Results 31 to 40 of about 1,795 (189)

Halodifluoromethyl Moieties as Unconventional Halogen Bond Donors in Drug Discovery and Peptide Design [PDF]

, 2023
Die in Arzneistoffen (engl. active pharmaceutical ingredients, APIs) enthaltenen Halogene Chlor, Brom und Iod (X = Cl, Br, I) sind üblicherweise kovalent an sp2-hybridisierten, aromatischen Systemen (C(sp2)-X) gebunden.
Vaas, Sebastian
core   +1 more source

Luminescent Chiral Molecular Glasses by Melt‐Quenching Enantiopure BINAP

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Melt‐quenching of enantiopure BINAP yields transparent chiral molecular glasses that retain axial chirality and display blue‐shifted luminescence together with strongly enhanced circularly polarized emission with dissymmetry factors |glum| of ≈10−2.
Nuttaporn Krittametaporn, Philipp Ralle, Dorothea Dierks, Christian Nelle, Suresh K. Vasa, Pascal Kolodzeiski, Rasmus Linser, Andreas Steffen, Sebastian Henke   +8 more
wiley   +1 more source

4-(Bromomethyl)-1,3-dioxol-2-one

Acta Crystallographica Section E Crystallographic Communications, 2014
[80715-25-9] C4H3BrO3 (MW 178.97) 1S/C4H3BrO3/c5-1-3-2-7-4(6)8-3/h2H,1H2 InChIKey = KFZJRSPXJHVSCX-UHFFFAOYSA-N (highly functionalized/oxygenated reagent for allylation of carbonyl compounds; synthetic equivalent of 1-hydroxyacetone enolate; synthetic equivalent of a hydroxyacetophenone enolate; alkylating agent ...
Radomir N. Saicic, Veselin Maslak
openaire   +4 more sources

Síntesis de éteres derivados del Glicerol [PDF]

, 2022
El objetivo principal de este trabajo consiste en la síntesis de éteres derivados de ácidos grasos introducidos en el Solketal. Para la inserción de estos ácidos grasos cómo éteres se llevarán a cabo sucesivas síntesis de Williamson en las que se ...
Herrero Arrasate, Daniel
core  

Quantifying the Electrophilicity of 9(10H)‐Phenanthrenone‐ and 1‐Acenaphthenone‐Derived α, β‐Unsaturated Ketones

Journal of Physical Organic Chemistry, Volume 39, Issue 2, February 2026.
The electrophilicities (Mayr E) of the α, β‐unsaturated ketones A and B were determined by kinetic studies of their reactions with carbanions (reference nucleophiles) in DMSO at 20°C. The different reactivities of A and B were rationalized by DFT calculations.
Christoph Gross, Jan Brossette, Luc Schellmann, Peter Mayer, Hendrik Zipse, Armin R. Ofial   +5 more
wiley   +1 more source

A Versatile Materials Class for Solution‐Processed Optics and Photonics Based On Titanium Oxide Hydrates and Polyalcohols: A Perspective

Advanced Materials, Volume 38, Issue 3, 13 January 2026.
A new, solution‐processable class of optical materials based on molecular hybrids of metal oxide hydrates and commodity polymers is discussed here, including their synthesis, processing into thin films, patterning, and photonic structures realized to date.
Victoria Quirós‐Cordero, Alex H. Balzer, Stefan Bachevillier, Nissa Watkins, António Fernandes Ferreira, Joseph Mushyakov, Mehul Dhoot, Carlos Silva‐Acuña, Paul N. Stavrinou, Natalie Stingelin   +9 more
wiley   +1 more source

Functionalization of 6-Nitrobenzo[1,3]dioxole with Carbonyl Compounds via TDAE methodology [PDF]

Molecules, 2005
We report herein the synthesis of substituted 2-(6-nitrobenzo[1,3]dioxol-5-yl)-1- aryl ethanols and 2-(6-nitrobenzo[1,3]dioxol-5-yl)-propionic acid ethyl esters from the reaction of 5-chloromethyl-6-nitrobenzo[1,3]dioxole with various aromatic carbonyl and α- carbonyl ester derivatives using the tetrakis(dimethylamino)ethylene (TDAE) methodology.
Amiri-Attou, Ouassila, Terme, Thierry, Vanelle, Patrice   +2 more
openaire   +4 more sources

Small‐Molecule Sarco/Endoplasmic Reticulum Ca2+‐ATPase Activators Reverse Methylglyoxal‐Induced Inhibition through Nonantioxidant Mechanisms

ChemMedChem, Volume 21, Issue 1, January 2026.
Endoplasmic reticulum (ER) Ca2+ dysregulation drives β‐cell dysfunction under diabetic stressors like methylglyoxal, which inhibits the sarco/endoplasmic reticulum Ca2+‐ATPase (SERCA) pump through oxidative modifications. We show that synthetic SERCA activators restore pump activity after methylglyoxal‐induced damage.
Carlos Cruz‐Cortés, Silvia Micháliková, Petronela Rezbáriková, L. Michel Espinoza‐Fonseca, Jana Viskupičová   +4 more
wiley   +1 more source

Allylation of C(sp3)─H Bonds Using a MW/Persulfate Protocol

Helvetica Chimica Acta, Volume 109, Issue 1, January 2026.
The C(sp3)─H allylation using allyl phenyl sulfone was affected by persulfate anion (PS) under microwave (MW) irradiation. The MW/PS protocol proved applicable to a wide range of C(sp3)–H bonds in ethers, alkanes, aldehydes, and ketones, affording the corresponding C(sp3)–H allylated products.
Hsin‐Hsuan Lee, Chun‐Yu Chen, Yen‐Ku Wu, Ilhyong Ryu   +3 more
wiley   +1 more source

Synthesis of C-1 Homologues of Narciclasine [PDF]

, 2022
This thesis describes current progress towards the total synthesis of C1-homologues of the Amaryllidaceae alkaloid narciclasine (1), a powerful anticancer agent which suffers from a poor solubility profile. A 15-step chemoenzymatic total synthesis of C-1
Habaz, Lihi
core   +1 more source