Results 11 to 20 of about 13,535 (197)

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Increased TG to HDL-C ratio is associated with severity of drug-induced liver injury

Scientific Reports, 2023
We investigated the relationship between dyslipidemia and drug-induced liver injury (DILI), especially the level of triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) in severe DILI.
Xiaoqing Jia, Xiaoting Zhang, Ming Yan, Dalong Sun, Rong Li, Na Yang, Zheng Luo   +6 more
doaj   +1 more source

Chronic Drug-Induced Liver Injury: Updates and Future Challenges

Frontiers in Pharmacology, 2021
Chronic drug-induced liver injury (DILI), defined as DILI with persistent liver injury more than one year after the first onset by the latest European guidelines, is a notable challenge globally with big issues of defining causality and establishing ...
Qiaoling Wang, Qiaoling Wang, Ang Huang, Jia-Bo Wang, Jia-Bo Wang, Zhengsheng Zou, Zhengsheng Zou   +6 more
doaj   +1 more source

Cross-sectional study of antibiotic resistance to Escherichia coli and Salmonella spp. in cats in Yogyakarta, Indonesia, and Dili, Timor-Leste [PDF]

Veterinary World
Background and Aim: Antibiotics are used in veterinary clinics and animal hospitals to treat infectious diseases. However, the improper use of antibiotics causes antibiotic resistance, which threatens future disease therapeutics in pet animals.
Widagdo Sri Nugroho, Antonino Do Karmo, Gustaf Eifel Silalahi, Elphan Augusta Kajang, Putu Cri Devischa Gallantiswara   +4 more
doaj   +1 more source

Alteration of Bile Acids and Omega-6 PUFAs Are Correlated With the Progression and Prognosis of Drug-Induced Liver Injury

Frontiers in Immunology, 2022
Background & AimsDrug-induced liver injury (DILI) is one of the leading causes of liver failure with some of the patients progressed to chronic DILI.
Shuang Zhao, Haoshuang Fu, Tianhui Zhou, Minghao Cai, Yan Huang, Qinyi Gan, Chenxi Zhang, Cong Qian, Jiexiao Wang, Zhenglan Zhang, Xiaolin Wang, Xiaogang Xiang, Qing Xie   +12 more
doaj   +1 more source

DEDE KORKUT’UN DİLİ

Selçuk Üniversitesi Türkiyat Araştırmaları Dergisi, 2021
Dede Korkut hikâyelerinin Ḳitāb-ı Dedem Ḳorḳud ʻAlā Lisān-ı Tāʼife-i Oġuzān (Dresden nüshası) ve Ḥikāyet-i Oġuz-nāme-yi Ḳazan Beg ve Ġayrı (Kazan nüshası) adlarını taşıyan iki nüshası bulunmaktadır. Ses ve şekil özellikleri dikkate alınarak Eski Anadolu Türkçesi eserleri arasında değerlendirilen Dede Korkut hikâyelerinin dili hakkında araştırmacılar ...
openaire   +5 more sources

Liquid Hydrocarbon Storage Tank Fires – How Prepared is your Facility?

Chemical Engineering Transactions, 2016
A major fire is a credible scenario for any site or installation that is involved in the storage of liquid hydrocarbons (oil and fuels). Similarly, a major explosion scenario (albeit less probable than a major fire scenario with respect to hydrocarbons ...
Dili Nwabueze
doaj   +1 more source

DILI (drug induced liver injury) in a 9-month-old infant: a rare case of phenobarbital-induced hepatotoxicity

Journal of Pediatric and Neonatal Individualized Medicine, 2013
Phenobarbital is one of the most commonly prescribed antiepileptic drugs in childhood, but it can rarely cause serious adverse effects, such as hepatotoxicity that includes a broad clinical spectrum (from isolate hypertransaminasemia to acute liver ...
Anna Paola Pinna, Gabriella Locci, Maria Furno, Daniela Fanni, Gavino Faa, Anna Maria Nurchi   +5 more
doaj   +1 more source

Distinction of Drug-Induced Liver Injury From Autoimmune Hepatitis in Patients With Acute Liver Injury: Proposal of a Combination of Diagnostic Scores

Gastro Hep Advances, 2023
Background and Aims: Acute liver injury (ALI) due to autoimmune hepatitis (AIH) can be treated by immunosuppression. In contrast, idiosyncratic drug-induced liver injury (DILI) had a poor prognosis.
Keisuke Kakisaka, Nobuaki Nakayama, Kotaro Kumagai, Takuro Hisanaga, Takayuki Kondo, Toru Setsu, Shunsuke Sato, Yohei Kooka, Kei Endo, Yuichi Yoshida, Takayoshi Oikawa, Hidekatsu Kuroda, Akio Miyasaka, Ryuzo Abe, Taka-aki Nakada, Yoshihiro Ikura, Kenichi Harada, Takuya Genda, Shuji Terai, Naoya Kato, Taro Takami, Akio Ido, Satoshi Mochida, Takayuki Matsumoto, Atsushi Tanaka   +24 more
doaj   +1 more source