Results 51 to 60 of about 14,328 (204)

Impact of cystic fibrosis transmembrane conductance regulator modulator therapies on liver stiffness and liver enzymes: An observational perspective single‐center cohort study

JPGN Reports, EarlyView.
Abstract Objectives The efficacy of cystic fibrosis transmembrane conductance regulator (CFTR)‐modulator therapies in preventing or ameliorating cystic fibrosis liver disease (CFLD) by correcting CFTR in cholangiocytes is not well‐documented. This study aimed to assess liver function during CFTR‐modulators.
Laura Giugliano, Elisabetta Augustoni, Antonio Pizzol, Anna Opramolla, Cristina Chiadò, Anna Zagaria, Irene Esposito, Giulia Roberto, Alice Ponte, Andrea Evangelista, Paola Quarello, Michele Pinon, Pier Luigi Calvo   +12 more
wiley   +1 more source

Hepatocyte DDX3X protects against drug-induced acute liver injury via controlling stress granule formation and oxidative stress

Cell Death and Disease, 2023
Drug-induced liver injury (DILI) is the leading cause of acute liver failure (ALF). Continuous and prolonged hepatic cellular oxidative stress and liver inflammatory stimuli are key signatures of DILI.
Tingting Luo, Suzhen Yang, Tianming Zhao, Hanlong Zhu, Chunyan Chen, Xiaoxiao Shi, Di Chen, Kai Wang, Kang Jiang, Dan Xu, Ming Cheng, Juan Li, Wenting Li, Weijun Xu, Lin Zhou, Mingzuo Jiang, Bing Xu   +16 more
doaj   +1 more source

Determinants of Early Renal Function Recovery After TIPS in Patients With Portal Hypertension

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Renal dysfunction frequently occurs in patients with portal hypertension and is linked to unfavorable clinical outcomes. Transjugular intrahepatic portosystemic shunt (TIPS) has the potential to enhance renal perfusion through portal decompression; however, factors predicting early improvement in renal function remain insufficiently defined ...
Meng Jia, Yang Luo, Zhao‐Yang Tan, Xiao‐Ling Zhou, Xi‐You Zhang, Jing‐Ying Sun, Ye Du   +6 more
wiley   +1 more source

Morphological evolution of colonial space in island cities: a case study in the Dili City, Timor-Leste

Journal of Asian Architecture and Building Engineering
Island cities’ spatial form shapes their unique land-sea integrated development model and profoundly influences urban functional layout, resource utilization, and cultural inheritance, with Dili serving as a typical case of colonial planning-influenced ...
Yile Chen, Qingnian Deng, Jingwei Liang, Yuhao Huang, Liang Zheng, Jiaying Fang   +5 more
doaj   +1 more source

Dili

, 2021
Dissertação de Mestrado em Arquitetura com a especialização em Arquitetura apresentada na Faculdade de Arquitetura da Universidade de Lisboa para obtenção do grau de Mestre.
openaire   +1 more source

AI‐enabled engineering of hesperidin/ursodeoxycholic acid nanomedicine for synergistic treatment of drug‐induced liver injury

Smart Molecules, EarlyView.
An AI‐driven framework integrating disease‐network analysis, direction‐aware molecular screening, and carrier‐free co‐assembly engineering enables nanomedicine design. The dual‐constraint deep learning model predicts API–target affinity and regulatory direction to prioritize complementary APIs.
Kai Xiao, Meng Fan, Haoyu Zheng, Boyuan Gu, Shaowen Wang, Ziping Wu, Shiming Zhang, Xin Zhao, Wensheng Zhang, Quanxin Ning, Sigen A, Chao Yang, Huayi Sun, Ren Mo, Dan Shao   +14 more
wiley   +1 more source

Development of Prediction Models for Drug-Induced Cholestasis, Cirrhosis, Hepatitis, and Steatosis Based on Drug and Drug Metabolite Structures

Frontiers in Pharmacology, 2020
Drug-induced liver injury (DILI) is one of the major reasons for termination of drug development. Due to the importance of predicting DILI in early phases of drug development, diverse in silico models have been developed to filter out DILI-causing ...
Hyun Kil Shin, Myung-Gyun Kang, Daeui Park, Daeui Park, Tamina Park, Tamina Park, Seokjoo Yoon, Seokjoo Yoon   +7 more
doaj   +1 more source

Hunting in the Ghaznavid State: Courtly Culture, Military Practices and Political Power

History, EarlyView.
Abstract Hunting occupied an important place in the royal court culture of the Ghaznavid state (963–1186 CE). Ghaznavid hunting culture developed through the interaction of Turkic‐Islamic political traditions, Persianate models of kingship and local ecological settings. Rather than constituting a fully formalized institution, Ghaznavid hunting practice
Arslan Durdu
wiley   +1 more source

Multi-Stakeholder Engagement in Community-Based Tourism Development: Evidence from Pante Makassar, Timor-Leste

International Journal of Home Economics, Hospitality and Allied Research
This study examined the stakeholders' engagement in Community-Based Tourism (CBT) in Pante Makassar, Oe-Cusse, Timor-Leste. The stakeholders included the local community, the private sector, tourists, and the local government.
Cevat Tosun, Nicolao Salvador Marques, Helio Brites da Silva   +2 more
doaj   +1 more source

From politics to economics: The investigation of the determinants of local administrative hierarchy in the Tang–Song transition

Asia‐Pacific Economic History Review, Volume 65, Issue 1, Page 39-78, March 2025.
Abstract This study collects original data to examine the determinants of classification criteria of county hierarchy and its rank variations during the Tang–Song period. The results reveal that the county hierarchy was affected by both economic and political situations, with more emphasis on politics in Tang and economics in Song.
Nan Li, Heqi Cai
wiley   +1 more source