Results 1 to 10 of about 2,056 (169)

Carnosine Dipeptidase(Cndp): An emerging therapeutic target for metabolic diseases and cancers [PDF]

open access: diamondGenes and Diseases
Metabolic diseases, associated with high morbidity and mortality rates, pose a challenge to global public health and a significant burden on society.
Liang Zhou   +4 more
doaj   +3 more sources

Bioinformatics of cyanophycin metabolism genes and characterization of promiscuous isoaspartyl dipeptidases that catalyze the final step of cyanophycin degradation [PDF]

open access: yesScientific Reports, 2023
Cyanophycin is a bacterial biopolymer used for storage of fixed nitrogen. It is composed of a backbone of L-aspartate residues with L-arginines attached to each of their side chains.
Itai Sharon, T. Martin Schmeing
doaj   +2 more sources

The Enzyme Gene Expression of Protein Utilization and Metabolism by Lactobacillus helveticus CICC 22171 [PDF]

open access: yesMicroorganisms, 2022
The purpose of this study was to explore the hydrolytic ability of Lactobacillus helveticus CICC 22171 with regard to protein and the expression of enzyme genes during protein utilization. The results revealed that the strain hydrolyzed casein from the C-
Huixin Zhang   +4 more
doaj   +2 more sources

Multi-omics & pathway analysis identify potential roles for tumor N-acetyl aspartate accumulation in murine models of castration-resistant prostate cancer

open access: yesiScience, 2022
Summary: Castration-resistant prostate cancer (CRPC) is incurable and remains a significant worldwide challenge (Oakes and Papa, 2015). Matched untargeted multi-level omic datasets may reveal biological changes driving CRPC, identifying novel biomarkers ...
Mark J. Salji   +10 more
doaj   +1 more source

Genetic characterization of the peptidases of Polistes versicolor (Hymenoptera: Vespidae) [PDF]

open access: yesBrazilian Journal of Biology, 2003
Starch gel electrophoresis with L-leucyl-beta-naphthylamide as substrate revealed five aminopeptidases in extracts of Polistes versicolor. These enzymes are presumably products of five structural gene loci.
M. A. Del Lama, K. M. Ferreira
doaj   +1 more source

Fruit ripening-associated leucylaminopeptidase with cysteinylglycine dipeptidase activity from durian suggests its involvement in glutathione recycling

open access: yesBMC Plant Biology, 2021
Background Durian (Durio zibethinus L.) is a highly popular fruit in Thailand and several other Southeast Asian countries. It is abundant in essential nutrients and sulphur-containing compounds such as glutathione (GSH) and γ-glutamylcysteine (γ-EC ...
Pawinee Panpetch, Supaart Sirikantaramas
doaj   +1 more source

Carnosinases, Their Substrates and Diseases

open access: yesMolecules, 2014
Carnosinases are Xaa-His dipeptidases that play diverse functions throughout all kingdoms of life. Human isoforms of carnosinase (CN1 and CN2) under appropriate conditions catalyze the hydrolysis of the dipeptides carnosine (β-alanyl-L-histidine) and ...
Francesco Bellia   +2 more
doaj   +1 more source

Dpep2 Emerging as a Modulator of Macrophage Inflammation Confers Protection Against CVB3-Induced Viral Myocarditis

open access: yesFrontiers in Cellular and Infection Microbiology, 2019
Overwhelming cardiac inflammation has been reported to be the pathogenic mechanism of Coxsackievirus B3 (CVB3)-induced viral myocarditis (VMC), while the detailed molecular mechanisms remain unknown.
Xiaoli Yang, Yan Yue, Sidong Xiong
doaj   +1 more source

Identification of Urinary Dipeptidase as the Released Form of Renal Dipeptidase

open access: yesKidney and Blood Pressure Research, 1997
Amphipathic and hydrophilic forms of human renal dipeptidase and urinary dipeptidase were purified by affinity chromatography using cilastatin, a dipeptidase inhibitor, as the ligand. The sequence analyses of the first ten amino acids of renal and urinary dipeptidases were shown to be identical, and they are Asp-Phe-Phe-Arg-Asp-Glu-Ala-Glu-Arg-Ile ...
J S, We   +4 more
openaire   +2 more sources

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