Results 21 to 30 of about 246,439 (294)

4-Amino-3-[2-(9H-carbazol-9-yl)ethyl]-1H-1,2,4-triazole-5(4H)-thione dimethyl sulfoxide monosolvate

IUCrData, 2016
In the crystal of the title compound, C16H15N5S·C2H6OS, both the 1,2,4-triazole derivative molecules and the disordered [refined occupancy ratio = 0.604 (1):0.396 (1)] dimethyl sulfoxide solvent molecules form centrosymmetric dimers, by way of pairwise N—
Joel T. Mague, Shaaban K. Mohamed, Mehmet Akkurt, Talaat I. El-Emary, Mustafa R. Albayati   +4 more
doaj   +1 more source

Di-μ-oxido-bis({2-[(R,R)-(−)-(2-aminocyclohexyl)iminomethyl]-4-nitrophenolato-κ3N,N′,O}oxidovanadium(V)) dimethyl sulfoxide disolvate

Acta Crystallographica Section E, 2009
The title compound, [V2(C13H16N3O3)2O4]·2C2H6OS, is a centrosymmetric dimeric complex solvated by two dimethyl sulfoxide molecules. Each VV atom is six-coordinated by one oxide group, two N atoms and one O atom from the tridentate Schiff base ligand,
Grzegorz Romanowski, Michał Wera, Artur Sikorski   +2 more
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Tolerance of Chicks for Dimethyl Sulfoxide

Poultry Science, 1972
Abstract Studies were conducted to determine levels of dimethyl sulfoxide (DMSO) that could be administered to chicks without toxic effect. The LD50 of a single dose of DMSO in day-old chicks was between 10.0 and 12.5 ml. per kg. body weight (b.w.) by oral administration and between 7.5 and 10.0 ml. per kg. b.w. by subcutaneous injection. The maximum
D. C. Foss, L. B. Carew
openaire   +3 more sources

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

FEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera, Camille C. Caldeira da Silva, Maiza Von Denz, Mauricio S. Baptista, Alicia J. Kowaltowski   +4 more
wiley   +1 more source

[1,2-Bis(diphenylphosphanyl)ethane-κ2P,P′]dichloridopalladium(II) dimethyl sulfoxide monosolvate

Acta Crystallographica Section E, 2012
In the title compound, [PdCl2(C26H24P2)]·C2H6OS, the PdII atom adopts a distorted cis-PdCl2P2 square-planar coordination geometry. The five-membered chelate ring adopts an envelope conformation with a methylene C atom in the flap position. The S
Ismail Warad, Abdullah S. Aldwayyan, Fahad M. Al-Jekhedab, M. Iqbal Choudhary, Sammer Yousuf   +4 more
doaj   +1 more source

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

Molecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo, Carlos M. Martínez‐Cáceres, Manuel Bernabé‐García, Vicente Munitiz, David Ruiz de Angulo, Pascual Parrilla, Ángeles Ortiz, Luisa F. Martínez de Haro, María L. Cayuela   +8 more
wiley   +1 more source

trans-Bis(3-hydroxypyridine-κN)diiodidoplatinum(II) dimethyl sulfoxide disolvate

Acta Crystallographica Section E, 2011
In the title compound, [PtI2(C5H5NO)2]·2(CH3)2SO, the PtII ion lies on an inversion center and is coordinated in a slightly distorted square-planar environment by two trans iodide ligands and two pyridine N atoms.
Fazlul Huq, Muhammed Danish, Wojciech Starosta, Janusz Leciejewicz   +3 more
doaj   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Dichlorido{N-[2-(diphenylphosphanyl)benzylidene]isopropylamine-κ2N,P}palladium(II) dimethyl sulfoxide monosolvate

Acta Crystallographica Section E, 2011
In the title PdII complex, [PdCl2(C22H22NP)]·(CH3)2SO, the PdII atom is coordinated in an NPCl2 coordination sphere by the N(imino) and P(phosphane) atoms of the ligand and by two Cl− ions in a slightly distorted square-planar geometry
Haleden Chiririwa, Reinout Meijboom, Bernard Omondi   +2 more
doaj   +1 more source