Results 11 to 20 of about 107,502 (231)
Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Journal of Pediatric and Neonatal Individualized Medicine, 2013 Phenobarbital is one of the most commonly prescribed antiepileptic drugs in childhood, but it can rarely cause serious adverse effects, such as hepatotoxicity that includes a broad clinical spectrum (from isolate hypertransaminasemia to acute liver ...
Anna Paola Pinna +5 more
doaj +1 more source
Biomolecules, 2019 In recent years, liver injury induced by Traditional Chinese Medicines (TCMs) has gained increasing attention worldwide. Assessing the hepatotoxicity of compounds in TCMs is essential and inevitable for both doctors and regulatory agencies.
Shuaibing He +5 more
doaj +1 more source
Exploration of Digestive Diseases, 2023 The late event onset of a fraction of idiosyncratic drug-induced liver injury (DILI) cases and the link observed by genome-wide association studies (GWASs) of certain human leucocyte antigen (HLA) alleles with DILI due to specific drugs support the ...
Alejandro Cueto-Sánchez +6 more
doaj +1 more source
Drug Hepatotoxicity: Environmental Factors [PDF]
, 2017 Drug-induced liver injury presents as various forms of acute and chronic liver disease. There is wide geographic variation in the most commonly implicated agents.
Chalasani, Naga P., Stine, Jonathan G.
core +1 more source
Drug-induced liver injury: An overview and update
Gastroenterology & Endoscopy, 2023 Drug-induced liver injury (DILI) is a relatively rare but important adverse event for a variety of commonly used drugs, herbal and dietary supplements, illegal drugs and novel agents.
Yujie Wang, Wen Xie
doaj +1 more source
Amoxicillin-Clavulanate-Induced Liver Injury [PDF]
, 2016 Background and Aims Amoxicillin–clavulanate (AC) is the most frequent cause of idiosyncratic drug-induced injury (DILI) in the US DILI Network (DILIN) registry.
Andrew S. deLemos +8 more
core +1 more source
Chronic Drug-Induced Liver Injury: Updates and Future Challenges
Frontiers in Pharmacology, 2021 Chronic drug-induced liver injury (DILI), defined as DILI with persistent liver injury more than one year after the first onset by the latest European guidelines, is a notable challenge globally with big issues of defining causality and establishing ...
Qiaoling Wang +6 more
doaj +1 more source
Increased TG to HDL-C ratio is associated with severity of drug-induced liver injury
Scientific Reports, 2023 We investigated the relationship between dyslipidemia and drug-induced liver injury (DILI), especially the level of triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) in severe DILI.
Xiaoqing Jia +6 more
doaj +1 more source