Results 31 to 40 of about 83,323 (258)

Transcriptome sequencing of hematopoietic stem cells and chronic myelgenous leukemia stem cells

Genomics Data, 2016
Dipeptide species are accumulated in the chronic myelogenous leukemia (CML) stem cells [1]. To investigate the molecular mechanisms of the accumulation of dipeptide species in CML stem cells, we performed transcriptome sequencing of long-term stem cells,
Junil Kim, Seong-Jin Kim, Kazuhito Naka
doaj   +1 more source

Quantum mechanical calculation of the effects of stiff and rigid constraints in the conformational equilibrium of the Alanine dipeptide [PDF]

, 2006
If constraints are imposed on a macromolecule, two inequivalent classical models may be used: the stiff and the rigid one. This work studies the effects of such constraints on the Conformational Equilibrium Distribution (CED) of the model dipeptide HCO-L-
Abagyan, Allen, Almarza, Alonso, Alonso, Andersen, Andricioaei, Arnold, Baker, Barth, Beachy, Berendsen, Berendsen, Berman, Bordner, Born, Brooks, Chakrabarti, Chandler, Chen, Chun, Ciccotti, Cornell, Creighton, Császár, Daykov, Demchuk, Den Otter, Den Otter, Dill, Dinner, Dobson, Dobson, Echenique, Echenique, Elstner, Fixman, Fixman, Frenkel, Gottlieb, Gunasekaran, Gō, Gō, Halgren, Halgren, Halgren, Halgren, Halgren, Halls, He, Helfand, Hess, Hnizdo, Jorgensen, Jorgensen, Karplus, Knapp, Lesk, Levine, Levinthal, Láng, MacKerell, MacKerell, Mardia, Mazars, Mazars, Morse, Pasquali, Patriciu, Pear, Pearlman, Perchak, Perczel, Pertsin, Rallison, Ramachandran, Reich, Reich, Ryckaert, Schlick, Schlitter, Schmidt, Schofield, Schäfer, Scott, Van Gunsteren, Van Gunsteren, Van Kampen, Vargas, Viskolcz, Volkenstein, Wilson, Yu, Zhou, Álvarez-Estrada, Álvarez-Estrada   +95 more
core   +3 more sources

On the Mechanical Properties of N-Functionalised Dipeptide Gels

Molecules, 2019
The properties of a hydrogel are controlled by the underlying network that immobilizes the solvent. For gels formed by the self-assembly of a small molecule, it is common to show the primary fibres that entangle to form the network by microscopy, but it ...
Ana M. Fuentes-Caparrós, Kate McAulay, Sarah E. Rogers, Robert M. Dalgliesh, Dave J. Adams   +4 more
doaj   +1 more source

Enalapril: Synthesis and properties [PDF]

Hemijska Industrija, 2004
Enalapril was originally synthesized by Merck Sharp and Dohme and is an angiotensin converting enzyme inhibitor. Thus, enalapril is used in the treatment of mild to severe hypertension. Enalapril is chemically (S)-1-[N-[1-(et-hoxycarbonyl)-3-phenylpropyl]
Mijin Dušan Ž., Stanković Milena, Petrović Slobodan D.   +2 more
doaj   +1 more source

Production and Immunogenicity of a Tag-Free Recombinant Chimera Based on PfMSP-1 and PfMSP-3 Using Alhydrogel and Dipeptide-Based Hydrogels

Vaccines, 2021
A fusion chimeric vaccine comprising multiple protective domains of different blood-stage Plasmodium falciparum antigens is perhaps necessary for widening the protective immune responses and reducing the morbidity caused by the disease.
Gaurav Anand, Saikat Biswas, Nitin Yadav, Paushali Mukherjee, Virander Singh Chauhan   +4 more
doaj   +1 more source

Delineation of the Pasteurellaceae-specific GbpA-family of glutathione-binding proteins [PDF]

, 2011
Background: The Gram-negative bacterium Haemophilus influenzae is a glutathione auxotroph and acquires the redox-active tripeptide by import. The dedicated glutathione transporter belongs to the ATP-binding cassette (ABC)-transporter superfamily and ...
Vergauwen, Bjorn, Van der Meeren, Ruben, Dansercoer, Ann, Savvides, Savvas   +3 more
core   +1 more source

