Results 1 to 10 of about 2,161 (189)

Dimercaprol Reprograms Intestinal Redox Homeostasis and Organelle Crosstalk to Combat Iron-Induced Gut Dysbiosis Through NRF2/HO-1 Signaling [PDF]

Antioxidants
Gut disorders are largely caused by iron-induced microbial dysbiosis. Excess iron disrupts barrier integrity by inducing oxidative stress, leading to impaired cellular processes.
Asad Khan, Zongliang Xiong, Iftikhar Ali Khan, Xiangyu Cheng, Qihui Luo, Lanlan Jia, Wentao Liu, Chao Huang, Zhengli Chen   +8 more
doaj   +2 more sources

Snakebite drug discovery: high-throughput screening to identify novel snake venom metalloproteinase toxin inhibitors [PDF]

Frontiers in Pharmacology, 2023
Snakebite envenoming results in ∼100,000 deaths per year, with close to four times as many victims left with life-long sequelae. Current antivenom therapies have several limitations including high cost, variable cross-snake species efficacy and a ...
Rachel H. Clare, Rachel H. Clare, Charlotte A. Dawson, Charlotte A. Dawson, Adam Westhorpe, Adam Westhorpe, Laura-Oana Albulescu, Laura-Oana Albulescu, Christopher M. Woodley, Nada Mosallam, Daniel J. W. Chong, Jeroen Kool, Neil G. Berry, Paul M. O’Neill, Nicholas R. Casewell, Nicholas R. Casewell   +15 more
doaj   +2 more sources

Neutralizing Effects of Small Molecule Inhibitors and Metal Chelators on Coagulopathic Viperinae Snake Venom Toxins [PDF]

Biomedicines, 2020
Animal-derived antivenoms are the only specific therapies currently available for the treatment of snake envenoming, but these products have a number of limitations associated with their efficacy, safety and affordability for use in tropical snakebite ...
Chunfang Xie, Laura-Oana Albulescu, Mátyás A. Bittenbinder, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Jeroen Kool   +6 more
doaj   +5 more sources

Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms [PDF]

Acta Pharmaceutica Sinica B, 2020
Repurposing small molecule drugs and drug candidates is considered as a promising approach to revolutionise the treatment of snakebite envenoming. In this study, we investigated the inhibiting effects of the small molecules varespladib (nonspecific ...
Chunfang Xie, Julien Slagboom, Laura-Oana Albulescu, Govert W. Somsen, Freek J. Vonk, Nicholas R. Casewell, Jeroen Kool   +6 more
doaj   +6 more sources

Lead encephalopathy presenting as status epilepticus: a case report [PDF]

BMC Pediatrics
Background Lead encephalopathy, while thankfully rare, is a devastating and potentially fatal consequence of lead intoxication. Owing to successful public health measures, severe lead toxicity is not often encountered by most practicing physicians in the
Iqra J. Kamal, Trevor Cerbini, Amanda Clouser, Aileen Hernandez, Diane P. Calello   +4 more
doaj   +2 more sources

Increasing glutathione levels by a novel posttranslational mechanism inhibits neuronal hyperexcitability [PDF]

Redox Biology, 2023
Glutathione (GSH) depletion, and impaired redox homeostasis have been observed in experimental animal models and patients with epilepsy. Pleiotropic strategies that elevate GSH levels via transcriptional regulation have been shown to significantly ...
Ashwini Sri Hari, Rajeswari Banerji, Li-Ping Liang, Ruth E. Fulton, Christopher Quoc Huynh, Timothy Fabisiak, Pallavi Bhuyan McElroy, James R. Roede, Manisha Patel   +8 more
doaj   +2 more sources

Clinical characteristics, management, and outcomes of diseases caused by mercury overexposure: a systematic review of case reports and case series [PDF]

Frontiers in Public Health
BackgroundMercury poisoning remains a serious public health issue due to its multiple exposure routes and diverse clinical presentations. However, existing clinical evidence is fragmented, especially regarding real-world case data.
Yun Shi, Minyan Wang, Haojie Ni, Sisi Lin, Dieyu Ma, Zhizhen Zhou, Conghua Ji   +6 more
doaj   +2 more sources

Pharmacological elevation of glutathione inhibits status epilepticus-induced neuroinflammation and oxidative injury [PDF]

Redox Biology
Glutathione (GSH) is a major endogenous antioxidant, and its depletion has been observed in several brain diseases including epilepsy. Previous studies in our laboratory have shown that dimercaprol (DMP) can elevate GSH via post-translational activation ...
Li-Ping Liang, Ashwini Sri Hari, Brian J. Day, Manisha Patel   +3 more
doaj   +2 more sources

Recent advances in the clinical management of intoxication by five heavy metals: Mercury, lead, chromium, cadmium and arsenic [PDF]

Heliyon
Metals have been used for many centuries, but their nutritional and toxic effects have been investigated since the last century. The common toxic heavy metals (THM) include mercury, lead, chromium cadmium, and arsenic.
Mahdi Balali-Mood, Nastaran Eizadi-Mood, Hossein Hassanian-Moghaddam, Leila Etemad, Mohammad Moshiri, Maryam Vahabzadeh, Mahmood Sadeghi   +6 more
doaj   +2 more sources

In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typus

Toxicon: X, 2022
Snakebite envenoming affects more than 250,000 people annually in sub-Saharan Africa. Envenoming by Dispholidus typus (boomslang) results in venom-induced consumption coagulopathy (VICC), whereby highly abundant prothrombin-activating snake venom ...
Stefanie K. Menzies, Rachel H. Clare, Chunfang Xie, Adam Westhorpe, Steven R. Hall, Rebecca J. Edge, Jaffer Alsolaiss, Edouard Crittenden, Amy E. Marriott, Robert A. Harrison, Jeroen Kool, Nicholas R. Casewell   +11 more
doaj   +1 more source