Results 61 to 70 of about 13,535 (197)

Liver Organoids: From Disease Modelling to Regenerative Medicine

Cell Proliferation, EarlyView.
Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang, Xiaotian Qu, Jinhong Si, Junkang Meng, Ting Zhang, Shuliang Niu   +5 more
wiley   +1 more source

Rare Variants in PFIC‐Related Genes Among Adults With Intrahepatic Cholestasis

Hepatology Research, EarlyView.
ABSTRACT Aim Biallelic pathogenic variants in progressive familial intrahepatic cholestasis (PFIC)‐related genes cause severe pediatric cholestasis. However, the clinical significance of heterozygous variants in adult intrahepatic cholestasis remains unclear.
Shunji Hirose, Kota Tsuruya, Yusuke Mishima, Yoshitaka Arase, Koichi Shiraishi, Vu Thi Hao, Satsuki Ieda, Masayuki Tanaka, Sanae Isaki, Tatehiro Kagawa   +9 more
wiley   +1 more source

Drug-Induced Liver Injuries (Clinical Guidelines for Physicians)

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2019
Aim. Clinical guidelines for the management of adult patients suffering from drug-induced liver injuries (DILI) are intended for all medical specialists, who treat such patients in their clinical practice.Key findings.
Vladimir T. Ivashkin, Andrey Yu. Baranovsky, Karina L. Raikhelson, Lyudmila K. Palgova, Marina V. Maevskaya, Elina A. Kondrashina, Natalya V. Marchenko, Tatyana P. Nekrasova, Igor G. Nikitin   +8 more
doaj   +1 more source

Generative Artificial Intelligence as a Linguistic Crutch or Cognitive Scaffold: The Interplay of Self‐Beliefs and General English Proficiency in English Medium Instruction

International Journal of Applied Linguistics, EarlyView.
ABSTRACT This study examines how self‐efficacy, self‐regulation, and generative artificial intelligence (GenAI) ‐related factors interact to shape academic success and general English proficiency (GEP) within an EMI context. It draws on data from 754 EMI students at a major public university in Turkey, focusing on the social sciences and engineering ...
Mehmet Barış Horzum, Adem Soruç, Dogan Yuksel, Mirosław Pawlak   +3 more
wiley   +1 more source

Validation of an UHPLC–MS/MS Assay for the Quantification of Isoniazid and Four Major Metabolites in Human Plasma

Biomedical Chromatography, Volume 40, Issue 9, September 2026.
ABSTRACT Isoniazid (INH) is a key component of tuberculosis treatment regimens but is also associated with hepatotoxicity. This toxicity is mediated in part by its metabolites, but some degrade rapidly in plasma. A rapid freeze/thaw process with a methanol protein precipitation extraction was developed to slow the rapid degradation of acetylisoniazid ...
David Nerguizian, Brandon Klein, Farah Abdelmawla, Joe Gomez, Peter L. Anderson, Lane Bushman, Kristina M. Brooks   +6 more
wiley   +1 more source

Review of Pulmonary Sarcoidosis Progress into a Refractory Disease: Risk Factors, Biomarkers and Imaging as the Evaluation

Jurnal Respirasi
Sarcoidosis is a multisystem, immune-mediated disorder of undetermined etiology, characterized by the formation of non-caseating granulomas. Pulmonary sarcoidosis exhibits highly variable clinical progression.
Amalia Margaretha Lucas, Antonio Ayrton Widiastara, João Carlos Lopes, Fabiola Idinha Gama da Costa Lobo   +3 more
doaj   +1 more source

Hepatic Safety of Orforglipron in Adults With Obesity or Overweight and/or Type 2 Diabetes: A Pooled Analysis of the Orforglipron Phase 3 Clinical Trials

Diabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 8347-8358, September 2026.
ABSTRACT Aims Orforglipron is a novel small‐molecule, once daily oral non‐peptide GLP‐1 receptor agonist. The hepatic safety profile in adults with obesity or overweight and/or type 2 diabetes (T2D) across seven orforglipron Phase 3 clinical trials was assessed.
Sean Wharton, Adam Stefanski, Jiaxun Chen, Girish Rao, Elvis Asare Twum, Max Denning   +5 more
wiley   +1 more source

Selected ABCB1, ABCB4 and ABCC2 polymorphisms do not enhance the risk of drug-induced hepatotoxicity in a Spanish cohort.

PLoS ONE, 2014
Background and aimsFlawed ABC transporter functions may contribute to increased risk of drug-induced liver injury (DILI). We aimed to analyse the influence of genetic variations in ABC transporters on the risk of DILI development and clinical ...
Eugenia Ulzurrun, Camilla Stephens, Francisco Ruiz-Cabello, Mercedes Robles-Diaz, Pablo Saenz-López, Hacibe Hallal, German Soriano, Eva Roman, M Carmen Fernandez, M Isabel Lucena, Raúl J Andrade   +10 more
doaj   +1 more source

Rational Design of Multifunctional Tacrine Derivatives as Candidates for the Treatment of Alzheimer and Parkinson Diseases

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
We present a set of multifunctional tacrine derivatives, designed with the CADMA‐Chem protocol, aimed for Alzheimer and Parkinson diseases. Of the tacrines designed, TAC‐674 and TAC‐678 are the best candidates to act as multifunctional antioxidants and neuroprotectors for Alzheimer and Parkinson diseases, respectively.
Eugenia Dzib, Luis Felipe Hernández‐Ayala, Silvana Silva‐Aguirre, Annia Galano   +3 more
wiley   +1 more source

Adverse events in bedaquiline‐ and pretomanid‐based regimens for drug‐resistant tuberculosis from trial, implementation and pharmacovigilance studies

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2607-2623, August 2026.
Abstract The availability of safety data, particularly concerning adverse events (AEs) associated with the new shorter regimen for drug‐resistant tuberculosis (TB) containing a bedaquiline–pretomanid‐based regimen, is still limited. This systematic review aims to provide a comprehensive and updated analysis of AEs related to this new regimen by ...
Nisa Maria, Annisa Lazuardi Larasati, Indri Yuliani Hamdani, Jin‐Gun Cho, Jan‐Willem C. Alffenaar   +4 more
wiley   +1 more source