In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus [PDF]
Toxicon: X, 2022 Snakebite envenoming affects more than 250,000 people annually in sub-Saharan Africa. Envenoming by Dispholidus typus (boomslang) results in venom-induced consumption coagulopathy (VICC), whereby highly abundant prothrombin-activating snake venom ...
Stefanie K. Menzies +11 more
doaj +10 more sources
Snakebite drug discovery: high-throughput screening to identify novel snake venom metalloproteinase toxin inhibitors [PDF]
Frontiers in Pharmacology, 2023 Snakebite envenoming results in ∼100,000 deaths per year, with close to four times as many victims left with life-long sequelae. Current antivenom therapies have several limitations including high cost, variable cross-snake species efficacy and a ...
Rachel H. Clare +15 more
doaj +2 more sources
Neutralizing Effects of Small Molecule Inhibitors and Metal Chelators on Coagulopathic Viperinae Snake Venom Toxins [PDF]
Biomedicines, 2020 Animal-derived antivenoms are the only specific therapies currently available for the treatment of snake envenoming, but these products have a number of limitations associated with their efficacy, safety and affordability for use in tropical snakebite ...
Chunfang Xie +6 more
doaj +5 more sources
Technology in Cancer Research & Treatment, 2021 Objective: To investigate the efficacy of a formula comprising arsenic trioxide and dimercaprol (BAL-ATO) as a radiosensitizing agent in model mice with pancreatic cancer xenografts. Methods: Female BALB/c nude mice bearing SW1990 human pancreatic cancer
Renyan Tang MD +4 more
doaj +2 more sources
Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms [PDF]
Acta Pharmaceutica Sinica B, 2020 Repurposing small molecule drugs and drug candidates is considered as a promising approach to revolutionise the treatment of snakebite envenoming. In this study, we investigated the inhibiting effects of the small molecules varespladib (nonspecific ...
Chunfang Xie +6 more
doaj +6 more sources
Increasing glutathione levels by a novel posttranslational mechanism inhibits neuronal hyperexcitability [PDF]
Redox Biology, 2023 Glutathione (GSH) depletion, and impaired redox homeostasis have been observed in experimental animal models and patients with epilepsy. Pleiotropic strategies that elevate GSH levels via transcriptional regulation have been shown to significantly ...
Ashwini Sri Hari +8 more
doaj +2 more sources
Lead encephalopathy presenting as status epilepticus: a case report [PDF]
BMC PediatricsBackground Lead encephalopathy, while thankfully rare, is a devastating and potentially fatal consequence of lead intoxication. Owing to successful public health measures, severe lead toxicity is not often encountered by most practicing physicians in the
Iqra J. Kamal +4 more
doaj +2 more sources
Pharmacological elevation of glutathione inhibits status epilepticus-induced neuroinflammation and oxidative injury [PDF]
Redox BiologyGlutathione (GSH) is a major endogenous antioxidant, and its depletion has been observed in several brain diseases including epilepsy. Previous studies in our laboratory have shown that dimercaprol (DMP) can elevate GSH via post-translational activation ...
Li-Ping Liang +3 more
doaj +2 more sources
Recent advances in the clinical management of intoxication by five heavy metals: Mercury, lead, chromium, cadmium and arsenic [PDF]
HeliyonMetals have been used for many centuries, but their nutritional and toxic effects have been investigated since the last century. The common toxic heavy metals (THM) include mercury, lead, chromium cadmium, and arsenic.
Mahdi Balali-Mood +6 more
doaj +2 more sources
Development of a Library of Disulfide Bond-Containing Cationic Lipids for mRNA Delivery
Pharmaceutics, 2023 Lipid nanoparticles (LNPs) are the commonly used delivery tools for messenger RNA (mRNA) therapy and play an indispensable role in the success of COVID-19 mRNA vaccines. Ionizable cationic lipids are the most important component in LNPs.
Zhigao Shen +8 more
doaj +1 more source