Results 211 to 220 of about 6,693 (273)

Engineering of the Flavone Rutinoside Biosynthetic Pathway Enables Production of Diosmin, a Venoactive Compound in Solanum lycopersicum and Nicotiana tabacum.

Plant Biotechnology Journal, EarlyView.
Diosmin is often used as a dietary supplement, and it is sometimes used to make phlebotropic drugs for venous diseases. Traditionally, diosmin is obtained by the dehydrogenation of the flavanone glycoside hesperidin through chemical semisynthesis.
Qianle Zhang, Qingwen Wu, Wenjing Shi, Yinai Deng, Ruoting Zhan, Dongming Ma   +5 more
semanticscholar   +2 more sources

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Diosmin: A potential natural drug

Global Journal of Basic Science
Diosmin is of potential interest for its possible role in human health. Diosmin is a flavone glycoside that is a member of the class of flavonoids, which are secondary metabolites found in large quantities in plants and vegetables.
A. Irshath
semanticscholar   +2 more sources

Diosmin/hesperidin

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semanticscholar   +4 more sources

Spectroscopic and structural studies of the diosmin monohydrate and anhydrous diosmin

International Journal of Pharmaceutics, 2017
Diosmin, a flavone glycoside frequently used in therapy of various veins diseases in monohydrate form, exhibits poor solubility in water and low bioavailability. Due to the fact that the anhydrous forms of drugs generally have better bioavailability than the corresponding hydrates, the aim of this study was to analyze the conversion of diosmin ...
Łukasz, Szeleszczuk, Dariusz Maciej, Pisklak, Monika, Zielińska-Pisklak, Iwona, Wawer   +3 more
openaire   +2 more sources

Diosmin pretreatment affects bioavailability of metronidazole

European Journal of Clinical Pharmacology, 2003
To screen for inhibitory effects of diosmin on cytochrome P(450)-mediated metabolism of metronidazole in healthy volunteers.Before/after non-blinded investigation conducted in healthy male volunteers.After an overnight fast, metronidazole (two 400-mg tablets) was administered to 12 volunteers, either alone or after a 9-day pretreatment period with a ...
K, Rajnarayana, Mada S, Reddy, Devarakonda R, Krishna   +2 more
openaire   +2 more sources

Reno-protective impact of diosmin and perindopril in amikacin-induced nephrotoxicity rat model: modulation of SIRT1/p53/C-FOS, NF-κB-p65, and keap-1/Nrf2/HO-1 signaling pathways

Immunopharmacology and immunotoxicology
Purpose Amikacin (AMC), an aminoglycoside antibiotic known for its rapid and potent bactericidal activity, is also associated with nephrotoxicity. Diosmin and perindopril have been reported to improve renal function and hold promise as therapeutic agents
Nashwa Abdelaala, Ehab A. M. El-Shoura, M. Khalaf, Dalia Zafaar, Ahmed A N Ahmed, A. Atwa, BaselA Abdel-Wahab, YasmineH Ahmed, Ahmed Abomandour, E. A. Salem   +9 more
semanticscholar   +1 more source

Diosmin as Antidiabetic Agent: A Comprehensive Mechanistic Approach

Current Bioactive Compounds
Diabetes mellitus is a chronic metabolic disorder which occurs due to deficiency of insulin or resistance to insulin receptor. There are naturally occurring compounds found in various plants, foods, and herbs that have potent anti-diabetic properties ...
Uma Jyoti, Sushma Devi
semanticscholar   +1 more source

Diosmin for the prevention of ovarian hyperstimulation syndrome

International Journal of Gynecology & Obstetrics, 2020
AbstractObjectiveTo evaluate the effect of oral diosmin on the incidence and severity of ovarian hyperstimulation syndrome (OHSS) and explore the value of diosmin in preventing and treating OHSS.MethodA retrospective study of women attending a reproductive center in Guangzhou, China, between September and December 2016.
Tingting, Li, Wanshan, Zhu, Guihua, Liu, Cong, Fang, Song, Quan   +4 more
openaire   +2 more sources

The Effectiveness of Hesperidin, Diosmin and Proanthocyanidins Nutritional Supplementation on Cognitive and Motor Functions in Older Adults: A Pilot Randomized Control Study.

Journal of the American Nutrition Association
BACKGROUND Frailty, falls, and disability are related to aging, which involves a decline in biological function. Proper nutrition can reduce frailty. When consumed in significant quantities, phytochemical compounds carry out a variety of biological tasks.
Silvia Giovannini, Alessandra Lauria, Anna Maria Malizia, Elisabetta Lama, Nadia Morciano, L. Biscotti, C. Loreti, Letizia Castelli   +7 more
semanticscholar   +1 more source

Diosmin-containing phlebotropic drugs in varicose eczema

Angiology and vascular surgery, 2019
The purpose of the study was to examine the effect of diosmine-based phlebotropic drugs on dynamics of regress of varicose eczema in patients with chronic venous diseases, to compare their objective complaints and subjective symptoms before and after treatment, to determine the time of improvement.The study enrolled a total of 80 patients presenting ...
D V, Rodnyansky, A A, Fokin
openaire   +2 more sources