Results 11 to 20 of about 933 (135)

Facile Conversion of o-Quinones into 1,3-Dioxoles [PDF]

Organic Letters, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Belen, Batanero, Fructuoso, Barba
openaire   +2 more sources

Aza‐Büchner–Curtius–Schlotterbeck Reaction Enables Selective Construction of Quaternary Carbon Centers

Angewandte Chemie International Edition, EarlyView.
We introduce the Aza‐Büchner–Curtius–Schlotterbeck (ABCS) reaction: A mild, catalyst‐free method for homologating aryl imines. Diverging from the traditional BCS mechanism, the diazo intermediate undergoes selective C─C insertion to form an all‐carbon quaternary center.
Simon O. Angerer, Vincent George, Aryaman Pattanik, Gaia Carpentiero, Tereza Morcinková, Julia Rehbein, Burkhard König   +6 more
wiley   +1 more source

Discrepancy in Reported and Observed Monoacylglycerol Lipase Inhibition of Aryl Formyl Piperidine Containing Potent and Highly Selective Monoacylglycerol Lipase Inhibitor

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A reported potent and selective reversible MAGL inhibitor fails to reproduce its claimed potency in two established in vitro assays, even when the previously reported substrate is used, while eight related analogs are likewise inactive. The findings highlight substantial assay‐dependent behavior and the need for careful validation before such compounds
Juha R. Savinainen, Praveen Kumar Singh, Jari Yli‐Kauhaluoma, Jayendra Z. Patel   +3 more
wiley   +1 more source

Chlorothiophene‐Substituted N‐Phenylpyrazolines: Synthesis, Anticancer Evaluation, and Computational Insight into COX‐2 Inhibition

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Eight novel N‐phenylpyrazoline derivatives bearing chlorothiophene moieties were synthesized and evaluated for anticancer activity against T47D, MCF7, and WiDr cell lines. Compound 2g showed the strongest cytotoxicity against WiDr cells (IC50 = 19.63 µg/mL) with the highest selectivity index (665.88), highlighting its potential as a selective ...
Nikma Farismatur Riza, Fia Fathiana Wulan, Tegar Asanda Ghifari, Endang Astuti, Tutik Dwi Wahyuningsih   +4 more
wiley   +1 more source

The Mycorrhizal Fungal Species Funneliformis mosseae Reshapes Rhizosphere Microbial Metabolic Pathways of Soybeans Under Tetracycline Stress

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
The presence of residual antibiotics (tetracycline) poses a threat to food safety in the black soils of northeastern China and a mycorrhizal fungal species Funneliformis mosseae could mitigate the negative effects. This study tracked the changes in soybeans' rhizospheric microbial profiles and the associated metabolites during the bioremediation ...
Chao Yang, Baiyan Cai, Harry Lye Hin Chong, Juan Li, Linghui Li, Jean Wan Hong Yong, Khim Phin Chong   +6 more
wiley   +1 more source

Heterocyclic‐Based Fungicides: Emerging Strategies for Viable Plant Disease Control

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Heterocyclic compounds have attracted considerable attention because of their structural diversity, potent antifungal activity, and ability to interact with multiple fungal targets, offering broad‐spectrum protection against phytopathogens. Synthetic and semisynthetic/part‐natural scaffolds, particularly azole, quinoline, indole, cyclotryptamine, and ...
Sumit Tahlan, Meenakshi Kaira, Sucheta Singh, Hrithik Dey, Kailash C. Pandey   +4 more
wiley   +1 more source

New Polymeric Binders for the Preparation and Optimization of Pt/C‐Based Electrodes for Proton‐Exchange Membrane Fuel Cells (PEMFCs)

ChemElectroChem, Volume 13, Issue 16, 18 August 2026.
This study optimizes PEMFC catalyst layers (CLs) by comparing short‐side‐chain N+125D and high‐oxygen‐permeability EIG ionomers. By analyzing ionomer–solvent interactions in water/1‐propanol mixtures through advanced physical–chemical characterization, the research ensures ink stability and homogeneous electrocatalyst distribution.
Christian Dall’Occo, Piercarlo Mustarelli, Alberto Marelli, Daniele Facchi, Carlo Santoro, Lucia Mazzapioda   +5 more
wiley   +1 more source

Lead‐Free Chiral Hybrid Metal Halides for Circularly Polarized Light‐Emitting Diodes

Advanced Optical Materials, Volume 14, Issue 30, 14 August 2026.
Lead‐free chiral hybrid metal halides provide a versatile platform for realizing chiroptical responses through chiral modulation of metal–halide frameworks with diverse dimensionalities, induces inversion‐symmetry breaking and enables dissymmetric excited‐state transitions toward efficient circularly polarized luminescence and electroluminescence. This
Kun Zhu, Li Wan
wiley   +1 more source

Selenium‐Containing 1,4‐Naphthoquinone Derivatives Trigger Reactive Oxygen Species and Apoptosis in Triple‐Negative Breast Cancer Cells

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Cancer ranks as a leading cause of death worldwide, demanding new affordable therapies. Nature offers a diverse array of bioactive scaffolds, including 1,4‐naphthoquinone, which serves as a precursor for numerous natural and synthetic compounds with potent antitumor properties.
Eduardo Angulo‐Elizari, Asif Raza, Hannah Johnson, Nuria Martínez‐Sáez, Ignacio Encío, Arun K. Sharma, Carmen Sanmartín, Daniel Plano   +7 more
wiley   +1 more source

Integrative Insights Into DYRK1A From Molecular Function to Therapeutic Advancement

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
At the center the 3D structure of DYRK1A has been displayed. The dual‐function of DYRK1A involved in cancer and neurodegeneration, i.e., its overexpression drives Down syndrome, neurodegenerative disease etc., and underexpression causes intellectual disability, seizures, etc.
Sampriti Paul, Sonal Dubey, Prashant Tiwari   +2 more
wiley   +1 more source