Results 1 to 10 of about 34,830 (218)

From heart to brain: cognitive potential of propranolol and diltiazem through cholinergic enhancement via butyrylcholinesterase inhibition [PDF]

Frontiers in Pharmacology
BackgroundButyrylcholinesterase (BChE) has emerged as a promising therapeutic target in the treatment of Alzheimer’s disease (AD), particularly in its later stages when acetylcholinesterase (AChE) activity declines.
Celtia Domínguez-Fernández, Amit Kumar, Rajnish Kumar, Taher Darreh-Shori   +3 more
doaj   +2 more sources

Effects of an intravenous infusion of diltiazem on glomerular filtration rate, electrolyte excretion, and urine output in healthy dogs

Journal of Veterinary Internal Medicine, 2022
Background Acute kidney injury (AKI) in dogs has a high case fatality rate. Diltiazem might improve renal function, but effect of intravenous infusion has not been adequately studied in dogs.
Megan D. Kelley, Dorothy A. Thompson‐Butler, Matthew C. Tanner, Justin D. Thomason, William H. Whitehouse   +4 more
doaj   +1 more source

Effects of pre-treatment with metoprolol and diltiazem on cerebral ischemia/reperfusion-induced injuries

Brazilian Journal of Pharmaceutical Sciences, 2023
Stroke is one of the most important health concerns worldwide. Calcium ions accumulation in the nerve cells and increase in the catecholamines level of the brain following cerebral ischemia/reperfusion (I/R) are accompanied by damaging effects. Therefore,
Ghazaleh Sadrhaghighi, Samin Abbaszadeh, Shabnam Babataheri, Alireza Garjani, Hamid Soraya   +4 more
doaj   +1 more source

Lethal Diltiazem Poisoning [PDF]

Journal of Analytical Toxicology, 2002
A 60-year-old man presented to an emergency department 2 h after the ingestion of 8 g of diltiazem (about 40 slow-release capsules, 200 mg/each) in a suicide attempt. The subject was treated with a gastric lavage and activated charcoal; then, a temporary transvenous pacing was also inserted. Despite emergency pharmacological treatment, the subject died
ROMANO G, BARBERA, NUNZIATA GIUSEPPA ELISABETTA, ROSSITTO C, SPADARO G.   +3 more
openaire   +3 more sources

The effect of the very low dosage diltiazem on tacrolimus exposure very early after kidney transplantation: a randomized controlled trial

Scientific Reports, 2022
The objective of this study was to assess the effect of the very low dosage of diltiazem on tacrolimus exposure during the first week post-kidney transplantation, among cytochrome P450 (CYP) 3A5 expressers who did not receive diltiazem (EXplb), CYP3A5 ...
Teerada Susomboon, Yotsaya Kunlamas, Somratai Vadcharavivad, Attapong Vongwiwatana   +3 more
doaj   +1 more source

Blood pressure medication and acute kidney injury after intracerebral haemorrhage: an analysis of the ATACH-II trial

BMJ Neurology Open, 2023
Background Acute blood pressure (BP) reduction is standard of care after acute intracerebral haemorrhage (ICH). More acute BP reduction is associated with acute kidney injury (AKI).
Philip Bath, Yuan Luo, Anand Srivastava, Andrew M Naidech, Hanyin Wang, Meghan Hutch, Julianne Murphy, James Paparello   +7 more
doaj   +1 more source

Diltiazem inhibits breast cancer metastasis via mediating growth differentiation factor 15 and epithelial-mesenchymal transition

Oncogenesis, 2022
Migration and metastasis commonly happen to triple-negative breast cancer (TNBC) patients with advanced diseases. In many studies, it has been suggested that epithelial-mesenchymal transition (EMT) is one of the key mechanisms triggering cancer ...
Yen-Chang Chen, Chen-Teng Wu, Jia-Hong Chen, Cheng-Fang Tsai, Chen-Yun Wu, Pei-Chun Chang, Wei-Lan Yeh   +6 more
doaj   +1 more source

Concomitant Use of Diltiazem With Direct Oral Anticoagulants and Bleeding Risk in Atrial Fibrillation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Diltiazem, a moderate cytochrome P450 3A4 isozyme/P‐glycoprotein inhibitor, may potentiate the bleeding risk of direct oral anticoagulants (DOACs) through pharmacokinetic interactions.
Yunwen Xu, Alex R. Chang, Lesley A. Inker, Mara McAdams‐DeMarco, Morgan E. Grams, Jung‐Im Shin   +5 more
doaj   +1 more source

The Efficacy of Diltiazem Gel on Diminution of Patients’ Complaints After Anal Surgery [PDF]

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2007
Background and objectives Local pain and painful defecation are common patients’ complaints after anal surgery. Topical diltiazem, a calcium channel blocker, can decrease the tonicity of smooth muscles of anal sphincter and probably decrease the ...
J. Ashagh Hosseeyni, A. Ahmadi, A. Kachooie, A. Ashagh Hosseyni, H.R. Haj Aghajani, M.H. Yosefi   +5 more
doaj   +2 more sources

Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias [PDF]

, 2016
Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) hold promise for assessment of drug-induced arrhythmias and are being considered for use under the comprehensive in vitro proarrhythmia assay (CiPA).
Blinova, Ksenia, Brock, Mathew, Chan, Dulciana, Chvatal, Stacie, Crumb, William J., Galeotti, Loriano, Hortigon-Vinagre, Maria P., Johannesen, Lars, Lyn-Cook, Beverly, Millard, Daniel, Pang, Li, Ross, James, Smith, Godfrey, Stockbridge, Norman, Stohlman, Jayna, Strauss, David G., Vicente, Jose, Zamora Rodriguez, Victor   +17 more
core   +1 more source