Results 11 to 20 of about 105,621 (227)

Elevated Polyreactive Immunoglobulin G in Immune-Mediated Liver Injuries With the Need for Immunosuppressive Therapy. [PDF]

Liver Int
ABSTRACT Background & Aims The distinction of drug‐induced liver injury (DILI), drug‐induced autoimmune‐like hepatitis (DI‐ALH), and autoimmune hepatitis (AIH) can be challenging due to overlapping clinical characteristics. Recently, polyreactive immunoglobulin G (pIgG) was identified as a novel biomarker in AIH.
Kirchner T, Dalekos GN, Zachou K, Robles-Díaz M, Andrade RJ, Sebode M, Lohse A, Janik MK, Milkiewicz P, Kolev M, Semmo N, Bruns T, Gevers TJ, Beretta-Piccoli BT, Wedemeyer H, Jaeckel E, Taubert R, Engel B, pIgG study group.   +18 more
europepmc   +2 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

DILIConsult: A Multi‐Agent Large Language Model Framework for Evaluating Drug‐Induced Liver Injury in ICU Settings [PDF]

Pharmacotherapy
ABSTRACT Background Large language models (LLMs) can support clinical decision‐making by parsing databases and extracting relevant information. However, evaluating drug‐induced liver injury (DILI) often requires processing lengthy clinical histories alongside reference materials like LiverTox, which can exceed context lengths of conventional LLMs ...
Ho A, Law J, Wang A, Lim D, Ong J.
europepmc   +2 more sources

DILI (drug induced liver injury) in a 9-month-old infant: a rare case of phenobarbital-induced hepatotoxicity

Journal of Pediatric and Neonatal Individualized Medicine, 2013
Phenobarbital is one of the most commonly prescribed antiepileptic drugs in childhood, but it can rarely cause serious adverse effects, such as hepatotoxicity that includes a broad clinical spectrum (from isolate hypertransaminasemia to acute liver ...
Anna Paola Pinna, Gabriella Locci, Maria Furno, Daniela Fanni, Gavino Faa, Anna Maria Nurchi   +5 more
doaj   +1 more source

Amoxicillin-Clavulanate-Induced Liver Injury [PDF]

, 2016
Background and Aims Amoxicillin–clavulanate (AC) is the most frequent cause of idiosyncratic drug-induced injury (DILI) in the US DILI Network (DILIN) registry.
Andrew S. deLemos, David E. Kleiner, Don C. Rockey, Herbert L. Bonkovsky, Huiman X. Barnhart, Jiezhun Gu, Marwan Ghabril, null null, Robert J. Fontana   +8 more
core   +1 more source

A Computational Toxicology Approach to Screen the Hepatotoxic Ingredients in Traditional Chinese Medicines: Polygonum multiflorum Thunb as a Case Study

Biomolecules, 2019
In recent years, liver injury induced by Traditional Chinese Medicines (TCMs) has gained increasing attention worldwide. Assessing the hepatotoxicity of compounds in TCMs is essential and inevitable for both doctors and regulatory agencies.
Shuaibing He, Xuelian Zhang, Shan Lu, Ting Zhu, Guibo Sun, Xiaobo Sun   +5 more
doaj   +1 more source

Immunophenotyping to improve the mechanistic understanding of idiosyncratic drug-induced liver injury: clinical implications and future directions

Exploration of Digestive Diseases, 2023
The late event onset of a fraction of idiosyncratic drug-induced liver injury (DILI) cases and the link observed by genome-wide association studies (GWASs) of certain human leucocyte antigen (HLA) alleles with DILI due to specific drugs support the ...
Alejandro Cueto-Sánchez, Daniel E. Di Zeo-Sánchez, Antonio Segovia-Zafra, Gonzalo Matilla-Cabello, Ana Bodoque-García, María Isabel Lucena, Marina Villanueva-Paz   +6 more
doaj   +1 more source

Drug-induced liver injury: An overview and update

Gastroenterology & Endoscopy, 2023
Drug-induced liver injury (DILI) is a relatively rare but important adverse event for a variety of commonly used drugs, herbal and dietary supplements, illegal drugs and novel agents.
Yujie Wang, Wen Xie
doaj   +1 more source

Update on Advances in Research on Idiosyncratic Drug-Induced Liver Injury [PDF]

, 2015
Drug-induced liver injury (DILI) is a major concern for public health, as well as for drug development in the pharmaceutical industry, since it can cause liver failure and lead to drug withdrawal from the market and black box warnings.
Kim, Seung-Hyun, Naisbitt, Dean J
core   +1 more source