Allosteric Activation of the Par-6 PDZ Via a Partial Unfolding Transition [PDF]

, 2013
Proteins exist in a delicate balance between the native and unfolded states, where thermodynamic stability may be sacrificed to attain the flexibility required for efficient catalysis, binding, or allosteric control.
Kovrigin, Evgeni L., Peterson, Francis C., Volkman, Brian F., Whitney, Dustin S.   +3 more
core   +2 more sources

Maximum Flux Transition Paths of Conformational Change

, 2010
Given two metastable states A and B of a biomolecular system, the problem is to calculate the likely paths of the transition from A to B. Such a calculation is more informative and more manageable if done for a reduced set of collective variables chosen ...
Berkowitz M., Bolhuis P. G., Bolhuis P. G., Brooks B. R., Brooks B. R., Chu J., Crehuet R., E W., E W., E, W., Elber R., Essmann U., Frenkel D., Gan W., Huang H., Huo S., Jiménez A., Jorgensen W. L., Jónsson H., Lei M., Ma A., MacKerell A. D., Mackerell, Jr A. D., Maragliano L., Metzner P., Onsager L., Ozkirimli E., Ozkirimli E., Pan A. C., Park S., Phillips J. C., Ren W., Ryckaert J.-P., Schlitter J., Singhal N., Vanden-Eijnden E., Vanden-Eijnden E., Vanden-Eijnden E., Vanden-Eijnden E., Yang S., Zhang J.   +40 more
core   +1 more source

CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity. [PDF]

, 2018
Hexanucleotide-repeat expansions in the C9ORF72 gene are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD).
A Berson, A Jovičić, AA Dominguez, Aaron D. Gitler, AC Elden, AD Gitler, AD Gitler, AD Gitler, AE Renton, AM Jablonski, Amy Li, Ana Jovičić, AS Ng, BD Freibaum, C Sidrauski, C Sidrauski, C. Kimberly Tsui, D Ron, David W. Morgens, DW Morgens, DW Morgens, E Yeger-Lotem, EM Lynes, EY Son, FB Gao, Gregor Bieri, H Koike-Yusa, HJ Kim, HJ Kim, I Kwon, IR Mackenzie, IR Mackenzie, J Couthouis, J Joung, James Ousey, JC Christianson, JG Wideman, JP Taylor, Julien Couthouis, Justin K. Ichida, K Kanekura, K Mori, K Zhang, KH Lee, KM Green, KY Shi, L Ellgaard, L Huang, LA Becker, LA Gilbert, LA Gilbert, M Armakola, M DeJesus-Hernandez, M Neumann, M Prudencio, MA Horlbeck, Marc Tessier-Lavigne, MC Jonikas, MH Schludi, MI Love, Michael C. Bassik, Michael S. Haney, NF Liachko, Nicholas J. Kramer, Nicholas T. Hertz, O Shalem, OM Peters, PE Ash, Q Zhou, R Dafinca, R Lopez-Gonzalez, R Seijffers, RJ Platt, RM Deans, Rosanna Ma, S Boeynaems, S Boeynaems, S Ju, S Konermann, S Mizielinska, S Treusch, SC Ling, SJ Zhang, T Wang, T Westergard, T Zu, TF Gendron, W Cheng, X Wen, Y Lin, Y Zhou, Yingxiao Shi, YJ Zhang, YS Davidson, Z Shevtsova, Z Sun   +95 more
core   +1 more source

Interaction of Phenanthroline-Containing Copper Complexes with Model Phospholipid Membranes

Inorganics
Medicinal Inorganic Chemistry has provided oncology with metallodrugs for cancer treatment, including several promising candidate drugs. In particular, copper(II) coordination compounds with phenanthroline stand out as potential anticancer agents.
Priscilla Freddi, Natalia Alvarez, Gianella Facchin, Antonio J. Costa-Filho   +3 more
doaj   +1 more source