Results 41 to 50 of about 107,502 (231)

Multimodal Multiorgan‐on‐a‐Chip Platform for Probing Liver‐Tumor Interactions and Advancing Prodrug Screening

Advanced Science, EarlyView.
This work introduces a multimodal multi‐OoC platform that overcomes current limitations in liver‐tumor interaction studies and prodrug screening. By integrating dynamic microfluidic circuits, electrochemical sensing, and mass analysis, this platform enables non‐invasive, longitudinal monitoring of drug metabolism and hepatotoxicity, offering a ...
Dan Wang, Yisong Huang, Weijian Zhao, Tian Chen, Siyu Bai, Denghui Guo, Mengying Wang, Yaoyao Zhao, Liang Zhao, Guangsheng Guo, Xiayan Wang   +10 more
wiley   +1 more source

Urine metabolomics and microbiome analyses reveal the mechanism of anti-tuberculosis drug-induced liver injury, as assessed for causality using the updated RUCAM: A prospective study

Frontiers in Immunology, 2022
BackgroundAnti-tuberculosis drug-induced liver injury (ATB-DILI) is one of the most common adverse reactions that brings great difficulties to the treatment of tuberculosis. Thus, early identification of individuals at risk for ATB-DILI is urgent.
Ming-Gui Wang, Ming-Gui Wang, Shou-Quan Wu, Meng-Meng Zhang, Jian-Qing He   +4 more
doaj   +1 more source

The promise and peril of paralegal aid [PDF]

, 2018
Strengthening the rule of law and promoting access to justice in developing countries have been longstanding international policy objectives. However, the standard policy tools, such as technical assistance and material aid, are routinely criticized for ...
Swenson, G.
core   +2 more sources

Increased Risk of Intrahepatic Cholestasis of Pregnancy in SLE Women Exposed to Azathioprine

Arthritis &Rheumatology, Accepted Article.
Objectives To evaluate the risk of intrahepatic cholestasis of pregnancy (ICP) in azathioprine (AZA)‐exposed versus unexposed SLE pregnancies within the multi‐centre prospective Lupus in prEGnAnCY (LEGACY) cohort. Methods LEGACY is conducted at Systemic Lupus International Collaborating Centres in Canada, South Korea, Peru, and Mexico.
Reem Farhat, Maria del Carmen Zamora‐Medina, Sang‐Cheol Bae, Megan R.W. Barber, Ann E. Clarke, Paul R. Fortin, Zahi Touma, Carl A. Laskin, Isabelle Malhamé, Giada Sebastiani, Christine Peschken, Manuel F. Ugarte‐Gil, Alexandra Legge, Sasha Bernatsky, Évelyne Vinet   +14 more
wiley   +1 more source

Management of drug-induced liver injury in people with HIV treated for tuberculosis: 2024 update

Southern African Journal of HIV Medicine
No abstract available.
Tom Boyles, Rebecca H. Berhanu, Neliswa Gogela, Hannah Gunter, Tamsin Lovelock, Ndiviwe Mphothulo, Arifa Parker, Helena Rabie, Lauren Richards, Phumla Sinxadi, Camilla Wattrus, Mahomed-Yunus Moosa   +11 more
doaj   +1 more source

Combined analysis of 16S rDNA sequencing and metabolomics to find biomarkers of drug-induced liver injury

Scientific Reports, 2023
Drug induced liver injury (DILI) is a kind of liver dysfunction which caused by drugs, and gut microbiota could affect liver injury. However, the relationship between gut microbiota and its metabolites in DILI patients is not clear.
Kaini He, Mimi Liu, Qian Wang, Sijie Chen, Xiaoyan Guo   +4 more
doaj   +1 more source

Monograf: Edebiyat Eleştirisi Dergisi Üzerine Söyleşi: Monograf Dergiciliğin Akışkanlığını, Akademininse Kamusallığını Hatırlattı

Nesir: Edebiyat Araştırmaları Dergisi, 2022
Türkiye’deki edebi üretimi disiplinlerarası bir bakışla değerlendiren edebiyat çalışmalarına yer veren Monograf, 2014’ten 2022’ye kapsamlı bir eleştirel birikim oluşturdu.
Esra Nur Akbulak, Kaan Kurt
doaj   +1 more source

Kur'an'da Benzetmelerin Dili

Journal of Turkish Studies, 2018
Bu makale, yüce Allah’ın Kur’ân-ı Kerîm’de dinî emirleri, olayları ve ilgili ortamlarda yer alan insanların tutum ve davranışlarını anlatırken yer verdiği benzetmelerin ifade ettiği hakikatler üzerinde duracaktır. Kur’an’da dinî emirler, olaylar ve davranış biçimleri üzerinden ifade edilen hakikatlerin anlaşılmasında benzetmelerin anlama katkısı, dil ...
openaire   +3 more sources

Relationship Between Characteristics of Medications and Drug-Induced Liver Disease Phenotype and Outcome [PDF]

, 2014
Background & Aims: It is not known if specific characteristics of medication are associated with type of drug-induced liver injury (DILI) or outcome.
Chalasani, Naga, Fontana, Robert J., Ghabril, Marwan, Gotur, Raghavender, Gu, Jiezhun, Kosinski, Andrzej S., Reddy, K. Rajender, Serrano, Jose, Vuppalanchi, Raj   +8 more
core   +1 more source

Genetic and Immune Predictors for Hypersensitivity Syndrome to Antiepileptic Drugs [PDF]

, 2011
Hypersensitivity syndrome reactions (HSR) to antiepileptic drugs (AED) are associated with severe clinical cutaneous adverse reactions (SCAR).Our aims are: to assess HSRs to AEDs using the in vitro lymphocyte toxicity assay (LTA) in patients who ...
Lawrence Cohen, Manuela G. Neuman, Paul A. Hwang, Radu M. Nanau   +3 more
core   +1 more source