Results 1 to 10 of about 55,609 (295)
Concomitant Use of Diltiazem With Direct Oral Anticoagulants and Bleeding Risk in Atrial Fibrillation [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022 Background Diltiazem, a moderate cytochrome P450 3A4 isozyme/P‐glycoprotein inhibitor, may potentiate the bleeding risk of direct oral anticoagulants (DOACs) through pharmacokinetic interactions.
Yunwen Xu +5 more
doaj +3 more sources
Oncogenesis, 2022 Migration and metastasis commonly happen to triple-negative breast cancer (TNBC) patients with advanced diseases. In many studies, it has been suggested that epithelial-mesenchymal transition (EMT) is one of the key mechanisms triggering cancer ...
Yen-Chang Chen +6 more
doaj +2 more sources
JEM Reports, 2023 Background: Atrial fibrillation (Afib) is the most commonly treated arrhythmia in the Emergency Department (ED). Multiple guidelines recommend the use of intravenous (IV) beta-blocking (BB) agents or nondihydropyridine calcium channel blockers (Non-DHP ...
Matt Blackburn +5 more
doaj +2 more sources
From heart to brain: cognitive potential of propranolol and diltiazem through cholinergic enhancement via butyrylcholinesterase inhibition [PDF]
Frontiers in PharmacologyBackgroundButyrylcholinesterase (BChE) has emerged as a promising therapeutic target in the treatment of Alzheimer’s disease (AD), particularly in its later stages when acetylcholinesterase (AChE) activity declines.
Celtia Domínguez-Fernández +3 more
doaj +2 more sources
Combined Effects of Benidipine and Diltiazem in a Rat Model of Experimental Angina
Journal of Pharmacological Sciences, 2004 We examined the combined effects of the calcium channel blockers 1,4-dihydropyridine (benidipine) and benzothiazepine (diltiazem) on vasopressin-induced myocardial ischemia in anesthetized rats, an experimental model of angina. Benidipine (3, 10 μg/kg, i.
Kozo Yao, Shiro Shirakura
doaj +3 more sources
Brazilian Journal of Pharmaceutical Sciences, 2023 Stroke is one of the most important health concerns worldwide. Calcium ions accumulation in the nerve cells and increase in the catecholamines level of the brain following cerebral ischemia/reperfusion (I/R) are accompanied by damaging effects. Therefore,
Ghazaleh Sadrhaghighi +4 more
doaj +1 more source
Journal of Veterinary Internal Medicine, 2022 Background Acute kidney injury (AKI) in dogs has a high case fatality rate. Diltiazem might improve renal function, but effect of intravenous infusion has not been adequately studied in dogs.
Megan D. Kelley +4 more
doaj +1 more source
Lethal Diltiazem Poisoning [PDF]
Journal of Analytical Toxicology, 2002 A 60-year-old man presented to an emergency department 2 h after the ingestion of 8 g of diltiazem (about 40 slow-release capsules, 200 mg/each) in a suicide attempt. The subject was treated with a gastric lavage and activated charcoal; then, a temporary transvenous pacing was also inserted. Despite emergency pharmacological treatment, the subject died
ROMANO G +3 more
openaire +3 more sources
Scientific Reports, 2022 The objective of this study was to assess the effect of the very low dosage of diltiazem on tacrolimus exposure during the first week post-kidney transplantation, among cytochrome P450 (CYP) 3A5 expressers who did not receive diltiazem (EXplb), CYP3A5 ...
Teerada Susomboon +3 more
doaj +1 more source
BMJ Neurology Open, 2023 Background Acute blood pressure (BP) reduction is standard of care after acute intracerebral haemorrhage (ICH). More acute BP reduction is associated with acute kidney injury (AKI).
Philip Bath +7 more
doaj +1 more source