Results 1 to 10 of about 1,164 (93)

ALDH1a3 Protects Against Iron Overload-Induced Oxidative Stress and Mitochondrial Impairment in Renal Tubular Epithelial Cells. [PDF]

Antioxidants (Basel)
Iron overload significantly contributes to chronic kidney disease progression by triggering oxidative stress and mitochondrial impairment via the Fenton reaction.
Wei T, Xiong Z, Wang T, Huang C, Luo Q, Shi R, Jia L, Liu W, Yang D, Chen Z.   +9 more
europepmc   +2 more sources

Dimercaprol Reprograms Intestinal Redox Homeostasis and Organelle Crosstalk to Combat Iron-Induced Gut Dysbiosis Through NRF2/HO-1 Signaling. [PDF]

Antioxidants (Basel)
Gut disorders are largely caused by iron-induced microbial dysbiosis. Excess iron disrupts barrier integrity by inducing oxidative stress, leading to impaired cellular processes.
Khan A, Xiong Z, Khan IA, Cheng X, Luo Q, Jia L, Liu W, Huang C, Chen Z.   +8 more
europepmc   +2 more sources

Formulation Comprising Arsenic Trioxide and Dimercaprol Enhances Radiosensitivity of Pancreatic Cancer Xenografts

Technology in Cancer Research and Treatment, 2021
Objective: To investigate the efficacy of a formula comprising arsenic trioxide and dimercaprol (BAL-ATO) as a radiosensitizing agent in model mice with pancreatic cancer xenografts. Methods: Female BALB/c nude mice bearing SW1990 human pancreatic cancer
Jinbin Han
exaly   +2 more sources

Dimercaprol (BAL): Insights into conformational stability, fragmentation pathways via tandem LR-ESI, HR-EI mass spectrometry, and gas-phase thermochemical properties from quantum chemical calculations. [PDF]

PLoS One
Dimercaprol (British antilewisite, BAL) is a long-established chelating agent used in the treatment of heavy metal poisoning; however, its physicochemical and thermochemical properties have not yet been fully characterized. In this study, we combined gas-
Molano MF, Gómez Gómez AM, Moncayo-Lasso A, Bejarano CA, Diaz JE, Buendía-Atencio C, Delgado MÁ, Lorett Velásquez VP, Loaiza AE, Mejía SM.   +9 more
europepmc   +2 more sources

Snakebite drug discovery: high-throughput screening to identify novel snake venom metalloproteinase toxin inhibitors. [PDF]

Front Pharmacol, 2023
Snakebite envenoming results in ∼100,000 deaths per year, with close to four times as many victims left with life-long sequelae. Current antivenom therapies have several limitations including high cost, variable cross-snake species efficacy and a ...
Clare RH, Dawson CA, Westhorpe A, Albulescu LO, Woodley CM, Mosallam N, Chong DJW, Kool J, Berry NG, O'Neill PM, Casewell NR.   +10 more
europepmc   +2 more sources

Clinical characteristics, management, and outcomes of diseases caused by mercury overexposure: a systematic review of case reports and case series. [PDF]

Front Public Health
BackgroundMercury poisoning remains a serious public health issue due to its multiple exposure routes and diverse clinical presentations. However, existing clinical evidence is fragmented, especially regarding real-world case data.
Shi Y, Wang M, Ni H, Lin S, Ma D, Zhou Z, Ji C.   +6 more
europepmc   +2 more sources

Increasing glutathione levels by a novel posttranslational mechanism inhibits neuronal hyperexcitability. [PDF]

Redox Biol, 2023
Glutathione (GSH) depletion, and impaired redox homeostasis have been observed in experimental animal models and patients with epilepsy. Pleiotropic strategies that elevate GSH levels via transcriptional regulation have been shown to significantly ...
Sri Hari A, Banerji R, Liang LP, Fulton RE, Huynh CQ, Fabisiak T, McElroy PB, Roede JR, Patel M.   +8 more
europepmc   +2 more sources

Lead encephalopathy presenting as status epilepticus: a case report. [PDF]

BMC Pediatr
Background Lead encephalopathy, while thankfully rare, is a devastating and potentially fatal consequence of lead intoxication. Owing to successful public health measures, severe lead toxicity is not often encountered by most practicing physicians in the
Kamal IJ, Cerbini T, Clouser A, Hernandez A, Calello DP.   +4 more
europepmc   +2 more sources

Pharmacological elevation of glutathione inhibits status epilepticus-induced neuroinflammation and oxidative injury. [PDF]

Redox Biol
Glutathione (GSH) is a major endogenous antioxidant, and its depletion has been observed in several brain diseases including epilepsy. Previous studies in our laboratory have shown that dimercaprol (DMP) can elevate GSH via post-translational activation ...
Liang LP, Sri Hari A, Day BJ, Patel M.
europepmc   +2 more sources

Recent advances in the clinical management of intoxication by five heavy metals: Mercury, lead, chromium, cadmium and arsenic. [PDF]

Heliyon
Metals have been used for many centuries, but their nutritional and toxic effects have been investigated since the last century. The common toxic heavy metals (THM) include mercury, lead, chromium cadmium, and arsenic.
Balali-Mood M, Eizadi-Mood N, Hassanian-Moghaddam H, Etemad L, Moshiri M, Vahabzadeh M, Sadeghi M.   +6 more
europepmc   +2 more sources