Results 141 to 150 of about 83,323 (258)
Advanced Synthesis &Catalysis, Volume 368, Issue 6, 17 March 2026.Selective late‐stage modification of N‐terminal phenylalanine short peptides is achived by visible‐light initiated reaction with N‐iodoimides in a debenzylation–amination process. This metal‐free method permits the incorporation of N‐containing heterocycles into the α‐position of the peptide backbone.
Guillermo Morales‐Ortega +4 more
wiley +1 more source
Self‐Immolative Systems in Diagnostic and Therapeutic Applications
ChemMedChem, Volume 21, Issue 5, 13 March 2026.Self‐Immolative Systems enable the precise, residue‐free release of active molecules, drugs, probes, or sensors, via cyclization or elimination, triggered by specific stimuli. Their versatility drives advances in drug delivery, diagnostics, nanotechnology, materials chemistry, and biosensing, offering chemists control over molecular activation and ...
Windbedema Prisca Ouédraogo +2 more
wiley +1 more source
Catalytic Amyloids: Turning Fibrils Into Biocatalysts
Chemistry – A European Journal, Volume 32, Issue 10, 9 March 2026.Amyloids, traditionally associated with diseases, have emerged as versatile catalytic scaffolds. From natural amyloid sequences to bioinspired and de novo designs, we highlight strategies to construct catalytic active sites and anchor enzymes onto fibrils, creating versatile nanomaterials with tunable activities. ABSTRACT Amyloids have been regarded as
Alessandra Esposito +3 more
wiley +1 more source
Synthetic Studies Towards Darobactin A
Chemistry – A European Journal, Volume 32, Issue 10, 9 March 2026.The urgent need for new antibiotics led us to develop a new methodology for the synthesis of the natural product darobactin A selectively targeting gram‐negative bacteria. This study provides new insights into the synthesis of strained indole‐containing macrocycles.
Till Steiner +4 more
wiley +1 more source
Chiral Glass Formation by Dipeptide Salts. [PDF]
BiomacromoleculesCastelletto V, Hamley IW.
europepmc +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, Volume 600, Issue 5, Page 631-643, March 2026.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Accelerating Replica Exchange Molecular Dynamics: A Comparison of Hydrogen Mass Repartitioning and Light Water Models. [PDF]
J Chem Theory ComputBowers SR +3 more
europepmc +1 more source
Smart Wearable Ozone Therapy System for Managing Multidrug‐Resistant Wound Infections
Advanced Therapeutics, Volume 9, Issue 3, March 2026.A smart wearable ozone therapy system enables precise localized ozone delivery directly to the wound bed through integrated ozone generation, real‐time sensing, and controlled air circulation. Controlled ozone exposure disrupts bacterial membranes, enhances antibiotic accessibility, and supports a clinically translatable strategy for managing multidrug‐
Akshay Krishnakumar +10 more
wiley +1 more source