Results 41 to 50 of about 14,328 (204)

Re‐evaluating variability of circulating miR‐122 in healthy volunteers: Implications for biomarker qualification in drug‐induced liver injury

British Journal of Clinical Pharmacology, EarlyView.
Drug‐induced liver injury (DILI) remains a major challenge in clinical practice and drug development, and reliable biomarkers are still needed. MicroRNA‐122 (miR‐122) has shown promise, but reported inter‐individual variability in healthy populations has raised concerns about its clinical utility.
Irum Javid, Giusy Russomanno, Anthony Evans, Guruprasad P. Aithal, Shiva S. Forootan, Warren E. Glaab, Matthias Hackl, Joely Irlam, Kseniya Khamina‐Kotisch, Samantha Korver, Gerd A. Kullak‐Ublick, Sophia L. Samodelov, Christopher E. Goldring   +12 more
wiley   +1 more source

Advanced In Vitro Platforms for Experimental Liver Research: From Organoids and Liver‐on‐Chip to Omics and Artificial Intelligence

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Hepatocytes perform essential physiological functions in the human body. Gaining more profound insight into the liver structure, diseases, and physiology by using in vitro models can help to propose more relevant clinical applications. Conventional in vitro liver models, such as two‐dimensional (2D) cell cultures, fail to adequately replicate ...
Seyedeh Kiana Teymorian, Pedram Asadi Sarabi, Abbas Piryaei, Massoud Vosough   +3 more
wiley   +1 more source

Click Bioconjugation of Aza‐BODIPY Fluorophores to LfcinB Peptides for Improved Biocompatibility

European Journal of Organic Chemistry, EarlyView.
Click bioconjugation attaches NIR aza‐BODIPY fluorophores to LfcinB‐derived anticancer peptides via CuAAC and thiol‐maleimide chemistry. Conjugates exhibit improved predicted solubility while retaining strong NIR absorption (703–730 nm). Peptide‐aza‐BODIPY conjugates induce apoptotic morphology in HeLa cancer cells.
A. Verónica Rodríguez‐Mayor, Maricela Morales, Héctor Manuel Pineda‐Castañeda, Zuly Jenny Rivera‐Monroy, Javier Eduardo García‐Castañeda, Norberto Farfán, Rosa Santillan   +6 more
wiley   +1 more source

Drug-Induced Liver Injury During Treatment With Tocilizumab: A Case Report of an Atypical Pattern Lesion. [PDF]

Pharmacol Res Perspect
ABSTRACT Tocilizumab is an interleukin‐6 (IL‐6) receptor antagonist indicated for various rheumatologic conditions. While hepatotoxicity is a recognized adverse effect, it predominantly manifests as hepatocellular injury. We report a rare case of drug‐induced liver injury (DILI) presenting with a cholestatic pattern and cholangitis features in a 75 ...
Barbaro LE, Ben Othman N, Viard D, Rocher F, Ewig E, Mroue R, Amigues C, Gérard AO.   +7 more
europepmc   +2 more sources

Hepatic macrophages in drug-induced liver injury

Liver Research, 2019
Drug-induced liver injury (DILI) is a major public health concern. Intrinsic DILI, for example, acetaminophen overdose accounts for half of acute liver failure in the United States.
Zhao Shan, Cynthia Ju
doaj   +1 more source

Lessons Learnt Delivering a Novel Infectious Diseases National Training Programme to Timor-Leste’s Primary Care Workforce

Annals of Global Health
Background and Objectives: Timor-Leste is a lower-middle-income country in Southeast Asia. To control the significant local threat from infectious diseases, it is imperative to strengthen the knowledge and practice capabilities of the primary care ...
Robert Hammond, Antonito Hornay Cabral, Jeremy Beckett, Xhian Meng Quah, Natarajan Rajaraman, Sanjay Mathew, Amrutha Gopalakrishnan, Mariano Pereira, Manuel Natercio Noronha, Bernardo Pinto, João de Jesus Arcanjo, Celia Gusmao dos Santos, Telma Joana Corte-Real de Oliveira, Ingrid Bucens, Charlotte Hall   +14 more
doaj   +1 more source

The Influence of Regional Government and Community Participation on the Development of Spiritual Tourism in Pante Makasar, Timor-Leste

International Journal of Home Economics, Hospitality and Allied Research
This study examines the role of government and community participation in the development of spiritual tourism in Pante Makassar, Oe-Cusse Municipality, Timor-Leste.
Cevat Tosun, Jacinto Colo, Helio Brites da Silva   +2 more
doaj   +1 more source

Polydatin Alleviates APAP‐Induced Hepatotoxicity by Targeting C/EBPβ to Suppress the NLRP3 Inflammasome Signaling Pathway

iNew Medicine, EarlyView.
PD alleviates APAP‐induced ALI by inhibiting the NLRP3 inflammasome signaling pathway. C/EBPβ is identified as a direct target via multimethod validation. PD promotes the deacetylation of C/EBPβ via Sirt1. The Sirt1/C/EBPβ/NLRP3 signaling axis is defined for PD's hepatoprotective effect.
Tian‐Yu Yang, Chen Wang, Yi Ding, Wei‐Kang Zhang, Ling Zheng, Li Yue, Lei Zhang   +6 more
wiley   +1 more source

Antimicrobial susceptibility of priority bacterial pathogens from laboratory samples in Timor-Leste: a retrospective analysis of database (2020–2025)

The Lancet Regional Health - Southeast Asia
Summary: Background: Antimicrobial resistance (AMR) is a major global health threat, with the highest burden in low-income and middle-income countries where diagnostic and surveillance capacity are often limited.
Tessa Oakley, Carolina da Costa Maia, Celita Osorio do Rosario, Messias Soares, Joana Correia Belo, Virginia da Conceição, Névio Sarmento, Lucia Toto, Elfiana Amaral, Domingas da Costa Campos, Raikos Allan, Karen Champlin, Endang Soares da Silva, Ari Jayanti Pereira Tilman, Helio Guterres, Lucsendar Alves, Anthony DK. Draper, Benjamin F.R. Dickson, Ian Marr, Jennifer Yan, Heidi Smith-Vaughan, Joshua R. Francis   +21 more
doaj   +1 more source

Combined analysis of 16S rDNA sequencing and metabolomics to find biomarkers of drug-induced liver injury

Scientific Reports, 2023
Drug induced liver injury (DILI) is a kind of liver dysfunction which caused by drugs, and gut microbiota could affect liver injury. However, the relationship between gut microbiota and its metabolites in DILI patients is not clear.
Kaini He, Mimi Liu, Qian Wang, Sijie Chen, Xiaoyan Guo   +4 more
doaj   +1 more source