Results 61 to 70 of about 139,695 (308)

Dimensionality Reduction with Image Data [PDF]

open access: yes, 2004
A common objective in image analysis is dimensionality reduction. The most common often used data-exploratory technique with this objective is principal component analysis. We propose a new method based on the projection of the images as matrices after a Procrustes rotation and show that it leads to a better reconstruction of images.
Peña, Daniel, Benito, Mónica
openaire   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Research on Dimensionality Reduction in Network Traffic Anomaly Detection [PDF]

open access: yesJisuanji gongcheng, 2020
To implement anomaly detection for a high dimensional network with mass flow data,data dimensionality should be reduced to relieve transmission and storage burdens from the system.This paper introduces network traffic anomaly detection process and ...
CHEN Liangchen, GAO Shu, LIU Baoxu, TAO Mingfeng
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Nonlinear dimensionality reduction in climate data [PDF]

open access: yesNonlinear Processes in Geophysics, 2004
Linear methods of dimensionality reduction are useful tools for handling and interpreting high dimensional data. However, the cumulative variance explained by each of the subspaces in which the data space is decomposed may show a slow convergence that ...
A. J. Gámez   +3 more
doaj  

Dimensionality Reduction by Similarity Distance-Based Hypergraph Embedding

open access: yesAtmosphere, 2022
Dimensionality reduction (DR) is an essential pre-processing step for hyperspectral image processing and analysis. However, the complex relationship among several sample clusters, which reveals more intrinsic information about samples but cannot be ...
Xingchen Shen, Shixu Fang, Wenwen Qiang
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

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