Results 91 to 100 of about 196 (117)

Dioscorin isolated from Dioscorea alata activates TLR4-signaling pathways and induces cytokine expression in macrophages

Biochemical and Biophysical Research Communications, 2006
The Toll-like receptor 4 (TLR4)-signaling pathway is crucial for activating both innate and adaptive immunity. TLR4 is a promising molecular target for immune-modulating drugs, and TLR4 agonists are of therapeutic potential for treating immune diseases and cancers.
Wen-Chi Hou, Shu-Ling Fu, Chao-Hsiung Lin   +2 more
exaly   +3 more sources

Molecular cloning, structural analysis and mass spectrometric identification of native dioscorins of various yam species

Journal of the Science of Food and Agriculture, 2012
AbstractBACKGROUND: Dioscorins are the major storage proteins of yam tubers. However, the molecular nature of their heterogeneity in tubers has not been fully elucidated. In this study the authors isolated the dioscorin gene families of Dioscorea japonica and Dioscorea pseudojaponica, performed matrix‐assisted laser desorption/ionisation time‐of‐flight
Wei-Yi, Tsai, Yi-Jyun, Jheng, Kuo-Hsuan, Chen, Kuo-Wei, Lin, Yen-Pen, Ho, Ching-Chi, Yang, Kuo-Chih, Lin   +6 more
openaire   +2 more sources

Recombinant dioscorins of the yam storage protein expressed in Escherichia coli exhibit antioxidant and immunomodulatory activities

Protein Expression and Purification, 2012
Dioscorins, the major storage proteins in yam tubers, exhibit biochemical and immunomodulatroy activities. To investigate the potential application of dioscorins in biomedical research, we expressed the dioscorin genes Dj-dioA3 and Dp-dioA2 from Dioscorea japonica and Dioscorea pseudojaponica, respectively, in E.
Yi-Jyun, Jheng, Wei-Yi, Tsai, Kuo-Hsuan, Chen, Kuo-Wei, Lin, Chia-Lin, Chyan, Ching-Chi, Yang, Kuo-Chih, Lin   +6 more
openaire   +2 more sources

Biosynthesis of dioscorine : Incorporation of nicotinic acid into the isoquinuclidine moiety

Phytochemistry, 1977
Abstract The administration of nicotinic-[2-14C] acid to Dioscorea hispida plants afforded radioactive dioscorine (1.9% absolute incorporation) and a systematic degradation of the alkaloid indicated that essentially all the activity was located at C-3. Dioscorine derived from nicotinic-[5,6-14C, 13C2] acid was also labelled.
openaire   +1 more source

Dioscorea alata tuber proteome analysis shows over thirty dioscorin isoforms and novel tuber proteins

Plant Physiology and Biochemistry, 2017
In Dioscorea, dioscorin (31 kDa) is the major storage protein constituting 85% of the total tuber proteins. An integrated proteomic and biochemical approach was used to understand the physiological role of dioscorin in the two contrasting growth stages (germinating and mature tuber).
Shruti, Sharma, Ravi, Gupta, Renu, Deswal   +2 more
openaire   +2 more sources

Development of Yam Dioscorin-Loaded Nanoparticles for Paracellular Transport Across Human Intestinal Caco-2 Cell Monolayers

Journal of Agricultural and Food Chemistry, 2018
Dioscorins, the major storage proteins of yam tubers, exert immunomodulatory activities. To improve oral bioavailability of dioscorins in the intestine, recombinant dioscorin (rDioscorin) was coated with N,N,N-trimethyl chitosan (TMC) and tripolyphosphate (TPP), resulting in the formation of TMC-rDio-TPP nanoparticles (NPs).
Kuo-Chih Lin, Chia-Hung Lee
exaly   +3 more sources

Antioxidative Ability, Dioscorin Stability, and the Quality of Yam Chips from Various Yam Species as Affected by Processing Method

Journal of Food Science, 2009
ABSTRACT:  The antioxidative ability, stability of storage protein dioscorin, and the quality of fried yam chips from different cultivars of Chinese yams influenced by various processing treatments were investigated.
Y-M, Liu, K-W, Lin
exaly   +3 more sources

Dioscorin Pre-treatment Protects A549 Human Airway Epithelial Cells from Hydrogen Peroxide-Induced Oxidative Stress

Inflammation, 2013
Hydrogen peroxide (H(2)O(2)) is a highly reactive oxygen species involved in lung and bronchial epithelium injury. Increased H(2)O(2) levels have been reported in expired breath condensates of patients with inflammatory airway diseases such as chronic obstructive pulmonary disease.
Jeng-Yuan Hsu, Chou Ming-Chih, Chen Ya-Wen   +2 more
exaly   +3 more sources

Investigating the impact of ultrasound on the structural, physicochemical, and emulsifying characteristics of Dioscorin: Insights from experimental data and molecular dynamics simulation

Food Chemistry
This study investigated the impact of ultrasound treatment on dioscorin, the primary storage protein found in yam tubers. Three key factors, namely ultrasound power, duration, and frequency, were focused on. The research revealed that ultrasound-induced cavitation effects disrupted non-covalent bonds, resulting in a reduction in α-helix and β-sheet ...
You-Lin Xue
exaly   +3 more sources

Yam Storage Protein Dioscorins from Dioscorea alata and Dioscorea japonica Exhibit Distinct Immunomodulatory Activities in Mice

Journal of Agricultural and Food Chemistry, 2009
The aim of this study was to elucidate the effect of the major storage protein dioscorin isolated from two different yam species, Tainong No. 1 (TN1-dioscorins) and Japanese yam (Dj-dioscorins), on the immune activities of mice. Dj-dioscorins, like TN1-dioscorins, could induce expression of the pro-inflammatory cytokines and stimulate phagocytosis of ...
Pei-Lan, Lin, Kuo-Wei, Lin, Ching-Feng, Weng, Kuo-Chih, Lin   +3 more
openaire   +2 more sources