Results 11 to 20 of about 14,328 (204)

Clinical Significance of Acute Kidney Injury in Idiosyncratic Drug-Induced Liver Injury: A Multicentric Propensity Scores Matched Study. [PDF]

Clin Pharmacol Ther
Clinical significance of acute kidney injury in idiosyncratic drug‐induced liver injury: a multicentric propensity scores matched study. Evidence about the role of acute kidney injury (AKI) in idiosyncratic drug‐induced liver injury (DILI) is still scarce.
Pinazo-Bandera JM, Niu H, Toro-Ortiz JP, Medina-Caliz I, Sanabria-Cabrera J, Ortega-Alonso A, Robles-Díaz M, Di Zeo-Sanchez DE, Hernández N, Bessone F, Nunes V, Paraná R, Lucena MI, Andrade RJ, Alvarez-Alvarez I, García-Cortés M.   +15 more
europepmc   +2 more sources

Serum Hepatocyte Growth Factor Predicts Outcomes in Non-Acetaminophen Drug-Induced Acute Liver Failure. [PDF]

Liver Int
ABSTRACT Background and Aims Regenerative capacity and inflammatory responses are key determinants of outcome in acute liver failure (ALF). However, their prognostic significance in non‐acetaminophen drug‐induced liver injury with acute liver injury or ALF (non‐APAP‐DILI‐ALI/ALF) remains poorly defined.
Wang T, Bacot SM, Patterson K, Friedman D, Taylor C, Hong H, Liu J, Avigan MI, Hayashi P, Rule JA, Lee WM, Rakela J, Feldman GM, Chen M.   +13 more
europepmc   +2 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Multicenter Evaluation of Large Language Models Versus Hepatologists for Prognostic Prediction in Drug-Induced Liver Injury. [PDF]

Liver Int
ABSTRACT Background & Aims Drug‐induced liver injury (DILI) would progress to chronicity or death. Large language models (LLMs) may enhance clinical decision‐making, yet their utility relative to physicians in DILI remains unclear. Therefore, we evaluated their performance in predicting DILI outcomes.
Fu H, Du Y, Zhao G, Xiao Y, Song S, Zang X, Zhou T, Zhuang Y, Mo R, Lai R, Xie Q.   +10 more
europepmc   +2 more sources

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Cross-sectional study of antibiotic resistance to Escherichia coli and Salmonella spp. in cats in Yogyakarta, Indonesia, and Dili, Timor-Leste [PDF]

Veterinary World
Background and Aim: Antibiotics are used in veterinary clinics and animal hospitals to treat infectious diseases. However, the improper use of antibiotics causes antibiotic resistance, which threatens future disease therapeutics in pet animals.
Widagdo Sri Nugroho, Antonino Do Karmo, Gustaf Eifel Silalahi, Elphan Augusta Kajang, Putu Cri Devischa Gallantiswara   +4 more
doaj   +1 more source

Drug-induced liver injury: An overview and update

Gastroenterology & Endoscopy, 2023
Drug-induced liver injury (DILI) is a relatively rare but important adverse event for a variety of commonly used drugs, herbal and dietary supplements, illegal drugs and novel agents.
Yujie Wang, Wen Xie
doaj   +1 more source

Increased TG to HDL-C ratio is associated with severity of drug-induced liver injury

Scientific Reports, 2023
We investigated the relationship between dyslipidemia and drug-induced liver injury (DILI), especially the level of triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) in severe DILI.
Xiaoqing Jia, Xiaoting Zhang, Ming Yan, Dalong Sun, Rong Li, Na Yang, Zheng Luo   +6 more
doaj   +1 more source

Chronic Drug-Induced Liver Injury: Updates and Future Challenges

Frontiers in Pharmacology, 2021
Chronic drug-induced liver injury (DILI), defined as DILI with persistent liver injury more than one year after the first onset by the latest European guidelines, is a notable challenge globally with big issues of defining causality and establishing ...
Qiaoling Wang, Qiaoling Wang, Ang Huang, Jia-Bo Wang, Jia-Bo Wang, Zhengsheng Zou, Zhengsheng Zou   +6 more
doaj   +1 more source

Liquid Hydrocarbon Storage Tank Fires – How Prepared is your Facility?

Chemical Engineering Transactions, 2016
A major fire is a credible scenario for any site or installation that is involved in the storage of liquid hydrocarbons (oil and fuels). Similarly, a major explosion scenario (albeit less probable than a major fire scenario with respect to hydrocarbons ...
Dili Nwabueze
doaj   +1 more source