverse secondary metabolites. In this review, rare actinomycetes are operationally defined as marine-derived non-Streptomyces actinomycetes that remain
Juwan Son, Hyeon Seung Park, Sang Heon Jung, Min Seo Heo, Yun Kwon, Munhyung Bae   +5 more
doaj   +1 more source

A study of diketopiperazines as electron-donor initiators in transition metal-free haloarene-arene coupling [PDF]

, 2017
Several diketopiperazines have been shown to promote carbon-carbon coupling between benzene and aryl halides in the presence of potassium tert-butoxide and without the assistance of a transition metal catalyst.
Cumine, Florimond, Zhou, Shengze, Tuttle, Tell, Florimond Cumine, John A. Murphy, Shengze Zhou, Tell Tuttle, Murphy, John A.   +7 more
core   +1 more source

Prenylated Indole Diketopiperazines from the Marine-Derived Fungus Aspergillus versicolor

, 2016
Seven new prenylated indole diketopiperazines, versicamides A–G (1–7) and a novel chemical derivative from 7, versicamide H (8), along with three known analogic diketopiperazines (9–11) were obtained from the marine-derived fungus Aspergillus versicolor ...
Qianqun Gu (1433620), Jixing Peng (1476112), Huquan Gao (1730467), Dehai Li (1433623), Jing Li (10611), Tianjiao Zhu (1433617), Meiyu Geng (163413), Guojian Zhang (1604386), Jing Ai (271316)   +8 more
core   +1 more source

Escherichia coli GutM4 produces 2,5-diketopiperazines and inhibits human pathogens in vitro [PDF]

, 2018
Background: It has been a very common practice to use probiotics or their metabolites as alternative antimicrobial strategies for the treatment and prevention of infections as rampant and indiscriminate use of antibiotics causes the development of ...
Wang, Yu, Zhang, Xichun, Du, Junmin, Chen, Shuming, Wang, Yingli   +4 more
core  

Restraining Staphylococcus aureus Virulence Factors and Quorum Sensing through Lactic Acid Bacteria Supernatant Extracts

Antibiotics
The escalating prevalence of antibiotic-resistant bacteria poses a grave threat to human health, necessitating the exploration of novel alternatives to conventional antibiotics.
Myriam Anabel Díaz, Esteban Gabriel Vega-Hissi, María Amparo Blázquez, María Rosa Alberto, Mario Eduardo Arena   +4 more
doaj   +1 more source

Structures, sensory activity, and dose/response functions of 2,5-diketopiperazines in roasted cocoa nibs (Theobroma cacao)

, 2005
The taste compounds inducing the blood-like, metallic bitter taste sensation reported recently for a dichloromethane extract prepared from roasted cocoa nibs were identified as a series of 25 diketopiperazines by means of HPLC degustation, LC-MS/MS, and ...
Stark, Timo; Hofmann, Thomas
core   +1 more source

Stereoselective ring contraction of 2,5-diketopiperazines : An innovative approach to the synthesis of promising bioactive 5-membered scaffolds

, 2010
International audienceRing contraction of 2,5-diketopiperazines by TRAL-alkylation led us to the stereoselective synthesis of original pyrrolidine-2,4-diones, a novel series of promising molecules with moderate antiproliferative activity on breast cancer
Parrot, Isabelle, Coursindel, Thilbault, Martinez, Jean, Dewynter, Georges, Restouin, Audrey, Collette, Yves, Yves Collette, Jean Martinez, Isabelle Parrot, Georges Dewynter, Thibault Coursindel, Audrey Restouin   +11 more
core   +1 more source

Inhibition of biofilm in Bacillus amyloliquefaciens Q-426 by diketopiperazines

, 2016
Biofilm formation can make significant effects on bacteria habits and biological functions. In this study, diketopiperazines (DKPs) produced by strain of Bacillus amyloliquefaciens Q-426 was found to inhibit biofilm formed in the gas-liquid interface ...
Quan, CS (reprint author), Dalian Nationalities Univ, Life Sci Coll, Dalian 116600, Peoples R China. Email:jhwang@yic.ac.cn, Yang, CY, Wang, JH, mikyeken@dlnu.edu.cn, Quan, CS, Wang, JH (reprint author), Chinese Acad Sci, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China., Wang, JH (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Marine Environm Corros & Biofouling, Qingdao, Peoples R China., Lu, J, Fang, ST   +8 more
core   +1 more source

Synthesis of functionalized diketopiperazines as cyclotryprostatin and try-prostatin analogues

, 2013
Various ketopiperazines were synthesized as (cyclo)tryprostatin analogues. Construction of the skeleton started with a Pictet-Spengler reaction followed by acylation or alkylation of the piperidine nitrogen and condensation with a primary amine.
Van, Tuyen Nguyen, De Kimpe, Norbert, Claes, Pieter   +2 more
core   +1 more source

Conformationally Assisted Lactamizations for the Synthesis of Symmetrical and Unsymmetrical Bis-2,5-diketopiperazines

, 2016
Open-chain N-Cbz-protected-peptidoyl benzotriazolides are converted by a novel lactamization strategy using proline as a turn introducer into both symmetrical (5a–c and 11a–c) and unsymmetrical (19a–e) bis-2,5-diketopiperazines (bis-2,5-DKPs), previously
Eric Faby (1915771), Iryna Lebedyeva (1830871), Zhiliang Li (278056), Amir Nasajpour (1915765), Girinath G. Pillai (1915762), Abdulrahman O. Al-Youbi (187550), Khanh Ha (1915768), Alan R. Katritzky (455231), Kristin Martin (1915774), Byron Williams (1915777)   +9 more
core   +1 more source