Results 81 to 90 of about 14,328 (204)

InterDILI: interpretable prediction of drug-induced liver injury through permutation feature importance and attention mechanism

Journal of Cheminformatics
Safety is one of the important factors constraining the distribution of clinical drugs on the market. Drug-induced liver injury (DILI) is the leading cause of safety problems produced by drug side effects.
Soyeon Lee, Sunyong Yoo
doaj   +1 more source

A Review of Detection Probes for Vanin‐1: Development and Biological Applications in Various Inflammatory Diseases

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Vanin has emerged as a diagnostic biomarker for inflammation‐related diseases. Vanin‐1 probes have seen continuous improvements in sensitivity, selectivity, and practicality, evolving from fluorescent probes to bioluminescent probes, chemiluminescent probes, and electrochemical probes.
Shumei Wang, Xing Li
wiley   +1 more source

Low Phospholipid‐Associated Cholelithiasis in a Mother–Son Pair Associated With a Novel ABCB4 Frameshift Variant

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Low phospholipid‐associated cholelithiasis (LPAC) syndrome is a rare inherited disorder caused by ABCB4 mutations with heterogeneous manifestations. We describe two LPAC cases in a mother–son pair, detailing their clinical presentations, diagnostic evaluations, and management. A novel ABCB4 frameshift variant (c.715_716insTT; p.Ser239PhefsTer9)
Hui‐Ming Yang, Jun Liu, Zheng Zhang
wiley   +1 more source

Gut microbiota causally affects drug-induced liver injury via plasma metabolites: a Mendelian randomization study

Frontiers in Microbiology
BackgroundThe gut microbiota and plasma metabolites play important roles in the progression of drug-induced liver injury (DILI). We investigated the causal associations between the gut microbiota, plasma metabolome, and DILI.MethodsThe summary data for ...
Haoshuang Fu, Shuang Zhao, Shuying Song, Qing Xie   +3 more
doaj   +1 more source

Plant Part–Specific Differences in Ashwagandha (Withania somnifera): A Comparative Evaluation of Root and Leaf Evidence for Safety and Regulation

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
This review contrasts the root and leaf of Withania somnifera (ashwagandha) across phytochemistry, clinical evidence, and regulatory context. Root preparations are dominated by withanolide A, D, and glyco‐withanolides, with multiple randomized controlled trials supporting reductions in stress, anxiety, and insomnia alongside a favorable safety profile.
Abhijit Dutta, Jang Bahadur Gupta
wiley   +1 more source

Dilin Dili ve Şiirin Dili

, 2014
[No Abstract Available]
openaire   +2 more sources

Chlorine Position Governs the Multitarget Bioactivity of Phenylhydrazines: In Vitro Antioxidant, Anti‐Inflammatory, Anti‐Tyrosinase and Antibacterial Evaluation Supported by DFT and Molecular Docking

ChemistrySelect, Volume 11, Issue 37, 6 October 2026.
Positional chlorination emerges as a key determinant of multitarget activity in phenylhydrazines. The para‐chloro derivative H3 shows the strongest anti‐inflammatory response, notable antibacterial activity, favorable ADMET behavior, and high COX‐2 affinity. DFT descriptors and molecular docking rationalize these substitution‐dependent effects, linking
L. Aouachria, S. Issadi, H. Debab, I. Selatnia, A.G. Soliman, K. Metwally, O. M. A. Khamaysa, Han‐seung Lee, Hassane Lgaz   +8 more
wiley   +1 more source

Coumarin‐Benzimidazole Hybrids as Multitarget Scaffolds for Antileishmanial Drug Discovery

ChemistrySelect, Volume 11, Issue 38, 13 October 2026.
Coumarin‐benzimidazole hybrids emerge as promising antileishmanial agents through virtual screening against essential Leishmania enzymes, Cathepsin B (CatB), and N‐myristoyltransferase (NMT). Molecular docking and dynamics simulations reveal highly stable target interactions that surpass the reference drug miltefosine (MTF).
Fernanda Melo Jucá, Damião Sampaio de Sousa, Caio Henrique Alexandre Roberto, Márcia Machado Marinho, Emmanuel Silva Marinho   +4 more
wiley   +1 more source

Gut microbiota and metabolomic profiles of tacrolimus-induced DILI in renal transplant recipients: a population-based case control study

BMC Microbiology
Background In clinical practice, cases of drug-induced liver injury (DILI) often occur in renal transplant recipients treated with tacrolimus (Tac) as an immunosuppressive therapy.
Guolin Li, Yifu Hou, Lijuan Zhang, Lu Chen, Yong Yang, Dongke Yu   +5 more
doaj   +1 more source

Metronidazole and Eugenol Hybrids as an Alternative Against Multidrug‐Resistant Bacteria

ChemistrySelect, Volume 11, Issue 39, 20 October 2026.
Structures of the synthesized hybrid compounds AC1–AC8. Figure adapted from Pelozo et al. ABSTRACT Antibiotic resistance is a global threat to human and animal health, since several bacterial species have developed different forms of resistance. Therefore, it is essential to seek effective methods to combat bacterial resistance. Research indicates that
João Arthur de Oliveira Borges, Lucas dos Santos Sa, Francisco Ruan Moreira da Silva Santos, Cicera Laura Roque Paulo, Raimundo Luiz Silva Pereira, Daniel Sampaio Alves, Ana Carolina Justino de Araújo, Francisco Nascimento Pereira Junior, Ana Laura Marques Trinca, Douglas Henriques Novais Junior, Lucas Lopardi Franco, Janaína Esmeraldo Rocha, Henrique Douglas Melo Coutinho, Maria Karollyna do Nascimento Silva Leandro   +13 more
wiley   +1 more source