Results 51 to 60 of about 4,992,572 (251)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

In Situ Synthesis of Tetradentate Dye for Construction of Three-Dimensional Homochiral Phosphor

, 2016
In Situ Synthesis of Tetradentate Dye for Construction of Three-Dimensional Homochiral ...
Xianhui Bu (1418323), Pingyun Feng (1418326), Tao Wu (16763), Jian Zhang (1682)   +3 more
core   +2 more sources

Dimensional Synthesis of Parallel Robots Using Bilevel Optimization for Design Optimization and Resolution of Functional Redundancy

Robotics
Parallel-kinematic machines or parallel robots have only been established in a few applications where their advantage over serial kinematics due to their high payload capacity, stiffness, or dynamics with their limited workspace-to-installation-space ...
Moritz Schappler
doaj   +1 more source

A Graph-Theory-Based Method for Topological and Dimensional Representation of Planar Mechanisms as a Computational Tool for Engineering Design

IEEE Access, 2019
In this paper, a graph-theory-based approach for representing planar mechanisms is presented, the Santiago Portilla method (SPM). From the corresponding adjacency matrix, SPM generates an extended matrix containing the complete characterization of a ...
Eric Santiago-Valenten, Edgar Alfredo Portilla-Flores, Efren Mezura-Montes, Eduardo Vega-Alvarado, Maria Barbara Calva-Yanez, Martin Pedroza-Villalba   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Parallel Pointing Systems Suitable for Robotic Total Stations: Selection, Dimensional Synthesis, and Accuracy Analysis

Machines
Robotic Total Stations (RTS) are fully automated theodolites with electronic distance measurement (EDM) that include a number of additional tools (e.g., camera, laser rangefinder, onboard computer, and tracking software, etc.) enabling them to work ...
Henrique Simas, Raffaele Di Gregorio, Roberto Simoni, Marco Gatti   +3 more
doaj   +1 more source

Performance-Based Design of the CRS-RRC Schoenflies-Motion Generator

Robotics, 2018
Rigid-body displacements obtained by combining spatial translations and rotations around axes whose direction is fixed in the space are named Shoenflies’ motions.
Raffaele Di Gregorio, Mattia Cattai, Henrique Simas   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Synthesis of knee mechanism for transfemoral prosthesis

Revista UIS Ingenierías
This paper presents the computational design and validation of a transfemoral prosthesis with a polycentric knee mechanism, based on kinematic synthesis and multibody dynamics.
Juan Camilo Salazar-Franco, Luz Adriana Mejía-Calderón   +1 more
doaj   +1 more source