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Hydroxylation and N-demethylation of N,N-dimethyltryptamine

Experientia, 1959
Der intermediare Stoffwechsel des psychotropen N,N-Dimethyltryptamins wurde untersucht. N-Methyltryptamin, als Produkt der Demethylierung, und 6-Hydroxy-N,N-Dimethyltryptamin, als Produkt der Hydroxylierung, wurden nachgewiesen und papierchromatographisch charakterisiert.
S, SZARA, J, AXELROD
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The biosynthesis of dimethyltryptamine in vivo.

Research communications in chemical pathology and pharmacology, 1977
The in vivo formation of dimethyltryptamine was studied in rabbits, rats and monkeys. When C14-labelled N-methyltryptamine was administered by intravenous injection to rabbits, C14-dimethyltryptamine was found in lung, the principle site of the methyltransferase that biosynthesizes this psychotogen.
L R, Mandel   +3 more
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Neuromodulatory mechanisms of N,N-dimethyltryptamine

Brain Network and Modulation, 2023
N,N-dimethyltryptamine (DMT) is the simplest psychedelic tryptamine and is produced naturally by many plant and animal species, including humans. While classical psychedelics, such as lysergic acid diethylamide, or psilocybin, are gaining interest because of their therapeutic potential, DMT has yet to be fully investigated ...
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Dimethyltryptamine (DMT) a Psychedelic

2009
DMT, also known as N,N-dimethyltryptamine, is a naturally-occurring tryptamine and potent psychedelic drug, found not only in many plants, but also in trace amounts in the human body where its natural function is undetermined. Structurally, it is analogous to the neurotransmitter serotonin and other psychedelic tryptamines such as 5-MeO-DMT and 4-HO ...
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[Elimination of N,N-dimethyltryptamine by urine].

Acta psiquiatrica y psicologica de America latina, 1994
N,N-dimethiltryptamine (DMT) in urine has been quantified on an 83-psychiatric patient sample. Sample covered patients who had sometimes been administered neuroleptic drugs as well as patients with some particular symptomatology associated to psychotic disorders such as hallucinations, delusions, perception disorders, etc. 43.3% (36 cases) evidenced an
N, Spatz   +4 more
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The effect of antiserotonin on the experimental psychosis induced by dimethyltryptamine

Experientia, 1962
40 normale Personen bekamen DMT; der resultierende psychotische Zustand wurde beobachtet und registriert, 15 von diesen Versuchspersonen wiederholten das Experiment nach Verabreichung von Antiserotonin (UML-491). Das Antiserotonin hatte eine stark potenzierende Wirkung auf die experimentelle Psychose.
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N,N-Dimethyltryptamine: DMT-induced psychosis

The American Journal of Emergency Medicine, 2020
David, Barbic   +3 more
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