Results 21 to 30 of about 14,328 (204)

Alteration of Bile Acids and Omega-6 PUFAs Are Correlated With the Progression and Prognosis of Drug-Induced Liver Injury

Frontiers in Immunology, 2022
Background & AimsDrug-induced liver injury (DILI) is one of the leading causes of liver failure with some of the patients progressed to chronic DILI.
Shuang Zhao, Haoshuang Fu, Tianhui Zhou, Minghao Cai, Yan Huang, Qinyi Gan, Chenxi Zhang, Cong Qian, Jiexiao Wang, Zhenglan Zhang, Xiaolin Wang, Xiaogang Xiang, Qing Xie   +12 more
doaj   +1 more source

DILI (drug induced liver injury) in a 9-month-old infant: a rare case of phenobarbital-induced hepatotoxicity

Journal of Pediatric and Neonatal Individualized Medicine, 2013
Phenobarbital is one of the most commonly prescribed antiepileptic drugs in childhood, but it can rarely cause serious adverse effects, such as hepatotoxicity that includes a broad clinical spectrum (from isolate hypertransaminasemia to acute liver ...
Anna Paola Pinna, Gabriella Locci, Maria Furno, Daniela Fanni, Gavino Faa, Anna Maria Nurchi   +5 more
doaj   +1 more source

A Computational Toxicology Approach to Screen the Hepatotoxic Ingredients in Traditional Chinese Medicines: Polygonum multiflorum Thunb as a Case Study

Biomolecules, 2019
In recent years, liver injury induced by Traditional Chinese Medicines (TCMs) has gained increasing attention worldwide. Assessing the hepatotoxicity of compounds in TCMs is essential and inevitable for both doctors and regulatory agencies.
Shuaibing He, Xuelian Zhang, Shan Lu, Ting Zhu, Guibo Sun, Xiaobo Sun   +5 more
doaj   +1 more source

COVID-19-Associated Liver Injury

Hepatic Medicine: Evidence and Research, 2023
Daniel T Gildea,1 Stephanie M Woo,2 Corinne E O’Connor,3 Amol S Rangnekar4 1Department of Internal Medicine, MedStar Georgetown University Hospital, Washington, DC, USA; 2Department of Gastroenterology, MedStar Georgetown University Hospital, Washington,
Gildea DT, Woo SM, O'Connor CE, Rangnekar AS   +3 more
doaj  

Exploratory Study of Autoantibody Profiling in Drug‐Induced Liver Injury with an Autoimmune Phenotype

Hepatology Communications, 2020
Drug‐induced liver injury (DILI) sometimes presents with an autoimmune hepatitis‐like phenotype (AI‐DILI), and it is challenging to distinguish it from de novo autoimmune hepatitis (AIH).
Craig Lammert, Chengsong Zhu, Yun Lian, Indu Raman, George Eckert, Quan‐Zhen Li, Naga Chalasani   +6 more
doaj   +1 more source

Distinction of Drug-Induced Liver Injury From Autoimmune Hepatitis in Patients With Acute Liver Injury: Proposal of a Combination of Diagnostic Scores

Gastro Hep Advances, 2023
Background and Aims: Acute liver injury (ALI) due to autoimmune hepatitis (AIH) can be treated by immunosuppression. In contrast, idiosyncratic drug-induced liver injury (DILI) had a poor prognosis.
Keisuke Kakisaka, Nobuaki Nakayama, Kotaro Kumagai, Takuro Hisanaga, Takayuki Kondo, Toru Setsu, Shunsuke Sato, Yohei Kooka, Kei Endo, Yuichi Yoshida, Takayoshi Oikawa, Hidekatsu Kuroda, Akio Miyasaka, Ryuzo Abe, Taka-aki Nakada, Yoshihiro Ikura, Kenichi Harada, Takuya Genda, Shuji Terai, Naoya Kato, Taro Takami, Akio Ido, Satoshi Mochida, Takayuki Matsumoto, Atsushi Tanaka   +24 more
doaj   +1 more source

Lesión hepática inducida por medicamentos secundaria al consumo de esteroides androgénicos

Gaceta Médica Boliviana
El uso de esteroides anabólicos de forma ilícita es un problema en aumento que se caracteriza por el desconocimiento sobre los potenciales efectos secundarios a estos productos. El uso ilegal de los mismos ha llevado a un infra diagnóstico de los eventos
Juan sebastian Theran Leon, Laura Yibeth Esteban Badillo   +1 more
doaj   +1 more source

Bismuth subcitrate, metronidazole and tetracycline – a rare cause of drug-induced liver injury

European Journal of Case Reports in Internal Medicine, 2023
Drug-induced liver injury (DILI) is a liver condition caused by any drug or toxic substance. The spectrum of DILI manifestations can range from asymptomatic elevation of liver enzymes to acute liver failure.
Carina Silva, Susana Merim, Rita Sevivas, João Mota, Alexandra Leitão   +4 more
doaj   +1 more source

Turmeric-Induced Hepatotoxicity: Report of 2 Cases

International Medical Case Reports Journal, 2021
Aalam Sohal,1 Dhuha Alhankawi,2 Sunny Sandhu,1 JayaKrishna Chintanaboina2 1Department of Internal Medicine, UCSF Fresno, Fresno, CA, USA; 2Department of Gastroenterology and Hepatology, UCSF Fresno, Fresno, CA, USACorrespondence: Aalam Sohal 155 N Fresno
Sohal A, Alhankawi D, Sandhu S, Chintanaboina J   +3 more
doaj  

Identification of average molecular weight (AMW) as a useful chemical descriptor to discriminate liver injury-inducing drugs.

PLoS ONE, 2021
Drug-induced liver injury (DILI) is one of major causes of discontinuing drug development and withdrawing drugs from the market. In this study, we investigated chemical properties associated with DILI using in silico methods, to identify a ...
Yuki Shimizu, Takamitsu Sasaki, Jun-Ichi Takeshita, Michiko Watanabe, Ryota Shizu, Takuomi Hosaka, Kouichi Yoshinari   +6 more
doaj   +1 more source