Results 191 to 200 of about 7,495 (248)

Comparison of a placebo, N-dimethyltryptamine, and 6-hydroxy-N-dimethyltryptamine in man

Psychopharmacologia, 1963
1. Five human subjects received intramuscularly at weekly intervals a placebo and equal doses of 6-hydroxy-N-dimethyltryptamine (6-HDMT) and N-dimethyltryptamine (DMT) (1 mg/kg, 4 subjects; 0.75 mg/kg, 1 subject). 2. DMT produced markedly significant mental effects including anxiety, hallucinations, and perceptual distortions and ...
D E, ROSENBERG, H, ISBELL, E J, MINER
openaire   +2 more sources

Incilius alvarius Cell-Based Synthesis of 5-Methoxy-N,N-Dimethyltryptamine

Psychedelic Medicine, 2023
There is growing interest in the therapeutic potential of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) for psychiatric disorders. Although 5-MeO-DMT can be chemically synthesized, the parotoid gland secretions of Incilius alvarius (also known as the ...
Leonardo A. Lerer, E. Reynolds, J. Varia, K. Blakolmer, B. Lerer   +4 more
semanticscholar   +1 more source

Significance of mammalian N, N-dimethyltryptamine (DMT): A 60-year-old debate

Journal of Psychopharmacology, 2022
N,N-dimethyltryptamine (DMT) is a potent psychedelic naturally produced by many plants and animals, including humans. Whether or not DMT is significant to mammalian physiology, especially within the central nervous system, is a debate that started in the
Javier Hidalgo Jiménez, José Carlos Bouso   +1 more
semanticscholar   +1 more source

In vivo metabolism of 5-methoxy-N, N-dimethyltryptamine and N,N-dimethyltryptamine in the rat

Biochemical Pharmacology, 1987
Following intraperitoneal administration, 5-methoxy-N,N-dimethyltryptamine and N,N-dimethyltryptamine are subject to both a very rapid uptake into, and clearance from, all tissues examined. The current studies in vivo confirm previous in vitro observations that the routes involved in the metabolism of these compounds include oxidative deamination, N ...
B R, Sitaram, L, Lockett, R, Talomsin, G L, Blackman, W R, McLeod   +4 more
openaire   +2 more sources

A Dimethyltryptamine-Forming Enzyme in Human Blood

American Journal of Psychiatry, 1973
An enzyme capable of forming the hallucinogen dimethyltryptamine was found in human red blood cells, plasma, and platelets. The enzyme activity in red blood cells and plasma was not significantly different in psychiatric patients from that in normal subjects.
R J, Wyatt, J M, Saavedra, J, Axelrod
openaire   +2 more sources

Urinary Excretion of Dimethyltryptamine in Liver Disease

American Journal of Psychiatry, 1979
The urinary excretion of N,N-dimethyltryptamine (DMT) was higher in patients with severe liver disease than in normal subjects. This difference remained significant when patients with all grades of hepatic encephalopathy were excluded. Patients with liver disease whose mental states were normal excreted amounts of DMT similar to those of patients with ...
S A, Checkley, M C, Oon, R, Rodnight, M P, Murphy, R S, Williams, J L, Birley   +5 more
openaire   +2 more sources

Urinary dimethyltryptamine and psychiatric symptomatology and classification

Psychological Medicine, 1977
SynopsisThe excretion of dimethyltryptamine (DMT) was studied amongst 122 recently admitted psychiatric patients and 20 normal subjects. DMT was detected in the urine of 47% of those diagnosed by their psychiatrists as schizophrenic, 38% of those with other non-affective psychoses, 13% of those with affective psychoses, 19% of those with neurotic and ...
R, Rodnight, R M, Murray, M C, Oon, I F, Brockington, P, Nicholls, J L, Birley   +5 more
openaire   +2 more sources

N,N-dimethyltryptamine mitigates experimental stroke by stabilizing the blood-brain barrier and reducing neuroinflammation

Science Advances
N,N-dimethyltryptamine (DMT) is a psychoactive molecule present in the human brain. DMT is under clinical evaluation as a neuroprotective agent in poststroke recovery. Yet, its mechanism of action remains poorly understood.
M. Laszlo, Judit P. Vigh, Anna E Kocsis, G. Porkoláb, Z. Hoyk, T. Polgár, F. Walter, A. Szabó, S. Djurovic, B. Merkely, Alán Alpár, E. Frecska, Z. Nagy, M. Deli, S. Nardai   +14 more
semanticscholar   +1 more source

N,N-Dimethyltryptamine–Induced Psychosis

Clinical Neuropharmacology, 2015
N,N-dimethyltryptamine (DMT) is a 5-hydroxytryptamine 2A and 1A receptor agonist that exhibits potent psychoactive properties in humans. Recreational use of this drug has increased precipitously and is likely to result in an increase in patients presenting with substance-induced psychoses. The present case provides an early example of substance-induced
Neil E, Paterson, W Connor, Darby, Preetpal S, Sandhu   +2 more
openaire   +2 more sources

Prospective examination of synthetic 5-methoxy-N,N-dimethyltryptamine inhalation: effects on salivary IL-6, cortisol levels, affect, and non-judgment

Psychopharmacology, 2019
5-methoxy-N,N-dimethyltryptamine is a psychotropic substance found in various plant and animal species and is synthetically produced. 5-methoxy-N,N-dimethyltryptamine is used in naturalistic settings for spiritual exploration, recreation, or to address ...
Malin V Uthaug, Rafael Lancelotta, Attila Szabó   +2 more
exaly   +2 more sources