Results 61 to 70 of about 4,992,572 (251)

RESEARCH ON THE OPTIMAL SYNTHESIS OF A MULTI-CONTOUR MECHANISM [PDF]

Romanian Journal of Petroleum & Gas Technology
The synthesis of mechanisms is a complex field of study that includes, in addition to the knowledge necessary for the correct configuration of working mechanisms and those necessary for their analysis, knowledge from the field of nonlinear programming ...
Dorin Bădoiu
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Optimization and Experimental Evaluation of a Legged Robot Mechanism Based on Task Space Partitioning

Fractal and Fractional
This study analyzed the spatial distribution characteristics of the foot-end trajectory of a robotic leg mechanism during different gait phases. Based on this analysis, a task space partition-based dimensional parameter optimization method was proposed ...
Bin Liu, Zhuo Wang, Wenjie Ge, Yonghong Zhang   +3 more
doaj   +1 more source

Low-Dimensional Nanomaterial Systems Formed by IVA Group Elements Allow Energy Conversion Materials to Flourish

, 2022
In response to the exhaustion of traditional energy, green and efficient energy conversion has attracted growing attention. The IVA group elements, especially carbon, are widely distributed and stable in the earth’s crust, and have received a lot of ...
Li, Dan, Nan Chen, Liru Wang, Lv, Jinsheng, Yang, Tian, Chen, Nan, Tian Yang, Ya’nan Yang, Yang, Ya’nan, Wang, Liru, Mengfan Shi, Jinsheng Lv, Shi, Mengfan, Dan Li   +13 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Direct laser synthesis of two-dimensional transition metal dichalcogenides

, 2019
We present the spatially selective synthesis, patterning and characterization of two dimensional MoS2 and WS2 layers using laser irradiation of single source precursors under ambient ...
Abbas, Omar Adnan, Aspiotis, Nikolaos, Lewis, Adam Henry, Sazio, Pier-John, Huang, Chung-Che, Zeimpekis, Ioannis, Mailis, Sakellaris, Hewak, Daniel   +7 more
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Chemical synthesis of two-dimensional atomic crystals, heterostructures and superlattices

, 2018
We present an overview of the recent advances, challenges and future perspectives on the chemical synthesis of two-dimensional atomic crystals, heterostructures and superlattices.
Xiangfeng Duan, Xidong Duan, Zhengwei Zhang, Peng Chen   +3 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source