Results 21 to 30 of about 887 (120)

Nanodroplet‐Array‐Plattform zur integrierten Synthese und Screening von MEK Inhibitoren: Ein miniaturisierter Ansatz für die frühe Pharmaforschung

Angewandte Chemie, Volume 137, Issue 48, November 24, 2025.
Wir präsentieren eine Nanodroplet‐Array‐Plattform, die die Integration von Festphasensynthese, MALDI‐MS‐Analyse und zellbasiertem Screening von 325 potenziellen MEK‐Inhibitoren (Mitogen‐aktivierte‐Proteinkinase‐Kinase) in Nanoliter‐Volumina ermöglicht.
Maximilian Seifermann, Julius Höpfner, Liana Bauer, Divya Varadharajan, Stefan Schmidt, Björn Fröhlich, Benjamin Wellenhofer, Charlotte Luchena, Carsten Hopf, Anna A. Popova, Pavel A. Levkin   +10 more
wiley   +1 more source

Direct Carboboration of Aryl Alkenes with Stable Organoborons Through Ziegler‐Type Addition

Advanced Science, Volume 12, Issue 43, November 20, 2025.
The direct carboboration of vinyl arenes with benzylic boronates has been achieved using KOtBu as the catalyst. Vinylcyclopropanes and vinylcyclobutane also participate in this reaction, yielding the corresponding 1,5‐ and 1,6‐carboboration products.
Mo Yang, Shengda Chen, Daojing Li, Liuzhou Gao, Guoqiang Wang, Shuhua Li   +5 more
wiley   +1 more source

Boosting the Charge Output of Enclosed Liquid‐Based Nanogenerators by Electrowetting‐Assisted Charge Injection Approach

Advanced Science, Volume 12, Issue 38, October 13, 2025.
The study introduces an electrowetting‐assisted charge injection (EWCI) approach to significantly enhance the charge density of enclosed liquid‐based nanogenerators (EW‐NGs). By leveraging EWCI, the volumetric output charge density reaches 19.1 mC m⁻3, a ninefold improvement over the conventional methods. Successfully powering a 10‐inch LCD screen, the
Ye Zhao, Leiyang Wang, Guo Li, Chenlu Rao, Yuqi Pan, Borong Chen, Haihong Xu, Frieder Mugele, Hao Wu   +8 more
wiley   +1 more source

Radikalische C─H‐Aroylierung von Allenen mittels kooperativer Photoredox‐ und N‐heterozyklischer Carben‐Katalyse

Angewandte Chemie, Volume 137, Issue 37, September 8, 2025.
Eine kooperative N‐heterozyklische Carben und Photoredox‐Katalyse zur C−H Benzoylierung und Veresterung von Allenen wird präsentiert. Diese Reaktion verläuft über die Kreuzkupplung von in situ generierten Ketyl‐ und Allylradikalen. Zusammenfassung Diese Studie demonstriert die Verwendung von kooperativer Photoredox‐ und N‐heterozyklischer Carben (NHC ...
Shyam Kumar Banjare, Lena Lezius, Armido Studer   +2 more
wiley   +1 more source

Radical C─H‐Aroylation of Allenes via Cooperative Photoredox and N‐Heterocyclic Carbene Catalysis

Angewandte Chemie International Edition, Volume 64, Issue 37, September 8, 2025.
Cooperative N‐heterocyclic carbene and photoredox catalysis for C─H benzoylation and esterification of allenes is presented. This reaction proceeds through the cross‐coupling of in situ generated ketyl and allyl radicals. Abstract This study demonstrates the use of cooperative photoredox and N‐heterocyclic carbene (NHC) catalysis for sp2 C─H acylation ...
Shyam Kumar Banjare, Lena Lezius, Armido Studer   +2 more
wiley   +1 more source

Inhibition of the Clathrin Terminal Domain—Amphiphysin Protein–Protein Interaction. Probing the Pitstop 2 Aromatic Moiety

ChemMedChem, Volume 20, Issue 16, August 16, 2025.
Pitstop 2 binds to the clathrin terminal domain. This work explores the nature of the benzylidene moiety, R. The synthesis of 56 novel analogues reveals enhanced potency of a multiple analogues, with catechol‐free 2,3‐dihydroxybenzo[b][1,4]dioxone (54) returning a 1.2 μm IC50, ca 10‐fold more active than Pitstop 2. Pitstop 2, (Z)‐N‐(5‐(4‐bromenzylidene)
Kate Prichard, Mark J. Robertson, Ngoc Chau, Jing Xue, Martin Neuenschwander, Uwe Fink, Andre Horatscheck, Marc Nazare, Phillip J. Robinson, Volker Haucke, Adam McCluskey   +10 more
wiley   +1 more source

A Solution‐Based Deposition Method Enabling Pigment Blue Edible Electrochemical Transistors

Advanced Science, Volume 12, Issue 29, August 7, 2025.
A novel solution‐based method is presented to produce Copper Phthalocyanine fibrous films displaying effective ion permeability and enhanced transconductance in electrolyte‐gated transistors architectures. Using these films, the first instance of a fully edible electrolyte‐gated transistor with volumetric capacitance, targeting in‐body applications, is
Alessandro Luzio, Fabrizio M. Ferrarese, Matteo Butti, Alberto D. Scaccabarozzi, Bojan Petrović, Sanja Kojić, Goran Stojanović, Simone Fiorini Granieri, Shubham Tanwar, Adrica Kyndiah, Mario Caironi   +10 more
wiley   +1 more source

Diglycerides of Natural Phenols and Organic Acids for Enhanced Biological Activities

Asian Journal of Organic Chemistry, Volume 14, Issue 8, August 2025.
Diglycerides of natural organic acids and phenols were synthesized regio‐selectively. Diglycerides are structurally similar to cell membranes and are expected to exhibit cell affinity and permeability. The flexible glycerol linkers allow the diglycerides to exhibit not only the physiological activities of each constituent organic acid but also the ...
Jisu Hong, Seunghyo Han, Huisu Yeo, Chanyoung Boo, Hyein Kim, Eunbi Kim, Boram Lim, Yeon Jeong Jo, Ji‐Seon Hyun, Nam Ho Lee, Sangho Koo   +10 more
wiley   +1 more source

Comparative Mass Spectroscopy Profiling of Masala Spices: Unveiling Direct and Remote Antimicrobial Effects of Nonvolatile and Aroma Metabolites via Biochemometric Tools and Molecular Networking

Food Frontiers, Volume 6, Issue 4, Page 1926-1953, July 2025.
Four major masala spices, Chaat, Pav Bhaji, Sambhar, and Tandoori, were analyzed using advanced multiplex mass spectrometry techniques. A total of 45 aroma compounds and 98 secondary metabolites were identified. These findings underscore the potential of masala spices not only as flavoring agents but also as potential food additives with antimicrobial ...
Mai E. Hussein, Mostafa H. Baky, Radwa H. El‐Akad, Mariam Hassan, Rupesh Deshmuk, Mohamed A. Farag   +5 more
wiley   +1 more source

Sesamin alleviates androgenetic alopecia by targeting the AR MAPK Wnt axis. [PDF]

Sci Rep
Li Y, Chen J, Xi R, Tang Q, Gao T, Qian Y, Huang Z, Ding B, Cao Y.   +8 more
europepmc   +1 more source