Results 71 to 80 of about 14,328 (204)

The return of the Bee Sultan: Vibrant encounters of environmentalism and language reclamation in Turkey's Hemshin lands

Journal of Linguistic Anthropology, Volume 36, Issue 3, December 2026.
Abstract This article examines how language and environment become constitutive through the emergent environmentalism of Hemshin youth returning to Turkey's Hemshin lands from major cities. As development transforms the landscape, young Hemshins engage in “reading” their lands, encountering linguistic and material traces like stories, place names, and ...
Neşe Kaya‐Özkan
wiley   +1 more source

Selected ABCB1, ABCB4 and ABCC2 polymorphisms do not enhance the risk of drug-induced hepatotoxicity in a Spanish cohort.

PLoS ONE, 2014
Background and aimsFlawed ABC transporter functions may contribute to increased risk of drug-induced liver injury (DILI). We aimed to analyse the influence of genetic variations in ABC transporters on the risk of DILI development and clinical ...
Eugenia Ulzurrun, Camilla Stephens, Francisco Ruiz-Cabello, Mercedes Robles-Diaz, Pablo Saenz-López, Hacibe Hallal, German Soriano, Eva Roman, M Carmen Fernandez, M Isabel Lucena, Raúl J Andrade   +10 more
doaj   +1 more source

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1326-1337, November 2026.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries, Alastair M. Kilpatrick, Kathleen M. Scullion, Rhona Aird, Lorraine Bruce, Maria Elena Candela, Tak Yung Man, Stuart J. Forbes, James W. Dear   +8 more
wiley   +1 more source

Review of Pulmonary Sarcoidosis Progress into a Refractory Disease: Risk Factors, Biomarkers and Imaging as the Evaluation

Jurnal Respirasi
Sarcoidosis is a multisystem, immune-mediated disorder of undetermined etiology, characterized by the formation of non-caseating granulomas. Pulmonary sarcoidosis exhibits highly variable clinical progression.
Amalia Margaretha Lucas, Antonio Ayrton Widiastara, João Carlos Lopes, Fabiola Idinha Gama da Costa Lobo   +3 more
doaj   +1 more source

Quantitative Systems Toxicology Model Predicts Obeticholic Acid‐Associated Liver Injury in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1358-1367, November 2026.
Obeticholic acid (OCA), a synthetic analog of chenodeoxycholic acid, was approved in 2016 for the treatment of primary biliary cholangitis. Early clinical trials revealed elevated liver biomarkers in healthy subjects receiving supratherapeutic OCA doses (100–250 mg).
Abigail K. Mayo, James J. Beaudoin, Jeffrey L. Woodhead, Paul B. Watkins, Kim L. R. Brouwer   +4 more
wiley   +1 more source

In Silico Clinical Trials in Drug Development: Virtual Patients, Applications, and Regulatory Convergence

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1181-1194, November 2026.
Conventional clinical trials remain the benchmark for evaluating therapeutic safety and efficacy, yet they are constrained by escalating costs, withdrawal over the extended follow‐up periods, recruitment difficulties, ethical limits, and a restricted ability to characterize heterogeneous populations.
Maximilian Balmus, Sheng‐Ya Wang, Edward W. G. Ashton, Rosie K. Barrows, Molly Monks, Yuzhang Ge, Arthur Lefebvre, Steven A. Niederer   +7 more
wiley   +1 more source

A Phase 1 Study of MK‐1942, a Negative Allosteric Modulator of mGluR2, in Healthy Japanese to Flexibly Assess Factors Including CYP2C19 Phenotype

Clinical and Translational Science, Volume 19, Issue 11, November 2026.
ABSTRACT MK‐1942 is a negative allosteric modulator of the metabotropic glutamate receptor 2 that was investigated for the treatment of Alzheimer's disease and depression. Nonclinical studies with recombinant human CYPs and genotyped human hepatocytes suggested that CYP2C19 is involved in the metabolism of MK‐1942. Given the high incidence of different
Chihiro Hasegawa, Yohei Doi, Tomona Hirano, Masayoshi Shirakawa, Saori Tsuchiya, Hiroyuki Yoshitsugu, Kenichi Furihata, Callie Miller, Sonal Singh, Tamara Cabalu, Ka Lai Yee, Tjerk Bueters, Zoi Alexopoulou   +12 more
wiley   +1 more source

Diethylene Glycol‐Linked Ring‐Fused Bis‐Azoles: Target‐Oriented Synthesis, In Silico Screening, and Antitumor Activity

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A series of diethylene glycol‐linked cyclic derivatives with diversity in the heterocyclic motif have been synthesized and screened for antitumor activity. Two bis‐thiazolo[3,2‐a]pyrimidinone derivatives displayed moderate cytotoxicity, high selectivity against hepatocellular carcinoma cells, promising VEGFR2, and remarkable FGFR2 inhibitory activities
Sami A. Al‐Hussain, Abdulrahman S. Alharbi, Zeinab A. Muhammad, Alyaa S. Abdel Halim, Magdi E. A. Zaki, Mark C. Bagley, Refaie M. Kassab   +6 more
wiley   +1 more source

National cross-sectional cluster survey of tuberculosis prevalence in Timor-Leste: a study protocol

BMJ Open
Introduction Timor-Leste has one of the world’s highest estimated tuberculosis (TB) incidences, yet the data which informs this estimate is limited and the true burden of TB disease is not known.
Joana Dias, Joshua Reginald Francis, Jennifer Yan, Christopher Lowbridge, Nelson Martins, Salvador Amaral, Tessa Oakley, Nevio Sarmento, Endang da Silva, Constantino Lopes, Josefina Clarinha Joao, Rofina Isabel Gusmão dos Santos, Sureshbabu Ramalingam, Lourenco da Costa Ico   +13 more
doaj   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source