Results 171 to 180 of about 5,720 (220)

Microbial modification of diosgenin and hecogenin

Journal of the Chemical Society, Perkin Transactions 1, 1973
On incubation with an unidentified bacterium diosgenin [(25R)-spirost-5-en-3β-ol](1) was converted into (25R)-9-oxode-AB-spirostane-8α-propionic acid (3). Incubation with Nocardia globerula produced the same oxo-acid (3) and also a small amount of its 1 7α-hydroxy-derivative.
R, Howe, R H, Moore, B S, Rao, D T, Gibson   +3 more
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The role of diosgenin in diabetes and diabetic complications

The Journal of Steroid Biochemistry and Molecular Biology, 2020
Diabetes mellitus is a chronic and common metabolic disease that seriously endangers human health. Hyperglycemia and long-term metabolic disorders in diabetes will cause damage to the whole body tissues and organs, resulting in serious complications. Nowadays, drugs for treating diabetes on the market has strong side effects, new treatments thus are ...
Qingxia, Gan, Jin, Wang, Ju, Hu, Guanhua, Lou, Haijun, Xiong, Chengyi, Peng, Song, Zheng, Qinwan, Huang   +7 more
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Cardiovascular Effect of Diosgenin in Ovariectomized Rats

Journal of Medicinal Food, 2019
Diosgenin is a phytoestrogen and a constituent of Dioscorea . It has several biological effects, and some of them are anti-inflammatory, antidiabetic, antitumor, and vasodilatory. The present study investigated both the vasorelaxing and antioxidant mechanisms of diosgenin in isolated rat ...
Ilmara Cecilia Pinheiro de Silva, Morais, Iris Jordânia Luz, Moura, Carla Kelly Barroso, Sabino, Lucas Antonio Duarte, Nicolau, Fabiana de Moura, Souza, José Couras da, Silva-Filho, Rita de Cássia Meneses, Oliveira, Jand Venes Rolim, Medeiros, Sidney Gonçalo de, Lima, Aldeidia Pereira de, Oliveira   +9 more
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Novel effects of diosgenin on skin aging

Steroids, 2009
Extracts of Dioscorea coomposita or Dioscorea villosa are consumed as supplemental health foods at the time of climacteric. The extracts contain large amounts of the plant steroid, diosgenin. Here, we studied the safety and efficacy of diosgenin against skin aging at the time of climacteric. In vitro, diosgenin enhanced DNA synthesis in a human 3D skin
Yayoi, Tada, Naoko, Kanda, Akinori, Haratake, Megumi, Tobiishi, Hideyo, Uchiwa, Shinichi, Watanabe   +5 more
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Isolation of diosgenin by microbiological hydrolysis of saponin

Archives of Biochemistry and Biophysics, 1955
Abstract By microbial hydrolysis the saponins in pulverized Dioscorea tuber have been cleaved into the component parts, diosgenin and the sugar moieties. In one case a derivative, Δ 4 -diosgenone, was isolated. Although a wide range of conditions may be used in this conversion, the simplest include a mixed culture fermentation of pulverized fresh ...
J W, ROTHROCK, T H, STOUDT, J D, GARBER
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Advances in the pharmacological activities and mechanisms of diosgenin

Chinese Journal of Natural Medicines, 2015
Diosgenin, a well-known steroid sapogenin derived from plants, has been used as a starting material for production of steroidal hormones. The present review will summarize published literature concerning pharmacological potential of diosgenin, and the underlying mechanisms of actions.
Yan, Chen, You-Mei, Tang, Su-Lan, Yu, Yu-Wei, Han, Jun-Ping, Kou, Bao-Lin, Liu, Bo-Yang, Yu   +6 more
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Investigation on the mechanisms for biotransformation of saponins to diosgenin

World Journal of Microbiology and Biotechnology, 2013
In order to improve the efficiency of biotransformation of saponins in Dioscorea zingiberensis to diosgenin, a new enzymatic model was developed to investigate the mechanism of the metabolic systems. Four main saponin hydrolases (E1, E2, E3 and E4) were purified from Trichoderma reesei.
Yuling, Zhu, Hancan, Zhu, Muqing, Qiu, Tingting, Zhu, Jinren, Ni   +4 more
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Effects of diosgenin and its derivatives on atherosclerosis

Food & Function, 2019
The effects of diosgenin are discussed with respect to endothelial dysfunction, lipid profile, macrophage foam cell formation, VSMC viability, thrombosis and inflammation during the formation of atherosclerosis.
Fang-Chun Wu, Jian-Guo Jiang
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Solubility of diosgenin in different solvents

The Journal of Chemical Thermodynamics, 2012
Abstract The solubility of diosgenin in methanol, ethanol (95%), isopropanol, acetone, acetic ether, and propyl acetate were measured at temperatures from (295.15 to 330.15) K using the synthetic method by a laser monitoring observation technique at atmospheric pressure.
Fei-xiong Chen, Ming-rui Zhao, Bao-zeng Ren, Cai-rong Zhou, Fei-fei Peng   +4 more
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Chemodifferentiation of diosgenin in Dioscorea composita

Phytochemistry, 1984
Abstract Diosgenin was isolated from different parts of a three-year-old plant of Dioscorea composite . The amounts (% on a dry wt basis) present were: tubers, 3.6; vine internodes and nodes with their leaves from first 20 nodes from the tubers, 1.6; similarly from intermediate 20 nodes, 0.039 and from upper 20 nodes, 0.03.
S.K. Datta, Karabi Datta
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