Results 11 to 20 of about 15,827 (239)

Anti-Tubercular Drug-Induced Liver Injury: Current Understanding and Emerging Directions. [PDF]

JGH Open
ABSTRACT Most common adverse effect causing cessation of anti‐tubercular treatment (ATT) is drug‐induced liver injury (DILI) which is unpredictable due to its idiosyncratic nature. ATT is the most common cause of DILI and drug‐induced acute liver failure (ALF) in South East Asia.
Prasad S, Narang H, Kedia S, Ahuja V.
europepmc   +2 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Drug-induced liver injury: An overview and update

Gastroenterology & Endoscopy, 2023
Drug-induced liver injury (DILI) is a relatively rare but important adverse event for a variety of commonly used drugs, herbal and dietary supplements, illegal drugs and novel agents.
Yujie Wang, Wen Xie
doaj   +1 more source

DILI (drug induced liver injury) in a 9-month-old infant: a rare case of phenobarbital-induced hepatotoxicity

Journal of Pediatric and Neonatal Individualized Medicine, 2013
Phenobarbital is one of the most commonly prescribed antiepileptic drugs in childhood, but it can rarely cause serious adverse effects, such as hepatotoxicity that includes a broad clinical spectrum (from isolate hypertransaminasemia to acute liver ...
Anna Paola Pinna, Gabriella Locci, Maria Furno, Daniela Fanni, Gavino Faa, Anna Maria Nurchi   +5 more
doaj   +1 more source

Chronic Drug-Induced Liver Injury: Updates and Future Challenges

Frontiers in Pharmacology, 2021
Chronic drug-induced liver injury (DILI), defined as DILI with persistent liver injury more than one year after the first onset by the latest European guidelines, is a notable challenge globally with big issues of defining causality and establishing ...
Qiaoling Wang, Qiaoling Wang, Ang Huang, Jia-Bo Wang, Jia-Bo Wang, Zhengsheng Zou, Zhengsheng Zou   +6 more
doaj   +1 more source

Increased TG to HDL-C ratio is associated with severity of drug-induced liver injury

Scientific Reports, 2023
We investigated the relationship between dyslipidemia and drug-induced liver injury (DILI), especially the level of triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) in severe DILI.
Xiaoqing Jia, Xiaoting Zhang, Ming Yan, Dalong Sun, Rong Li, Na Yang, Zheng Luo   +6 more
doaj   +1 more source

Tide level in time and frequency domains at Dili port: Characteristic feature of a Lorentz oscillator

Physics of Complex Systems, 2021
Tide level during one year in time-domain measured at Dili port (East Timor) is analyzed by the frequency spectrum with the Fast Fourier Transform (FFT), together with the autocorrelation function (AF).
Abelito Filipe Belo, Kenji Sasa, Jose Madeira Marques, Koichi Shimakawa   +3 more
doaj   +1 more source

A Computational Toxicology Approach to Screen the Hepatotoxic Ingredients in Traditional Chinese Medicines: Polygonum multiflorum Thunb as a Case Study

Biomolecules, 2019
In recent years, liver injury induced by Traditional Chinese Medicines (TCMs) has gained increasing attention worldwide. Assessing the hepatotoxicity of compounds in TCMs is essential and inevitable for both doctors and regulatory agencies.
Shuaibing He, Xuelian Zhang, Shan Lu, Ting Zhu, Guibo Sun, Xiaobo Sun   +5 more
doaj   +1 more source

Monograf: Edebiyat Eleştirisi Dergisi Üzerine Söyleşi: Monograf Dergiciliğin Akışkanlığını, Akademininse Kamusallığını Hatırlattı

Nesir: Edebiyat Araştırmaları Dergisi, 2022
Türkiye’deki edebi üretimi disiplinlerarası bir bakışla değerlendiren edebiyat çalışmalarına yer veren Monograf, 2014’ten 2022’ye kapsamlı bir eleştirel birikim oluşturdu.
Esra Nur Akbulak, Kaan Kurt
doaj   +1 more source