Results 101 to 110 of about 28,189 (202)

Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects. [PDF]

, 2017
Fumarate hydratase (FH) is an enzyme of the tricarboxylic acid (TCA) cycle mutated in hereditary and sporadic cancers. Despite recent advances in understanding its role in tumorigenesis, the effects of FH loss on mitochondrial metabolism are still ...
Bridges, Hannah R, D'Santos, Clive, Frezza, Christian, Gaude, Edoardo, Griffiths, John R, Hernandez-Fernaud, Juan, Hirst, Judy, Papachristou, Evangelia K, Schreiner, Alexander, Sciacovelli, Marco, Springett, Roger, Tyrakis, Petros A, Yurkovich, Marie E   +12 more
core   +2 more sources

Protective Role for Itaconate During Inhaled Allergen Challenge

Allergy, Volume 81, Issue 4, Page 1099-1110, April 2026.
Itaconate levels decrease in sputum following allergen inhalation in mild asthmatics, suggesting a dynamic metabolic response to airway challenge. Genetic deletion of Acod1 in mice did not alter airway inflammation or remodelling in response to chronic HDM exposure.
Gesa J. Albers, Patricia P. Ogger, Christina Michalaki, Helen Stölting, Simone A. Walker, Anna Caldwell, John M. Halket, Kathryn Duvall, Atia Batool, Lisha Joshi, Helen O'Brien, Cormac McCarthy, Timothy Hinks, Gail M. Gauvreau, Paul M. O'Byrne, Clare M. Lloyd, Adam J. Byrne   +16 more
wiley   +1 more source

6‐Methylsulfinylhexyl isothiocyanate activates carbonic anhydrase‐dependent HCO3−/H+/Na+/Ca2+ transport via SLC4As–NHE–NCX–PMCA axis in odontoblasts

The Journal of Physiology, Volume 604, Issue 7, Page 2816-2844, 1 April 2026.
Abstract figure legend 6‐Methylsulfinylhexyl isothiocyanate (6‐MSITC, hexaraphane), a wasabi sulfinyl compound, activates intracellular carbonic anhydrase (CA)‐mediated sequential HCO3−, Na+, H+ and Ca2+ transport through an activation axis involving HCO3−‐transporting solute carrier family 4 (SLC4As), the Na+–H+ exchanger (NHE), the Na+–Ca2+ exchanger
Yoshiaki Furusawa, Maki Kimura, Isao Okunishi, Takehito Ouchi, Ryuya Kurashima, Tomoe Katou‐Yamada, Hidetaka Kuroda, Makoto Sugita, Masahiro Furusawa, Yoshiyuki Shibukawa   +9 more
wiley   +1 more source

Impact of Textile Architecture on the Electromechanical Behavior of Conductive Carbon: Silicone Composite Strain Sensors

Advanced Engineering Materials, Volume 28, Issue 6, 18 March 2026.
A stretchable carbon composite is integrated by stencil printing onto two different types of textile, with different yarn morphologies. The impact of the knit structure and coating direction on the performance of the sensor composite is evaluated and used to derive a model estimating nominal resistance at a given strain near the percolation threshold ...
Gabriela Ananieva, Giulia Spallanzani, Peter Zalar   +2 more
wiley   +1 more source

Therapeutic efficacy of dimethyl fumarate in relapsing-remitting multiple sclerosis associates with ROS pathway in monocytes

Nature Communications, 2019
Dimethyl fumarate (DMF) is an established treatment for relapsing multiple sclerosis with unclear mechanism of action. Here the authors distinguish DMF responders by monocyte counts and redox gene signature in a prospective longitudinal cohort at 3 month
Karl E. Carlström, Ewoud Ewing, Mathias Granqvist, Alexandra Gyllenberg, Shahin Aeinehband, Sara Lind Enoksson, Antonio Checa, Tejaswi V. S. Badam, Jesse Huang, David Gomez-Cabrero, Mika Gustafsson, Faiez Al Nimer, Craig E. Wheelock, Ingrid Kockum, Tomas Olsson, Maja Jagodic, Fredrik Piehl   +16 more
doaj   +1 more source

Lymphopenia in treatment-naive relapsing multiple sclerosis

, 2016
Lymphopenia accompanies some autoimmune diseases. A number of studies, but not others, have suggested that lymphopenia occurs in treatment-naive multiple sclerosis (MS), so the issue remains unresolved. This is important since lymphopenia may identify an
Elwood, Elliot, Galea, Ian, Lim, Zhi Wei, Naveed, Hammad   +3 more
core   +1 more source

Oxidative aromatization of olefins with dioxygen catalyzed by palladium trifluoroacetate [PDF]

, 2008
Molecular oxygen can replace sacrificial olefins as the hydrogen acceptor in the palladium trifluoroacetate catalyzed dehydrogenation of cyclohexene and related cyclic olefins into aromatics.
Bercaw, John E., Hazari, Nilay, Labinger, Jay A.   +2 more
core  

Oxalates as Activating Groups for Alcohols in Visible Light Photoredox Catalysis: Formation of Quaternary Centers by Redox-Neutral Fragment Coupling. [PDF]

, 2015
Alkyl oxalates are new bench-stable alcohol-activating groups for radical generation under visible light photoredox conditions. Using these precursors, the first net redox-neutral coupling of tertiary and secondary alcohols with electron-deficient ...
Jamison, Christopher R, MacMillan, David WC, Nawrat, Christopher C, Overman, Larry E, Slutskyy, Yuriy   +4 more
core  

The lead tetra-acetate oxidations of some N-arylaminofumarates in the presence of trifluoroacetic acid [PDF]

, 1985
p-Chloroanilino-, p-acetylanilino-, and p-toluidinojumarates are oxidized by lead tetraacetate in low yields to give oxanzlate. Similar oxidation of p-acetylan Nnofumarate in the presence of trifluoroacetic add affords only oxanilate. p- Toluidino and
Sukari, Mohd Aspollah
core  

Achievement of No Evidence of Disease Activity-3 with Oral Disease-Modifying Treatment in Patients with Relapsing–Remitting Multiple Sclerosis

Saudi Journal of Medicine and Medical Sciences
Background There is scant data regarding the use of oral disease-modifying treatments (oDMT) in patients with relapsing–remitting multiple sclerosis (PwRRMS) from Saudi Arabia.
Foziah Jabbar Gossab Alshamrani, Azra Zafar, Rahmah Majed Alsawad, Zakia Yasawy, Rizwana Shahid, Saima Nazish, Erum Shariff, Nehad Mahmoud Soltan   +7 more
doaj   +1 more source