Results 11 to 20 of about 923 (130)

Lead‐Free Chiral Hybrid Metal Halides for Circularly Polarized Light‐Emitting Diodes

open access: yesAdvanced Optical Materials, Volume 14, Issue 30, 14 August 2026.
Lead‐free chiral hybrid metal halides provide a versatile platform for realizing chiroptical responses through chiral modulation of metal–halide frameworks with diverse dimensionalities, induces inversion‐symmetry breaking and enables dissymmetric excited‐state transitions toward efficient circularly polarized luminescence and electroluminescence. This
Kun Zhu, Li Wan
wiley   +1 more source

Selenium‐Containing 1,4‐Naphthoquinone Derivatives Trigger Reactive Oxygen Species and Apoptosis in Triple‐Negative Breast Cancer Cells

open access: yesDrug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT Cancer ranks as a leading cause of death worldwide, demanding new affordable therapies. Nature offers a diverse array of bioactive scaffolds, including 1,4‐naphthoquinone, which serves as a precursor for numerous natural and synthetic compounds with potent antitumor properties.
Eduardo Angulo‐Elizari   +7 more
wiley   +1 more source

Integrative Insights Into DYRK1A From Molecular Function to Therapeutic Advancement

open access: yesChemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
At the center the 3D structure of DYRK1A has been displayed. The dual‐function of DYRK1A involved in cancer and neurodegeneration, i.e., its overexpression drives Down syndrome, neurodegenerative disease etc., and underexpression causes intellectual disability, seizures, etc.
Sampriti Paul   +2 more
wiley   +1 more source

Nanoporous Microelectrodes for Neural Electrophysiology Recordings in Organotypic Culture

open access: yesAdvanced Materials Technologies, Volume 11, Issue 7, 6 April 2026.
The highly porous microelectrodes have been designed and printed on culture membranes, allowing to record electrophysiological neural activity for rodent brain slices. To keep the biocompatible nanoporous structure, the microelectrodes and insulative layer are fabricated on the bottom of culture membranes with only small connector pads added on the top.
Petro Lutsyk   +3 more
wiley   +1 more source

Substitutive Approach Toward Heteroaromatic Amino Alcohols Accessed Through Dioxolanyl Radical Linchpin

open access: yesAdvanced Synthesis &Catalysis, Volume 368, Issue 7, 1 April 2026.
A dioxolanyl linchpin has been used to synthesize aryl ethanolamines from readily available aryl bromide and amine starting materials using a metallaphotoredox/substitution telescoped sequence. This combinatorial approach allows for a wide synthetic scope of both heteroarenes and cyclic amines. Aryl ethanolamines are an important functional group found
Justin J. Chang   +4 more
wiley   +1 more source

Structure‐Guided Optimization and Biological Validation of 1,3,4‐Thiadiazole‐Based SIRT2 Inhibitors Reinforcing Channel Entrance Interactions

open access: yesDrug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT SIRT2, the cytoplasmic member of the sirtuin family, is generally acknowledged to promote cancer and contribute to the progression of various pathologies, including neurodegeneration, inflammation, obesity, and bacterial infection through the deacetylation of target substrates.
Ahmet Bugra Aksel   +9 more
wiley   +1 more source

Indole‐Based π‐Extended Monophosphine Ligands for Enhanced Palladium‐Catalyzed Sonogashira Coupling

open access: yesJournal of Heterocyclic Chemistry, Volume 63, Issue 4, Page 727-737, April 2026.
A general palladium‐catalyzed Sonogashira cross‐coupling of (hetero)aryl chlorides with aliphatic, (hetero)aryl alkynes is described using Pd(dba)₂/PCy2‐Napdole‐phos catalyst system. The reaction protocol exhibits broad substrate scope and the catalyst loading can be down to 0.2 mol% Pd.
Yu Kiu Lau   +9 more
wiley   +1 more source

Enhanced Scintillation with Uncorrelated TL and OSL Signals in LiCaAlF6:Eu Nanoparticles Enables Unprecedented Multimodal Radiation Dosimetry

open access: yesAdvanced Optical Materials, Volume 14, Issue 7, 16 February 2026.
The graphical abstract illustrates the coexistence of independent OSL and TL signals, demonstrating that the material preserves TL information even after complete OSL zeroing, enabling a dual dosimetric readout within the same material. Abstract The development of multimodal dosimeters capable of preserving independent luminescent signals is a ...
Nancy Gabriela Chicango Arcos   +3 more
wiley   +1 more source

Luminescent Chiral Molecular Glasses by Melt‐Quenching Enantiopure BINAP

open access: yesAdvanced Science, Volume 13, Issue 8, 9 February 2026.
Melt‐quenching of enantiopure BINAP yields transparent chiral molecular glasses that retain axial chirality and display blue‐shifted luminescence together with strongly enhanced circularly polarized emission with dissymmetry factors |glum| of ≈10−2.
Nuttaporn Krittametaporn   +8 more
wiley   +1 more source

Quantifying the Electrophilicity of 9(10H)‐Phenanthrenone‐ and 1‐Acenaphthenone‐Derived α, β‐Unsaturated Ketones

open access: yesJournal of Physical Organic Chemistry, Volume 39, Issue 2, February 2026.
The electrophilicities (Mayr E) of the α, β‐unsaturated ketones A and B were determined by kinetic studies of their reactions with carbanions (reference nucleophiles) in DMSO at 20°C. The different reactivities of A and B were rationalized by DFT calculations.
Christoph Gross   +5 more
wiley   +1 more source

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