Results 71 to 80 of about 679,917 (339)

Antioxidant Mechanisms of Echinatin and Licochalcone A

Molecules, 2018
Echinatin and its 1,1-dimethyl-2-propenyl derivative licochalcone A are two chalcones found in the Chinese herbal medicine Gancao. First, their antioxidant mechanisms were investigated using four sets of colorimetric measurements in this study.
Minshi Liang, Xican Li, Xiaojian Ouyang, Hong Xie, Dongfeng Chen   +4 more
doaj   +1 more source

Infinite series of magnetization plateaus in the frustrated dimer-plaquette chain

, 2001
The dimer-plaquette chain undergoes a first order transition driven by frustration to an orthogonal dimer ground state. We analyze the magnetization curve in this orthogonal dimer regime.
Richter, J., Schulenburg, J.
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Study of the experimental and simulated vibrational spectra together with conformational analysis for thioether cyanobiphenyl-based liquid crystal dimers [PDF]

, 2022
Barbara Loska, A. Kocot, Yuki Arakawa, G. H. Mehl, Katarzyna Merkel   +4 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

14-3-3σ and Its Modulators in Cancer

Pharmaceuticals, 2020
14-3-3σ is an acidic homodimer protein with more than one hundred different protein partners associated with oncogenic signaling and cell cycle regulation.
Ghazi Aljabal, Beow Keat Yap
doaj   +1 more source

On the Red-Green-Blue Model

, 2002
We experimentally study the red-green-blue model, which is a sytem of loops obtained by superimposing three dimer coverings on offset hexagonal lattices. We find that when the boundary conditions are ``flat'', the red-green-blue loops are closely related
B. Duplantier, C. Fortuin, David B. Wilson, H. Cohn, H. Cohn, H. Cohn, H.W.J. Blöte, J. Cardy, J. Chayes, J. Kondev, J.G. Propp, L.S. Levitov, O. Schramm, R. Kenyon, R. Kenyon, R. Langlands, R.W. Kenyon, W. Thurston, W. Zheng   +18 more
core   +1 more source

P∩N Bridged Cu(I) Dimers Featuring Both TADF and Phosphorescence. From Overview towards Detailed Case Study of the Excited Singlet and Triplet States [PDF]

, 2021
Thomas Hofbeck, Thomas A. Niehaus, Μ. Fleck, Uwe Monkowius, Hartmut Yersin   +4 more
openalex   +1 more source