Results 171 to 180 of about 2,930 (198)
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Studies on several 7-substituted N,N-dimethyltryptamines
Journal of Medicinal Chemistry, 1980Several 7-substituted derivatives of N,N-dimethyltryptamine (DMT) were prepared and evaluated in the rat fundus serotonin receptor assay and in a behavioral (discriminative stimulus) assay in rats. Both 7-Me- and 5-OMe-7-Me-DMT possess a higher pA2, and 5,7-(OMe)2-DMT a lower pA2, than that of DMT itself.
R A, Glennon +3 more
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Neuromodulatory mechanisms of N,N-dimethyltryptamine
Brain Network and Modulation, 2023N,N-dimethyltryptamine (DMT) is the simplest psychedelic tryptamine and is produced naturally by many plant and animal species, including humans. While classical psychedelics, such as lysergic acid diethylamide, or psilocybin, are gaining interest because of their therapeutic potential, DMT has yet to be fully investigated ...
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Dimethyltryptamine (DMT) a Psychedelic
2009DMT, also known as N,N-dimethyltryptamine, is a naturally-occurring tryptamine and potent psychedelic drug, found not only in many plants, but also in trace amounts in the human body where its natural function is undetermined. Structurally, it is analogous to the neurotransmitter serotonin and other psychedelic tryptamines such as 5-MeO-DMT and 4-HO ...
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N,N-dimethyltryptamine like substance in rat brain
Life Sciences, 1973Abstract Rat brain contains 8 μg/g of a tertiary amine, very probably N,N-dimethyltryptamine as shown by bidimensional thin layer and gas ohromatography. Pretreatment with Nialamide did not modify the concentration of this substance in the brain.
B, Heller, E, Fischer, H, Spats
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Hydroxylation and N-demethylation of N,N-dimethyltryptamine
Experientia, 1959Der intermediare Stoffwechsel des psychotropen N,N-Dimethyltryptamins wurde untersucht. N-Methyltryptamin, als Produkt der Demethylierung, und 6-Hydroxy-N,N-Dimethyltryptamin, als Produkt der Hydroxylierung, wurden nachgewiesen und papierchromatographisch charakterisiert.
S, SZARA, J, AXELROD
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Endogenous psychoactive tryptamines reconsidered: an anxiolytic role for dimethyltryptamine
Medical Hypotheses, 2005The presence of the potent hallucinogenic psychoactive chemical N,N-dimethyltryptamine (DMT) in the human body has puzzled scientists for decades. Endogenous DMT was investigated in the 1960s and 1970s and it was proposed that DMT was involved in psychosis and schizophrenia.
Michael S, Jacob, David E, Presti
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N,N-Dimethyltryptamine: DMT-induced psychosis
The American Journal of Emergency Medicine, 2020David, Barbic +3 more
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Increased synthesis of striatal dopamine by N,N-dimethyltryptamine
Life Sciences, 1977Abstract The effect of acute doses of N,N-dimethyltryptamine (DMT) on the synthesis or degradation rates of rat diencephalon norepinephrine and striatal dopamine was estimated by administering 150 μCi L-tyrosine-3,5- 3 H at various times before sacrifice. In all cases DMT, 20 mg/kg, was injected one-half hour before sacrifice.
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The biosynthesis of dimethyltryptamine in vivo.
Research communications in chemical pathology and pharmacology, 1977The in vivo formation of dimethyltryptamine was studied in rabbits, rats and monkeys. When C14-labelled N-methyltryptamine was administered by intravenous injection to rabbits, C14-dimethyltryptamine was found in lung, the principle site of the methyltransferase that biosynthesizes this psychotogen.
L R, Mandel +3 more
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Dimethyltryptamin: ein neues Psychoticum
European Neurology, 1958A.S. Sai-Halász +2 more
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