Results 11 to 20 of about 76,953 (277)

Casting a wide net: use of diverse model organisms to advance toxicology [PDF]

, 2020
© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Hahn, M. E., & Sadler, K. C. Casting a wide net: use of diverse model organisms to advance toxicology.
Hahn, Mark E., Sadler, Kirsten C.
core   +1 more source

Poland Syndrome With Dextrocardia: A Rare Association Leading to Complex Cardiopulmonary Challenges. [PDF]

Clin Case Rep
ABSTRACT Patients with Poland syndrome, especially those with left‐sided defects accompanied by dextrocardia, may be predisposed to significant respiratory and cardiac complications. This case underscores the importance of early recognition, thorough cardiopulmonary assessment, and proactive planning for airway management and ventilatory support to ...
Kommineni S, Morse A, Jekkireddy S, Ganti S, Gaddam M.   +4 more
europepmc   +2 more sources

Correlating biodegradation kinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin to the dynamics of microbial communities originating from soil in Vietnam contaminated with herbicides and dioxins

Frontiers in Microbiology, 2022
We studied the succession of bacterial communities during the biodegradation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD). The communities originated from a mesocosm with soil from Bien Hoa airbase in Vietnam heavily contaminated with herbicides
Thi Lan Anh Nguyen, Thi Lan Anh Nguyen, Ha Thi Cam Dang, Ton That Huu Dat, Bernd W. Brandt, Wilfred F. M. Röling, Abraham Brouwer, Abraham Brouwer, Rob J. M. van Spanning   +8 more
doaj   +1 more source

NAD+ loss, a new player in AhR biology: prevention of thymus atrophy and hepatosteatosis by NAD+ repletion

Scientific Reports, 2017
Dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD) is a carcinogenic and highly toxic industrial byproduct that persists in the environment and produces a pleiotropic toxicity syndrome across vertebrate species that includes wasting, hepatosteatosis, and
Silvia Diani-Moore, Jenny Shoots, Rubi Singh, Joshua B. Zuk, Arleen B. Rifkind   +4 more
doaj   +1 more source

Genetic Control of MAP3K1 in Eye Development and Sex Differentiation

Cells, 2021
The MAP3K1 is responsible for transmitting signals to activate specific MAP2K-MAPK cascades. Following the initial biochemical characterization, genetic mouse models have taken center stage to elucidate how MAP3K1 regulates biological functions.
Jingjing Wang, Eiki Kimura, Maureen Mongan, Ying Xia   +3 more
doaj   +1 more source

Effects of Dioxin on DNA Damage in the Testes of Adult Male Mice

Pharmaceutical and Biomedical Research, 2023
Background: Given the importance of environmental factors and the impact of environmental pollutants, such as dioxins, on organ systems, especially the reproductive system, it is necessary to study these issues and the mechanisms of their effects ...
Shabnam Mohammadi, Narjes Jalilvand, Fatemeh Esfandiari, Seyed Saleh Attari   +3 more
doaj  

Mechanistic insight into the effects of Aryl Hydrocarbon Receptor activation on osteogenic differentiation

Bone Reports, 2017
While inhibition of bone healing and increased rates of pseudarthrosis are known adverse outcomes associated with cigarette smoking, the underlying mechanisms by which this occurs are not well understood.
Chawon Yun, Joseph A. Weiner, Danielle S. Chun, Jonghwa Yun, Ralph W. Cook, Michael S. Schallmo, Abhishek S. Kannan, Sean M. Mitchell, Ryan D. Freshman, Christian Park, Wellington K. Hsu, Erin L. Hsu   +11 more
doaj   +1 more source

Flavin-Containing Monooxygenase 3 (FMO3) Is Critical for Dioxin-Induced Reorganization of the Gut Microbiome and Host Insulin Sensitivity

Metabolites, 2022
Exposure to some environmental pollutants can have potent endocrine-disrupting effects, thereby promoting hormone imbalance and cardiometabolic diseases such as non-alcoholic fatty liver disease (NAFLD), diabetes, and cardiorenal diseases.
William Massey, Lucas J. Osborn, Rakhee Banerjee, Anthony Horak, Kevin K. Fung, Danny Orabi, E. Ricky Chan, Naseer Sangwan, Zeneng Wang, J. Mark Brown   +9 more
doaj   +1 more source

Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context [PDF]

, 2012
The aryl hydrocarbon receptor (AhR) mediates the induction of a variety of xenobiotic metabolism genes. Activation of the AhR occurs through binding to a group of structurally diverse compounds, most notably dioxins, which are exogenous ligands ...
BALBONI, GIANFRANCO, Bell DR, CONGIU, CENZO, Denison MS, Fernandes A, He G, Mellor I.R., ONNIS, VALENTINA, Rose M, Rowlands JC, Wall RJ   +10 more
core   +1 more source

Dioxins levels in human blood after implementation of measures against dioxin exposure in Japan

Environmental Health and Preventive Medicine, 2019
Background Over the past few decades, the Japanese Ministry of the Environment has been biomonitoring dioxins in the general Japanese population and, in response to public concerns, has taken measures to reduce dioxin exposure.
Basilua Andre Muzembo, Miyuki Iwai-shimada, Tomohiko Isobe, Kokichi Arisawa, Masayuki Shima, Tetsuhito Fukushima, Shoji F. Nakayama   +6 more
doaj   +1 more source