Results 91 to 100 of about 107,502 (231)

PENERAPAN STRATEGI PARTISIPATIF DENGAN MEDIA BLOG DALAM PEMBELAJARAN MENULIS CERPEN: penelitian eksperimen kuasi pada siswa Kelas VII SMP Negeri 16 Bandung Tahun Ajaran 2014/2015 [PDF]

open access: yes, 2015
Penelitian ini dilatarbelakangi oleh rendahnya minat siswa dalam pembelajaran menulis cerpen di sekolah. Berdasarkan hal tersebut, peneliti menguji penerapan strategi partisipatif dengan media blog dalam pembelajaran menulis cerpen di kelas VII ...
Pradana, Bryan Dika Jefri Dili
core  

Hepatotoxicity by Drugs: The Most Common Implicated Agents. [PDF]

open access: yes, 2016
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.Idiosyncratic drug-induced liver injury (DILI) is
Björnsson, Einar S
core   +2 more sources

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

open access: yesAdvanced Science, Volume 13, Issue 20, 9 April 2026.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang   +16 more
wiley   +1 more source

Quantitative Systems Toxicology Modeling with DILIsym to Support Phase 3 Dose Selection for Fezolinetant

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 1016-1024, April 2026.
Fezolinetant is a first‐in‐class, selective, non‐hormonal, neurokinin 3 receptor antagonist that is approved for the treatment of moderate to severe vasomotor symptoms due to menopause. In a phase 2b clinical study (n = 352), nine study participants experienced elevations in serum transaminases exceeding three times the upper limit of normal.
Jace C. Nielsen   +11 more
wiley   +1 more source

National cross-sectional cluster survey of tuberculosis prevalence in Timor-Leste: a study protocol

open access: yesBMJ Open
Introduction Timor-Leste has one of the world’s highest estimated tuberculosis (TB) incidences, yet the data which informs this estimate is limited and the true burden of TB disease is not known.
Joana Dias   +13 more
doaj   +1 more source

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity. [PDF]

open access: yes, 2017
Assessing the potential of a new drug to cause drug-induced liver injury (DILI) is a challenge for the pharmaceutical industry. We therefore determined whether cell models currently used in safety assessment (HepG2, HepaRG, Upcyte and primary human ...
Aerts, H   +22 more
core   +1 more source

Üniversitelerdeki Türk Dili Derslerinin Dünü, Bugünü, Yarını (Sorunlar-Çözüm Önerileri) Çalıştayı

open access: yesSkad, 2023
Bu yazı Sakarya Üniversitesi Rektörlük-Türk Dili Bölümü tarafından 26 Eylül 2023 tarihinde yapılan "Üniversitelerdeki Türk Dili derslerinin Dünü, Bugünü, Yarını (Sorunlar-Çözüm Önerileri)" adlı çalıştayı konu almaktadır.
Hürdünya Şahan, Özlem Düzlü
doaj  

The "empty shell" approach: the setup process of international administrations in Timor-Leste and Kosovo, its consequences and lessons [PDF]

open access: yes, 2011
State-building under the aegis of international administrations has faced various hurdles and obstacles in Kosovo and Timor-Leste — failures that came to full light in March 2004 in Kosovo and in May 2006 in Timor-Leste.
Lemay-Hebert, Nicolas
core   +1 more source

Drug-Induced Liver Injuries (Clinical Guidelines for Physicians)

open access: yesРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии, 2019
Aim. Clinical guidelines for the management of adult patients suffering from drug-induced liver injuries (DILI) are intended for all medical specialists, who treat such patients in their clinical practice.Key findings.
Vladimir T. Ivashkin   +8 more
doaj   +1 more source

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